Ioxitalamic Acid

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561634

CAS#: 28179-44-4

Description: Ioxitalamic Acid, also known as Telebrix or Vasobrix, is a medical contrast medium. It enhances the contrast of structures or fluids within the body in medical imaging.

Chemical Structure

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Ioxitalamic Acid
CAS# 28179-44-4
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 561634
Name: Ioxitalamic Acid
CAS#: 28179-44-4
Chemical Formula: C12H11I3N2O5
Exact Mass: 643.78
Molecular Weight: 643.942
Elemental Analysis: C, 22.38; H, 1.72; I, 59.12; N, 4.35; O, 12.42

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Ioxitalamic Acid; Telebrix; Vasobrix;

IUPAC/Chemical Name: 3-Acetamido-5-(2-hydroxyethylcarbamoyl)-2,4,6-triiodobenzoic acid

InChi Key: OLAOYPRJVHUHCF-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H11I3N2O5/c1-4(19)17-10-8(14)5(11(20)16-2-3-18)7(13)6(9(10)15)12(21)22/h18H,2-3H2,1H3,(H,16,20)(H,17,19)(H,21,22)

SMILES Code: O=C(O)C1=C(I)C(C(NCCO)=O)=C(I)C(NC(C)=O)=C1I

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Product Data
Instruction:
View handling instruction
Biological target: Ioxitalamic Acid, also known as Telebrix or Vasobrix, is a medical contrast medium.
In vitro activity: Following treatment for 48 h, the highly toxic radiocontrast agent, ioxitalamate, exerted cytotoxic effects on the HK-2 cells in a concentration-dependent manner, as shown by MTT assay. The half maximal inhibitory concentration (IC50) was found to be approximately 30 mg/ml. Flow cytometry also revealed a marked increase in the number of apoptotic cells following exposure to ioxitalamate. In addition, the number of necrotic, but not necroptotic cells was increased. Reference: Int J Mol Med. 2016 Jan;37(1):83-91. https://pubmed.ncbi.nlm.nih.gov/26573558/
In vivo activity: The administration of TBX (ioxitalamic acid) induced a significant (p < 0.001) increase in serum urea and creatinine levels of treated rats with respect to the control. Reference: Antioxidants (Basel). 2021 Feb 2;10(2):221. https://pubmed.ncbi.nlm.nih.gov/33540787/

Preparing Stock Solutions

The following data is based on the product molecular weight 643.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Huang YT, Chen YY, Lai YH, Cheng CC, Lin TC, Su YS, Liu CH, Lai PC. Resveratrol alleviates the cytotoxicity induced by the radiocontrast agent, ioxitalamate, by reducing the production of reactive oxygen species in HK-2 human renal proximal tubule epithelial cells in vitro. Int J Mol Med. 2016 Jan;37(1):83-91. doi: 10.3892/ijmm.2015.2404. Epub 2015 Nov 9. PMID: 26573558; PMCID: PMC4687441. 2. El-Garawani I, Hassab El-Nabi S, El Kattan A, Sallam A, Elballat S, Abou-Ghanima S, El Azab IH, R El-Seedi H, A M Khalifa S, El-Shamy S. The Ameliorative Role of Acacia senegal Gum against the Oxidative Stress and Genotoxicity Induced by the Radiographic Contrast Medium (Ioxitalamate) in Albino Rats. Antioxidants (Basel). 2021 Feb 2;10(2):221. doi: 10.3390/antiox10020221. PMID: 33540787; PMCID: PMC7912984.
In vitro protocol: 1. Huang YT, Chen YY, Lai YH, Cheng CC, Lin TC, Su YS, Liu CH, Lai PC. Resveratrol alleviates the cytotoxicity induced by the radiocontrast agent, ioxitalamate, by reducing the production of reactive oxygen species in HK-2 human renal proximal tubule epithelial cells in vitro. Int J Mol Med. 2016 Jan;37(1):83-91. doi: 10.3892/ijmm.2015.2404. Epub 2015 Nov 9. PMID: 26573558; PMCID: PMC4687441.
In vivo protocol: 1. El-Garawani I, Hassab El-Nabi S, El Kattan A, Sallam A, Elballat S, Abou-Ghanima S, El Azab IH, R El-Seedi H, A M Khalifa S, El-Shamy S. The Ameliorative Role of Acacia senegal Gum against the Oxidative Stress and Genotoxicity Induced by the Radiographic Contrast Medium (Ioxitalamate) in Albino Rats. Antioxidants (Basel). 2021 Feb 2;10(2):221. doi: 10.3390/antiox10020221. PMID: 33540787; PMCID: PMC7912984.

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1: Roux FA, Deschamps JY. Inadvertent intrathecal administration of ionic contrast medium to a dog. Vet Radiol Ultrasound. 2007 Sep-Oct;48(5):414-7. Review. PubMed PMID: 17899973.

2: van der Leede H, Jorens PG, Parizel P, Cras P. Inadvertent intrathecal use of ionic contrast agent. Eur Radiol. 2002 Dec;12 Suppl 3:S86-93. Epub 2002 Jun 4. Review. PubMed PMID: 12522612.

3: Sergeev PV, Sviridov NK, Poliaev IuA, Shimanovskiĭ NL. [Diagnostic effectiveness and safety of currently available X-ray contrast media]. Vestn Rentgenol Radiol. 1999 Nov-Dec;(6):45-9. Review. Russian. PubMed PMID: 10714233.