Rivanicline

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 562249

CAS#: 15585-43-0

Description: Rivanicline is a partial agonist of neural nicotinic acetylcholine receptors. It acts by selectively binding primarily to the α4β2 subtype.

Chemical Structure

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Rivanicline
CAS# 15585-43-0
Instruction

Theoretical Analysis

MedKoo Cat#: 562249
Name: Rivanicline
CAS#: 15585-43-0
Chemical Formula: C10H14N2
Exact Mass: 162.12
Molecular Weight: 162.230
Elemental Analysis: C, 74.03; H, 8.70; N, 17.27

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Rivanicline; Metanicotine; RJR-2403; RJR 2403; RJR2403; Metanicotine; Rivanicline oxalate;

IUPAC/Chemical Name: (E)-N-Methyl-4-pyridin-3-ylbut-3-en-1-amine

InChi Key: JUOSGGQXEBBCJB-GORDUTHDSA-N

InChi Code: InChI=1S/C10H14N2/c1-11-7-3-2-5-10-6-4-8-12-9-10/h2,4-6,8-9,11H,3,7H2,1H3/b5-2+

SMILES Code: CNCC/C=C/C1=CC=CN=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 162.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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5: Fedotova YO. [Co-administration of RJR-2403 with low dose of 17beta-estradiol on spatial learning in ovariectomized rats]. Patol Fiziol Eksp Ter. 2013 Jul-Sep;(3):37-41. Russian. PubMed PMID: 24340617.

6: Fedotova IuO, Sapronov NS. [Chronic administration of RJR-2403 in combination with low-dose of 17beta-estradiol corrects passive avoidance learning in ovariectomized rats]. Eksp Klin Farmakol. 2013;76(5):3-6. Russian. PubMed PMID: 23901460.

7: Fedotova IuO. [Influence of agonist and antagonist Nalpha7-cholinoreceptors on active avoidance learning and gonadal hormones levels in ovariectomized female rats]. Ross Fiziol Zh Im I M Sechenova. 2013 Apr;99(4):484-90. Russian. PubMed PMID: 23862388.

8: Garduño J, Galindo-Charles L, Jiménez-Rodríguez J, Galarraga E, Tapia D, Mihailescu S, Hernandez-Lopez S. Presynaptic α4β2 nicotinic acetylcholine receptors increase glutamate release and serotonin neuron excitability in the dorsal raphe nucleus. J Neurosci. 2012 Oct 24;32(43):15148-57. doi: 10.1523/JNEUROSCI.0941-12.2012. PubMed PMID: 23100436.

9: Hijioka M, Matsushita H, Ishibashi H, Hisatsune A, Isohama Y, Katsuki H. α7 Nicotinic acetylcholine receptor agonist attenuates neuropathological changes associated with intracerebral hemorrhage in mice. Neuroscience. 2012 Oct 11;222:10-9. doi: 10.1016/j.neuroscience.2012.07.024. Epub 2012 Jul 20. PubMed PMID: 22820264.

10: Taslim N, Soderstrom K, Dar MS. Role of mouse cerebellar nicotinic acetylcholine receptor (nAChR) α(4)β(2)- and α(7) subtypes in the behavioral cross-tolerance between nicotine and ethanol-induced ataxia. Behav Brain Res. 2011 Mar 1;217(2):282-92. doi: 10.1016/j.bbr.2010.10.026. Epub 2010 Oct 23. PubMed PMID: 20974182.

11: MacLeod JE, Vucovich MM, Bucci DJ. Differential effects of nicotinic acetylcholine receptor stimulation on negative occasion setting. Behav Neurosci. 2010 Oct;124(5):656-61. doi: 10.1037/a0020904. PubMed PMID: 20939665; PubMed Central PMCID: PMC2955320.

12: Rushforth SL, Allison C, Wonnacott S, Shoaib M. Subtype-selective nicotinic agonists enhance olfactory working memory in normal rats: a novel use of the odour span task. Neurosci Lett. 2010 Mar 3;471(2):114-8. doi: 10.1016/j.neulet.2010.01.022. Epub 2010 Jan 18. PubMed PMID: 20083163.

13: Yang K, Hu J, Lucero L, Liu Q, Zheng C, Zhen X, Jin G, Lukas RJ, Wu J. Distinctive nicotinic acetylcholine receptor functional phenotypes of rat ventral tegmental area dopaminergic neurons. J Physiol. 2009 Jan 15;587(2):345-61. doi: 10.1113/jphysiol.2008.162743. Epub 2008 Dec 1. PubMed PMID: 19047205; PubMed Central PMCID: PMC2670049.

14: Taslim N, Al-Rejaie S, Saeed Dar M. Attenuation of ethanol-induced ataxia by alpha(4)beta(2) nicotinic acetylcholine receptor subtype in mouse cerebellum: a functional interaction. Neuroscience. 2008 Nov 11;157(1):204-13. doi: 10.1016/j.neuroscience.2008.08.046. Epub 2008 Aug 27. PubMed PMID: 18812210.

15: Rowley TJ, Payappilly J, Lu J, Flood P. The antinociceptive response to nicotinic agonists in a mouse model of postoperative pain. Anesth Analg. 2008 Sep;107(3):1052-7. doi: 10.1213/ane.0b013e318165e0c0. PubMed PMID: 18713928.

16: Sapronov NS, Fedotova YO, Kuznetsova NN. Antiamnestic effect of alpha7-nicotinic receptor agonist RJR-2403 in middle-aged ovariectomized rats with Alzheimer type dementia. Bull Exp Biol Med. 2006 Dec;142(6):700-2. English, Russian. PubMed PMID: 17603674.

17: Smith AD, Dar MS. Behavioral cross-tolerance between repeated intracerebellar nicotine and acute Delta(9)-tetrahydrocannabinol-induced cerebellar ataxia: role of cerebellar nitric oxide. J Pharmacol Exp Ther. 2007 Jul;322(1):243-53. Epub 2007 Apr 6. PubMed PMID: 17416741.

18: Smith AD, Dar MS. Involvement of the alpha4beta2 nicotinic receptor subtype in nicotine-induced attenuation of delta9-THC cerebellar ataxia: role of cerebellar nitric oxide. Pharmacol Biochem Behav. 2007 Jan;86(1):103-12. Epub 2006 Dec 28. PubMed PMID: 17275078.

19: Abdin MJ, Morioka N, Morita K, Kitayama T, Kitayama S, Nakashima T, Dohi T. Analgesic action of nicotine on tibial nerve transection (TNT)-induced mechanical allodynia through enhancement of the glycinergic inhibitory system in spinal cord. Life Sci. 2006 Dec 3;80(1):9-16. Epub 2006 Aug 17. PubMed PMID: 16950410.

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