Vif-A3G Inhibitor N.41

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 562270

CAS#: 357441-99-7

Description: Vif-A3G Inhibitor N.41 is a HIV-1 inhibitor-targeting drug that causes Vif-dependent degradation of human APOBEC3G, thereby inhibiting the Vif-A3G interaction.


Price and Availability

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Vif-A3G Inhibitor N.41 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 562270
Name: Vif-A3G Inhibitor N.41
CAS#: 357441-99-7
Chemical Formula: C15H14N2O2
Exact Mass: 254.1055
Molecular Weight: 254.28
Elemental Analysis: C, 70.85; H, 5.55; N, 11.02; O, 12.58


Synonym: Vif-A3G Inhibitor N.41; VifA3G Inhibitor N.41; Vif-A3G Inhibitor-N.41;

IUPAC/Chemical Name: (2Z)-3-[(4-Hydroxyphenyl)amino]-1-(3-pyridinyl)-2-buten-1-one

InChi Key: YJVDMNPGQGXXGJ-LUAWRHEFSA-N

InChi Code: InChI=1S/C15H14N2O2/c1-11(17-13-4-6-14(18)7-5-13)9-15(19)12-3-2-8-16-10-12/h2-10,17-18H,1H3/b11-9-

SMILES Code: C/C(NC1=CC=C(O)C=C1)=C/C(C2=CC=CN=C2)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Pery E, Sheehy A, Nebane NM, Brazier AJ, Misra V, Rajendran KS, Buhrlage SJ, Mankowski MK, Rasmussen L, White EL, Ptak RG, Gabuzda D. Identification of a novel HIV-1 inhibitor targeting Vif-dependent degradation of human APOBEC3G protein. J Biol Chem. 2015 Apr 17;290(16):10504-17. doi: 10.1074/jbc.M114.626903. Epub 2015 Feb 27. PubMed PMID: 25724652; PubMed Central PMCID: PMC4400358.