PD 109488
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525816

CAS#: 103733-49-9

Description: PD 109488 is a metabolite of quinapril. PD 109488, otherwise known as Quinapril Diketopiperazine, is a derivative of Quinapril that acts as an ACE inhibitor. Inhibition of ACE prevents the conversion of signaling peptide angiotensin I into angiotensin II, which acts as a potent vasoconstrictor. Reduced levels of angiotensin II also reduces the amount of aldosterone that is expressed due to RAAS signaling.

Chemical Structure

img
PD 109488
CAS# 103733-49-9
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 525816
Name: PD 109488
CAS#: 103733-49-9
Chemical Formula: C25H28N2O4
Exact Mass: 420.20
Molecular Weight: 420.501
Elemental Analysis: C, 71.41; H, 6.71; N, 6.66; O, 15.22

Price and Availability

Size Price Availability Quantity
50mg USD 1340
Bulk inquiry

Synonym: Quinapril Diketopiperazine; PD-109488; PD109488; PD 109488

IUPAC/Chemical Name: (S)-ethyl 2-((3S,11aS)-3-methyl-1,4-dioxo-3,4,11,11a-tetrahydro-1H-pyrazino[1,2-b]isoquinolin-2(6H)-yl)-4-phenylbutanoate

InChi Key: NDDYKENLGBOEPD-HSQYWUDLSA-N

InChi Code: InChI=1S/C25H28N2O4/c1-3-31-25(30)21(14-13-18-9-5-4-6-10-18)27-17(2)23(28)26-16-20-12-8-7-11-19(20)15-22(26)24(27)29/h4-12,17,21-22H,3,13-16H2,1-2H3/t17-,21-,22-/m0/s1

SMILES Code: O=C(OCC)[C@@H](N([C@@H](C)C1=O)C([C@@]2([H])N1CC3=C(C=CC=C3)C2)=O)CCC4=CC=CC=C4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Product Data
Instruction:
View handling instruction
Biological target: PD 109488, otherwise known as Quinapril Diketopiperazine, is a derivative of Quinapril that acts as an ACE inhibitor.
In vitro activity: TBD
In vivo activity: TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 420.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: TBD
In vitro protocol: TBD
In vivo protocol: TBD

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

http://www.scbt.com/datasheet-208192-quinapril-diketopiperazine.html