AD 5467

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 591053

CAS#: 138333-32-1

Description: AD-5467 is a bioactive chemical.

Chemical Structure

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AD 5467
CAS# 138333-32-1
Instruction

Theoretical Analysis

MedKoo Cat#: 591053
Name: AD 5467
CAS#: 138333-32-1
Chemical Formula: C16H21NO3S
Exact Mass: 307.12
Molecular Weight: 307.410
Elemental Analysis: C, 62.51; H, 6.89; N, 4.56; O, 15.61; S, 10.43

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: AD 5467; AD5467; AD-5467

IUPAC/Chemical Name: 2H-1,4-Benzoxazine-4-acetic acid, 3,4-dihydro-2,8-diisopropyl-3-thioxo-

InChi Key: CLDJCRWXLDLJLO-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H21NO3S/c1-9(2)11-6-5-7-12-15(11)20-14(10(3)4)16(21)17(12)8-13(18)19/h5-7,9-10,14H,8H2,1-4H3,(H,18,19)

SMILES Code: O=C(O)CN1C(C(C(C)C)OC2=C(C(C)C)C=CC=C12)=S

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 307.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Win T, Asano G, Shimizu Y. The efficacy of aldose reductase inhibitor, antioxidant butylated hydroxytoluene and cysteine protease inhibitor E64 on hyperglycemia-induced metabolic changes in the organ-cultured bovine lens. Nihon Ika Daigaku Zasshi. 1994 Jun;61(3):180-9. PubMed PMID: 8045992.

2: Chanalet L, Lapalus P. Drugs designed to maintain the transparence of the ocular lens. Fundam Clin Pharmacol. 1994;8(4):322-41. Review. PubMed PMID: 7851838.

3: Ohtori A, Yamamoto Y, Tojo KJ. Penetration and binding of aldose-reductase inhibitors in the lens. Invest Ophthalmol Vis Sci. 1991 Jan;32(1):189-93. PubMed PMID: 1898917.

4: Tawada H, Sugiyama Y, Ikeda H, Yamamoto Y, Meguro K. Studies on antidiabetic agents. IX. A new aldose reductase inhibitor, AD-5467, and related 1,4-benzoxazine and 1,4-benzothiazine derivatives: synthesis and biological activity. Chem Pharm Bull (Tokyo). 1990 May;38(5):1238-45. PubMed PMID: 2118427.

5: Yamamoto Y, Ohtori A. In vitro study of aldose reductase inhibitor concentrations in the lens and inhibitory effect on sugar alcohol accumulation. Curr Eye Res. 1990 May;9(5):421-8. PubMed PMID: 2116955.