PU139
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 527673

CAS#: 158093-65-3

Description: PU139 is a novel histone acetyltransferase (HAT) inhibitor.

Chemical Structure

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PU139
CAS# 158093-65-3
Instruction

Theoretical Analysis

MedKoo Cat#: 527673
Name: PU139
CAS#: 158093-65-3
Chemical Formula: C12H7FN2OS
Exact Mass: 246.03
Molecular Weight: 246.259
Elemental Analysis: C, 58.53; H, 2.87; F, 7.71; N, 11.38; O, 6.50; S, 13.02

Price and Availability

Size Price Availability Quantity
5mg USD 450 2 Weeks
10mg USD 750 2 Weeks
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Synonym: PU139; PU-139; PU 139

IUPAC/Chemical Name: 2-(4-Fluorophenyl)isothiazolo[5,4-b]pyridin-3(2H)-one

InChi Key: QMCIVCACYJRAAY-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H7FN2OS/c13-8-3-5-9(6-4-8)15-12(16)10-2-1-7-14-11(10)17-15/h1-7H

SMILES Code: O=C1N(C2=CC=C(F)C=C2)SC3=NC=CC=C31

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 246.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Gajer JM, Furdas SD, Gründer A, Gothwal M, Heinicke U, Keller K, Colland F, Fulda S, Pahl HL, Fichtner I, Sippl W, Jung M. Histone acetyltransferase inhibitors block neuroblastoma cell growth in vivo. Oncogenesis. 2015 Feb 9;4:e137. doi: 10.1038/oncsis.2014.51. PubMed PMID: 25664930; PubMed Central PMCID: PMC4338425.

2: Carneiro VC, de Abreu da Silva IC, Torres EJ, Caby S, Lancelot J, Vanderstraete M, Furdas SD, Jung M, Pierce RJ, Fantappié MR. Epigenetic changes modulate schistosome egg formation and are a novel target for reducing transmission of schistosomiasis. PLoS Pathog. 2014 May 8;10(5):e1004116. doi: 10.1371/journal.ppat.1004116. eCollection 2014 May. PubMed PMID: 24809504; PubMed Central PMCID: PMC4014452.