Dopamine Hydrochloride | ASL-279 | Intropin | CAS#62-31-7 | Dopamine Receptor Agonist

Dopamine Hydrochloride
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 329008

CAS#: 62-31-7 (HCl)

Description: Dopamine Hydrochloride, also known as ASL-279 and Intropin, is an inotropic vasopressor agent and dopamine receptor agonist used in neurological diseases. Dopamine catecholamine neurotransmitter in the extrapyramidal system of the brain and important in regulating movement. Dopamine Hydrochloride used to treat acute heart failure, myocardial infarction and renal failure.

Chemical Structure

Dopamine Hydrochloride

CAS# 62-31-7 (HCl)

Instruction

Theoretical Analysis

MedKoo Cat#: 329008
Name: Dopamine Hydrochloride
CAS#: 62-31-7 (HCl)
Chemical Formula: C8H12ClNO2
Exact Mass: 0.00
Molecular Weight: 189.639
Elemental Analysis: C, 50.67; H, 6.38; Cl, 18.69; N, 7.39; O, 16.87

Price and Availability

Size	Price	Availability
5g	USD 250	2 Weeks
25g	USD 450	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Related CAS #: 62-31-7 (HCl); 51-61-6 (free base)

Synonym: Dopamine Hydrochloride; ASL-279; ASL 279; ASL279; Intropin; P 498; P-498; P498

IUPAC/Chemical Name: 4-(2-aminoethyl)benzene-1,2-diol hydrochloride

InChi Key: CTENFNNZBMHDDG-UHFFFAOYSA-N

InChi Code: InChI=1S/C8H11NO2.ClH/c9-4-3-6-1-2-7(10)8(11)5-6;/h1-2,5,10-11H,3-4,9H2;1H

SMILES Code: OC1=CC=C(CCN)C=C1O.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: Related CAS# 62-31-7 (Dopamine Hydrochloride) 51-61-6 (Dopamine)

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 189.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Khan MS, Pandey S, Talib A, Bhaisare ML, Wu HF. Controlled delivery of dopamine hydrochloride using surface modified carbon dots for neuro diseases. Colloids Surf B Biointerfaces. 2015 Oct 1;134:140-6. doi: 10.1016/j.colsurfb.2015.06.006. Epub 2015 Jun 19. PubMed PMID: 26186107.

2: Zhai C, Li D, Li L, Sun F, Ma H, Liu X. Experimental and theoretical study on the hydrogen bonding between dopamine hydrochloride and N,N-dimethyl formamide. Spectrochim Acta A Mol Biomol Spectrosc. 2015 Jun 15;145:500-4. doi: 10.1016/j.saa.2015.03.024. Epub 2015 Mar 12. Erratum in: Spectrochim Acta A Mol Biomol Spectrosc. 2015 Nov;150:1015. PubMed PMID: 25801441.

3: Xiao XD, Shi L, Guo LH, Wang JW, Zhang X. Determination of dopamine hydrochloride by host-guest interaction based on water-soluble pillar[5]arene. Spectrochim Acta A Mol Biomol Spectrosc. 2016 Aug 27;173:6-12. doi: 10.1016/j.saa.2016.08.050. [Epub ahead of print] PubMed PMID: 27588725.

4: Gosliga JM, Barter LS. Cardiovascular effects of dopamine hydrochloride and phenylephrine hydrochloride in healthy isoflurane-anesthetized New Zealand White rabbits (Oryctolagus cuniculus). Am J Vet Res. 2015 Feb;76(2):116-21. doi: 10.2460/ajvr.76.2.116. PubMed PMID: 25629908.

5: Callear SK, Johnston A, McLain SE, Imberti S. Conformation and interactions of dopamine hydrochloride in solution. J Chem Phys. 2015 Jan 7;142(1):014502. doi: 10.1063/1.4904291. PubMed PMID: 25573567.

6: Di Gioia S, Trapani A, Mandracchia D, De Giglio E, Cometa S, Mangini V, Arnesano F, Belgiovine G, Castellani S, Pace L, Lavecchia MA, Trapani G, Conese M, Puglisi G, Cassano T. Intranasal delivery of dopamine to the striatum using glycol chitosan/sulfobutylether-β-cyclodextrin based nanoparticles. Eur J Pharm Biopharm. 2015 Aug;94:180-93. doi: 10.1016/j.ejpb.2015.05.019. Epub 2015 May 30. PubMed PMID: 26032293.

7: Hong JM, Cho AR, Choi SA. Accidental intrathecal injection of dopamine hydrochloride resulting in analgesic effects. Korean J Anesthesiol. 2014 Dec;67(Suppl):S49-50. doi: 10.4097/kjae.2014.67.S.S49. PubMed PMID: 25598904; PubMed Central PMCID: PMC4295978.

8: Achterberg EJ, van Kerkhof LW, Servadio M, van Swieten MM, Houwing DJ, Aalderink M, Driel NV, Trezza V, Vanderschuren LJ. Contrasting Roles of Dopamine and Noradrenaline in the Motivational Properties of Social Play Behavior in Rats. Neuropsychopharmacology. 2016 Feb;41(3):858-68. doi: 10.1038/npp.2015.212. PubMed PMID: 26174597; PubMed Central PMCID: PMC4707831.

9: Mercante LA, Pavinatto A, Iwaki LE, Scagion VP, Zucolotto V, Oliveira ON Jr, Mattoso LH, Correa DS. Electrospun polyamide 6/poly(allylamine hydrochloride) nanofibers functionalized with carbon nanotubes for electrochemical detection of dopamine. ACS Appl Mater Interfaces. 2015 Mar 4;7(8):4784-90. doi: 10.1021/am508709c. Epub 2015 Feb 17. PubMed PMID: 25644325.

10: Wang W, Zhao L, Bai F, Zhang T, Dong H, Liu L. The protective effect of dopamine against OGD/R injury-induced cell death in HT22 mouse hippocampal cells. Environ Toxicol Pharmacol. 2016 Mar;42:176-82. doi: 10.1016/j.etap.2016.01.020. Epub 2016 Jan 27. PubMed PMID: 26867202.

11: Li H, Wu X. Silver nanoparticles-enhanced rare earth co-luminescence effect of Tb(III)-Y(III)-dopamine system. Talanta. 2015 Jun 1;138:203-8. doi: 10.1016/j.talanta.2015.02.023. Epub 2015 Feb 20. PubMed PMID: 25863392.

12: Krishna G, Gopalakrishnan G, Goel S. In vitro and in vivo genotoxicity assessment of the dopamine receptor antagonist molindone hydrochloride. Environ Mol Mutagen. 2016 May;57(4):288-98. doi: 10.1002/em.22007. Epub 2016 Apr 4. PubMed PMID: 27040600.

13: Mohamed GG, Nour el-Dien FA, el-Nahas RG. New copper(II) complexes with dopamine hydrochloride and vanillymandelic acid: spectroscopic and thermal characterization. Spectrochim Acta A Mol Biomol Spectrosc. 2011 Oct 15;81(1):489-97. doi: 10.1016/j.saa.2011.06.042. Epub 2011 Jun 23. PubMed PMID: 21795104.

14: Wu SF, Xu G, Stanley D, Huang J, Ye GY. Dopamine modulates hemocyte phagocytosis via a D1-like receptor in the rice stem borer, Chilo suppressalis. Sci Rep. 2015 Jul 16;5:12247. doi: 10.1038/srep12247. PubMed PMID: 26179416; PubMed Central PMCID: PMC4503959.

15: Cho S, Kim SH. Hydroxide ion-mediated synthesis of monodisperse dopamine-melanin nanospheres. J Colloid Interface Sci. 2015 Nov 15;458:87-93. doi: 10.1016/j.jcis.2015.06.051. Epub 2015 Jul 10. PubMed PMID: 26210098.

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