IPI-3063

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MedKoo CAT#: 206927

CAS#: 1425043-73-7

Description: IPI-3063 is a Selective Phosphoinoside-3-Kinase p110δ Inhibitor. IPI-3063 Potently Suppresses B Cell Survival, Proliferation, and Differentiation. IPI-3063 is a highly potent molecule useful for studying p110δ function in immune cells.

Chemical Structure

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IPI-3063
CAS# 1425043-73-7
Instruction

Theoretical Analysis

MedKoo Cat#: 206927
Name: IPI-3063
CAS#: 1425043-73-7
Chemical Formula: C25H25N7O2
Exact Mass: 455.21
Molecular Weight: 455.522
Elemental Analysis: C, 65.92; H, 5.53; N, 21.52; O, 7.02

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: IPI-3063; IPI 3063; IPI3063.  

Synonym:

IUPAC/Chemical Name: (S)-4-amino-6-((1-(2-isopropyl-8-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-1-oxo-1,2-dihydroisoquinolin-3-yl)ethyl)amino)pyrimidine-5-carbonitrile

InChi Key: OBHAYOJCPNWKBL-HNNXBMFYSA-N

InChi Code: InChI=1S/C25H25N7O2/c1-14(2)32-20(15(3)30-24-19(11-26)23(27)28-13-29-24)10-16-6-5-7-18(22(16)25(32)34)17-8-9-21(33)31(4)12-17/h5-10,12-15H,1-4H3,(H3,27,28,29,30)/t15-/m0/s1

SMILES Code: O=C1N(C)C=C(C2=CC=CC(C=C([C@@H](NC3=C(C#N)C(N)=NC=N3)C)N4C(C)C)=C2C4=O)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: The class I phosphoinoside-3-kinases (PI3Ks) are important enzymes that relay signals from cell surface receptors to downstream mediators driving cellular functions. Elevated PI3K signaling is found in B cell malignancies and lymphocytes of patients with autoimmune disease. The p110δ catalytic isoform of PI3K is a rational target since it is critical for B lymphocyte development, survival, activation, and differentiation. In addition, activating mutations in PIK3CD encoding p110δ cause a human immunodeficiency known as activated PI3K delta syndrome.

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 455.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Chiu H, Mallya S, Nguyen P, Mai A, Jackson LV, Winkler DG, DiNitto JP, Brophy
EE, McGovern K, Kutok JL, Fruman DA. The Selective Phosphoinoside-3-Kinase p110δ
Inhibitor IPI-3063 Potently Suppresses B Cell Survival, Proliferation, and
Differentiation. Front Immunol. 2017 Jun 30;8:747. doi: 10.3389/fimmu.2017.00747.
eCollection 2017. PubMed PMID: 28713374; PubMed Central PMCID: PMC5491903.