Diethylhomospermine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 206761

CAS#: 119422-08-1

Description: Diethylhomospermine, also known as BE-4-4-4; DE-444; DEHOP; DEHSPM, is a drug potentially for the treatment of AIDS-related chronic diarrhea.Diethylhomospermine also showed promising anticancer activity.

Chemical Structure

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Diethylhomospermine
CAS# 119422-08-1
Instruction

Theoretical Analysis

MedKoo Cat#: 206761
Name: Diethylhomospermine
CAS#: 119422-08-1
Chemical Formula: C16H38N4
Exact Mass: 286.31
Molecular Weight: 286.508
Elemental Analysis: C, 67.08; H, 13.37; N, 19.56

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Diethylhomospermine; BE-4-4-4; DE-444; DEHOP; DEHSPM.

IUPAC/Chemical Name: 1,14-Bis(ethylamino)-5,10-diazatetradecane

InChi Key: QXOCYGPVDXDFLC-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H38N4/c1-3-17-11-5-7-13-19-15-9-10-16-20-14-8-6-12-18-4-2/h17-20H,3-16H2,1-2H3

SMILES Code: CCNCCCCNCCCCNCCCCNCC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 286.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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7: Bergeron RJ, Weimar WR, Luchetta G, Sninsky CA, Wiegand J. Metabolism and pharmacokinetics of N1,N14-diethylhomospermine. Drug Metab Dispos. 1996 Mar;24(3):334-43. PubMed PMID: 8820425.

8: Bergeron RJ, Wiegand J, Sninsky CA, Katovich MJ. The impact of polyamine analogues on the blood pressure of normotensive and hypertensive rats. Clin Exp Hypertens. 1995 Nov;17(8):1197-217. PubMed PMID: 8563697.

9: Chang BK, Liang Y, Miller DW, Bergeron RJ, Porter CW, Wang G. Effects of diethyl spermine analogues in human bladder cancer cell lines in culture. J Urol. 1993 Oct;150(4):1293-7. PubMed PMID: 8371417.

10: Bergeron RJ, Hawthorne TR, Vinson JR, Beck DE Jr, Ingeno MJ. Role of the methylene backbone in the antiproliferative activity of polyamine analogues on L1210 cells. Cancer Res. 1989 Jun 1;49(11):2959-64. PubMed PMID: 2720656.