Physapubenolide

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 581067

CAS#: 100217-92-3

Description: Physapubenolide is natural cytotoxic withanolide antitumor agent, inducing apoptosis by decreasing mitochondrial membrane potential and elevating the Bax/Bcl-2 protein expression ratio. Downregulation of TIGAR sensitizes the antitumor effect of physapubenolide through increasing intracellular ROS levels to trigger apoptosis and autophagosome formation in human breast carcinoma cells. Metabonomics applied in exploring the antitumour mechanism of physapubenolide on hepatocellular carcinoma cells by targeting glycolysis through the Akt-p53 pathway.

Chemical Structure

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Physapubenolide
CAS# 100217-92-3
Instruction

Theoretical Analysis

MedKoo Cat#: 581067
Name: Physapubenolide
CAS#: 100217-92-3
Chemical Formula: C30H40O8
Exact Mass: 528.27
Molecular Weight: 528.640
Elemental Analysis: C, 68.16; H, 7.63; O, 24.21

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Physapubenolide; NSC368674; NSC 368674; NSC-368674

IUPAC/Chemical Name: 15-[1-(4,5-dimethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)ethyl]-6,12-dihydroxy-2,16-dimethyl-3-oxo-8-oxapentacyclo[9.7.0.0;{2,7}.0;{7,9}.0;{12,16}]octadec-4-en-13-yl acetate

InChi Key: OPYWYTLAPWWTKW-UHFFFAOYSA-N

InChi Code: InChI=1S/C30H40O8/c1-14-11-21(37-26(34)15(14)2)16(3)19-12-24(36-17(4)31)29(35)20-13-25-30(38-25)23(33)8-7-22(32)28(30,6)18(20)9-10-27(19,29)5/h7-8,16,18-21,23-25,33,35H,9-13H2,1-6H3

SMILES Code: CC(OC(CC(C(C1CC(C)=C(C)C(O1)=O)C)C2(C)CC3)C2(O)C(C3C45C)CC6OC65C(O)C=CC4=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 528.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Ma T, Zhang Y, Zhang C, Luo JG, Kong LY. Downregulation of TIGAR sensitizes the antitumor effect of physapubenolide through increasing intracellular ROS levels to trigger apoptosis and autophagosome formation in human breast carcinoma cells. Biochem Pharmacol. 2017 Nov 1;143:90-106. doi: 10.1016/j.bcp.2017.07.018. Epub 2017 Aug 1. PubMed PMID: 28774732.

2: Ma T, Fan BY, Zhang C, Zhao HJ, Han C, Gao CY, Luo JG, Kong LY. Metabonomics applied in exploring the antitumour mechanism of physapubenolide on hepatocellular carcinoma cells by targeting glycolysis through the Akt-p53 pathway. Sci Rep. 2016 Jul 15;6:29926. doi: 10.1038/srep29926. PubMed PMID: 27416811; PubMed Central PMCID: PMC4945937.