DIM

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526197

CAS#: 1968-05-4

Description: DIM is an inducer of CYP3A4 and MDR1 gene expression by activating human PXR.

Chemical Structure

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DIM
CAS# 1968-05-4
Instruction

Theoretical Analysis

MedKoo Cat#: 526197
Name: DIM
CAS#: 1968-05-4
Chemical Formula: C17H14N2
Exact Mass: 246.12
Molecular Weight: 246.313
Elemental Analysis: C, 82.90; H, 5.73; N, 11.37

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: DIM

IUPAC/Chemical Name: 3,3'-Methylenebis-1H-indole

InChi Key: VFTRKSBEFQDZKX-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H14N2/c1-3-7-16-14(5-1)12(10-18-16)9-13-11-19-17-8-4-2-6-15(13)17/h1-8,10-11,18-19H,9H2

SMILES Code: C1(CC2=CNC3=C2C=CC=C3)=CNC4=C1C=CC=C4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 246.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Yang H, Seo SG, Shin SH, Min S, Kang MJ, Yoo R, Kwon JY, Yue S, Kim KH, Cheng JX, Kim JR, Park JS, Kim JH, Park JHY, Lee HJ, Lee KW. 3,3'-Diindolylmethane suppresses high-fat diet-induced obesity through inhibiting adipogenesis of pre-adipocytes by targeting USP2 activity. Mol Nutr Food Res. 2017 Jun 6. doi: 10.1002/mnfr.201700119. [Epub ahead of print] PubMed PMID: 28586165.

2: Zhang X, Sukamporn P, Zhang S, Min KW, Baek SJ. 3,3'-diindolylmethane downregulates cyclin D1 through triggering endoplasmic reticulum stress in colorectal cancer cells. Oncol Rep. 2017 Jun 1. doi: 10.3892/or.2017.5693. [Epub ahead of print] PubMed PMID: 28586058.

3: Diaz-Arevalo D, Kalkum M. CD4(+) T Cells Mediate Aspergillosis Vaccine Protection. Methods Mol Biol. 2017;1625:281-293. doi: 10.1007/978-1-4939-7104-6_19. PubMed PMID: 28584997.

4: Palomera-Sanchez Z, Watson GW, Wong CP, Beaver LM, Williams DE, Dashwood RH, Ho E. The phytochemical 3,3'-diindolylmethane decreases expression of AR-controlled DNA damage repair genes through repressive chromatin modifications and is associated with DNA damage in prostate cancer cells. J Nutr Biochem. 2017 May 25;47:113-119. doi: 10.1016/j.jnutbio.2017.05.005. [Epub ahead of print] PubMed PMID: 28582660.

5: Liu K, Xin H, Settar P. Effects of light-emitting diode light v. fluorescent light on growing performance, activity levels and well-being of non-beak-trimmed W-36 pullets. Animal. 2017 Jun 5:1-10. doi: 10.1017/S1751731117001240. [Epub ahead of print] PubMed PMID: 28578737.

6: Quantin C, Collin C, Frérot M, Besson J, Cottenet J, Corneloup M, Soudry-Faure A, Mariet AS, Roussot A; pour le groupe REDSIAM–Troubles mentaux et du comportement. [Study of algorithms to identify schizophrenia in the SNIIRAM database conducted by the REDSIAM network]. Rev Epidemiol Sante Publique. 2017 May 30. pii: S0398-7620(17)30405-4. doi: 10.1016/j.respe.2017.03.133. [Epub ahead of print] French. PubMed PMID: 28576380.

7: Mason E, Pozdnyakova O, Li B, Dudley G, Dorfman DM. Flow Cytometric Patterns of CD200 and CD1d Expression Distinguish CD10-Negative, CD5-Negative Mature B-Cell Lymphoproliferative Disorders. Am J Clin Pathol. 2017 Jun 1. doi: 10.1093/ajcp/aqx041. [Epub ahead of print] PubMed PMID: 28575142.

8: Johnson EG, Albalwi AA, Al-Dabbak FM, Daher NS. Effect of Sitting Pause Times on Balance After Supine to Standing Transfer in Dim Light. J Geriatr Phys Ther. 2017 Jun 1. doi: 10.1519/JPT.0000000000000132. [Epub ahead of print] PubMed PMID: 28574915.

9: Visentin G, McParland S, De Marchi M, McDermott A, Fenelon MA, Penasa M, Berry DP. Processing characteristics of dairy cow milk are moderately heritable. J Dairy Sci. 2017 May 29. pii: S0022-0302(17)30542-8. doi: 10.3168/jds.2017-12642. [Epub ahead of print] PubMed PMID: 28571984.

10: Riedl S, Rinner B, Schaider H, Liegl-Atzwanger B, Meditz K, Preishuber-Pflügl J, Grissenberger S, Lohner K, Zweytick D. In vitro and in vivo cytotoxic activity of human lactoferricin derived antitumor peptide R-DIM-P-LF11-334 on human malignant melanoma. Oncotarget. 2017 May 11. doi: 10.18632/oncotarget.17823. [Epub ahead of print] PubMed PMID: 28570999.

11: Cuesta M, Boudreau P, Cermakian N, Boivin DB. Skin Temperature Rhythms in Humans Respond to Changes in the Timing of Sleep and Light. J Biol Rhythms. 2017 May 1:748730417702974. doi: 10.1177/0748730417702974. [Epub ahead of print] PubMed PMID: 28569119.

12: Zhang YJ, Qu W, Liu H, Wang YH, Liu CY, Li LJ, Wang HQ, Fu R, Xing LM, Shao ZH. [Research on the negative immune regulation of NK cells in patients with primary immune thrombocytopenia]. Zhonghua Xue Ye Xue Za Zhi. 2017 May 14;38(5):399-403. doi: 10.3760/cma.j.issn.0253-2727.2017.05.009. Chinese. PubMed PMID: 28565739.

13: Bobbo T, Fiore E, Gianesella M, Morgante M, Gallo L, Ruegg PL, Bittante G, Cecchinato A. Variation in blood serum proteins and association with somatic cell count in dairy cattle from multi-breed herds. Animal. 2017 May 31:1-11. doi: 10.1017/S1751731117001227. [Epub ahead of print] PubMed PMID: 28560948.

14: Thomson CA, Chow HHS, Wertheim BC, Roe DJ, Stopeck A, Maskarinec G, Altbach M, Chalasani P, Huang C, Strom MB, Galons JP, Thompson PA. A randomized, placebo-controlled trial of diindolylmethane for breast cancer biomarker modulation in patients taking tamoxifen. Breast Cancer Res Treat. 2017 May 30. doi: 10.1007/s10549-017-4292-7. [Epub ahead of print] PubMed PMID: 28560655.

15: Xiang L, Chen XJ, Wu KC, Zhang CJ, Zhou GH, Lv JN, Sun LF, Cheng FF, Cai XB, Jin ZB. miR-183/96 plays a pivotal regulatory role in mouse photoreceptor maturation and maintenance. Proc Natl Acad Sci U S A. 2017 May 30. pii: 201618757. doi: 10.1073/pnas.1618757114. [Epub ahead of print] PubMed PMID: 28559309.

16: Pode-Shakked N, Gershon R, Tam G, Omer D, Gnatek Y, Kanter I, Oriel S, Katz G, Harari-Steinberg O, Kalisky T, Dekel B. Evidence of In Vitro Preservation of Human Nephrogenesis at the Single-Cell Level. Stem Cell Reports. 2017 May 25. pii: S2213-6711(17)30180-7. doi: 10.1016/j.stemcr.2017.04.026. [Epub ahead of print] PubMed PMID: 28552604.

17: Kamata T, Giblett S, Pritchard C. KRAS(G12D) expression in lung-resident myeloid cells promotes pulmonary LCH-like neoplasm sensitive to statin treatment. Blood. 2017 May 26. pii: blood-2017-02-770149. doi: 10.1182/blood-2017-02-770149. [Epub ahead of print] PubMed PMID: 28550040.

18: Hörl S, Ejaz A, Ernst S, Mattesich M, Kaiser A, Jenewein B, Zwierzina ME, Hammerle S, Miggitsch C, Mitterberger-Vogt MC, Krautgasser C, Pierer G, Zwerschke W. CD146 (MCAM) in human cs-DLK1(-)/cs-CD34(+) adipose stromal/progenitor cells. Stem Cell Res. 2017 May 17;22:1-12. doi: 10.1016/j.scr.2017.05.004. [Epub ahead of print] PubMed PMID: 28549249.

19: El-Tarabany MS. Impact of days in milk at the initiation of ovulation synchronization protocols on the efficiency of first AI in multiparous Holstein cows. Anim Reprod Sci. 2017 May 17. pii: S0378-4320(17)30081-7. doi: 10.1016/j.anireprosci.2017.05.005. [Epub ahead of print] PubMed PMID: 28545988.

20: Theunissen PMJ, van den Branden A, Van Der Sluijs-Gelling A, De Haas V, Beishuizen A, van Dongen JJM, Van Der Velden VHJ. Understanding the reconstitution of the B-cell compartment in bone marrow and blood after treatment for B-cell precursor acute lymphoblastic leukaemia. Br J Haematol. 2017 May 25. doi: 10.1111/bjh.14685. [Epub ahead of print] PubMed PMID: 28542787.