Hgg 12

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 584421

CAS#: 83972-73-0

Description: Hgg 12 is used therapeutically in organophosphate poisoning.

Chemical Structure

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Hgg 12
CAS# 83972-73-0
Instruction

Theoretical Analysis

MedKoo Cat#: 584421
Name: Hgg 12
CAS#: 83972-73-0
Chemical Formula: C20H19Cl2N3O3
Exact Mass: 419.08
Molecular Weight: 420.290
Elemental Analysis: C, 57.16; H, 4.56; Cl, 16.87; N, 10.00; O, 11.42

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Hgg 12; Hgg12; Hgg-12

IUPAC/Chemical Name: Pyridinium, 1-(((3-benzoylpyridinio)methoxy)methyl)-2-((hydroxyimino)methyl)-, dichloride

InChi Key: WEOUPFRRXAHWCD-UHFFFAOYSA-M

InChi Code: InChI=1S/C20H18N3O3.2ClH/c24-20(17-7-2-1-3-8-17)18-9-6-11-22(14-18)15-26-16-23-12-5-4-10-19(23)13-21-25;;/h1-14H,15-16H2;2*1H/q+1;;/p-1

SMILES Code: O/N=C/C1=CC=CC=[N+]1COC[N+]2=CC=CC(C(C3=CC=CC=C3)=O)=C2.[Cl-].[Cl-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 420.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Hauser W, Weger N. Therapeutic effects of the bis-pyridinium salts HGG-12, HGG-42, and atropine, benactyzine in organophosphate poisoning of dogs. Arch Toxicol Suppl. 1979;(2):393-6. PubMed PMID: 288351.

2: van Helden HP, van der Wiel HJ, Zijlstra JJ, Melchers BP, Busker RW. Comparison of the therapeutic effects and pharmacokinetics of HI-6, HLö-7, HGG-12, HGG-42 and obidoxime following non-reactivatable acetylcholinesterase inhibition in rats. Arch Toxicol. 1994;68(4):224-30. PubMed PMID: 8067894.

3: Cetković S, Cvetković M, Jandrić D, Cosić M, Bosković B. Effect of PAM-2 Cl, HI-6, and HGG-12 in poisoning by tabun and its thiocholine-like analog in the rat. Fundam Appl Toxicol. 1984 Apr;4(2 Pt 2):S116-23. PubMed PMID: 6547103.

4: Bosković B, Kovacević V, Jovanović D. PAM-2 Cl, HI-6, and HGG-12 in soman and tabun poisoning. Fundam Appl Toxicol. 1984 Apr;4(2 Pt 2):S106-15. PubMed PMID: 6724203.

5: Klimmek R, Eyer P. Pharmacokinetics and toxicity of the oxime HGG 12 in dogs. Arch Toxicol. 1985 Sep;57(4):237-42. PubMed PMID: 4091648.

6: Reithmann C, Berger HJ, Hilf G, Werdan K. The oxime HGG-12 as a muscarinic acetylcholine receptor antagonist without intrinsic activity in cardiac membranes. Arch Toxicol. 1991;65(6):518-23. PubMed PMID: 1929874.

7: Pantelić D. [Comparative reactivation efficacy of the oximes HI-6 and HGG-12 in the central nervous system and blood of rats poisoned with nerve gases used in warfare]. God Vojnomed Akad. 1986;28:35-40. Croatian. PubMed PMID: 3482058.

8: Kloog Y, Galron R, Balderman D, Sokolovsky M. Reversible and irreversible inhibition of rat brain muscarinic receptors is related to different substitutions on bisquaternary pyridinium oximes. Arch Toxicol. 1985 Oct;58(1):37-9. PubMed PMID: 3907590.

9: Eyer P, Hell W. The metabolism of 3-benzoylpyridine. Xenobiotica. 1983 Nov;13(11):649-59. PubMed PMID: 6673376.

10: van Helden HP, van der Wiel HJ, Wolthuis OL. Therapy of organophosphate poisoning: the marmoset as a model for man. Br J Pharmacol. 1983 Mar;78(3):579-89. PubMed PMID: 6301602; PubMed Central PMCID: PMC2044728.

11: Clement JG. Efficacy of mono- and bis-pyridinium oximes versus soman, sarin and tabun poisoning in mice. Fundam Appl Toxicol. 1983 Nov-Dec;3(6):533-5. PubMed PMID: 6662294.

12: van Helden HP, de Lange J, Busker RW, Melchers BP. Therapy of organophosphate poisoning in the rat by direct effects of oximes unrelated to ChE reactivation. Arch Toxicol. 1991;65(7):586-93. PubMed PMID: 1664202.

13: Schlagmann C, Ulbrich H, Remien J. Bispyridinium (oxime) compounds antagonize the "ganglion blocking" effect of pyridostigmine in isolated superior cervical ganglia of the rat. Arch Toxicol. 1990;64(6):482-9. PubMed PMID: 1980409.

14: Jovanović D. The effect of bis-pyridinium oximes on neuromuscular blockade induced by highly toxic organophosphates in rat. Arch Int Pharmacodyn Ther. 1983 Apr;262(2):231-41. PubMed PMID: 6307195.

15: Lundy PM, Tremblay KP. Ganglion blocking properties of some bispyridinium soman antagonists. Eur J Pharmacol. 1979 Nov 23;60(1):47-53. PubMed PMID: 42547.

16: Kuhnen-Clausen D, Hagedorn I, Gross G, Bayer H, Hucho F. Interactions of bisquaternary pyridine salts (H-oximes) with cholinergic receptors. Arch Toxicol. 1983 Nov;54(3):171-9. PubMed PMID: 6661028.

17: Eyer P, Kawan A, Ladstetter B. Formation of cyanide after i.v. administration of the oxime HI 6 to dogs. Arch Toxicol. 1987;61(1):63-9. PubMed PMID: 3439876.

18: Endres W, Spuler A, ten Bruggencate G. Acetylcholinesterase reactivators antagonize epileptiform bursting induced by paraoxon in guinea pig hippocampal slices. J Pharmacol Exp Ther. 1989 Dec;251(3):1181-6. PubMed PMID: 2600810.

19: Hauser W, Kirsch D, Weger N. Therapeutic effects of new oximes, benactyzine and atropine in Soman poisoning: Part II. effect of HGG12, HGG42, and obidoxime in poisoning with various anticholinesterase agents in Beagle dogs. Fundam Appl Toxicol. 1981 Mar-Apr;1(2):164-8. PubMed PMID: 6764202.

20: Kloog Y, Galron R, Sokolovsky M. Bisquaternary pyridinium oximes as presynaptic agonists and postsynaptic antagonists of muscarinic receptors. J Neurochem. 1986 Mar;46(3):767-72. PubMed PMID: 3950607.