Chloramphenicol palmitate | CAS#530-43-8 (palmitate) | Antibacterial

Chloramphenicol palmitate
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 592235

CAS#: 530-43-8 (palmitate)

Description: Chloramphenicol palmitate is an Antibacterial and Antirickettsial.

Chemical Structure

Chloramphenicol palmitate

CAS# 530-43-8 (palmitate)

Product data Instruction

Theoretical Analysis

MedKoo Cat#: 592235
Name: Chloramphenicol palmitate
CAS#: 530-43-8 (palmitate)
Chemical Formula: C27H42Cl2N2O6
Exact Mass: 560.24
Molecular Weight: 561.541
Elemental Analysis: C, 57.75; H, 7.54; Cl, 12.63; N, 4.99; O, 17.09

Price and Availability

Size	Price	Availability
1g	USD 150	Ready to ship
2g	USD 250	Ready to ship
5g	USD 450	Ready to ship
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Chloramphenicol palmitate; Chloramphenicol Palmitate Nonpolymorph A;

IUPAC/Chemical Name: Hexadecanoic acid, 2-((2,2-dichloroacetyl)amino)-3-hydroxy-3-(4-nitrophenyl) propyl ester, (R-(R*,R*))-

InChi Key: PXKHGMGELZGJQE-ILBGXUMGSA-N

InChi Code: InChI=1S/C27H42Cl2N2O6/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-24(32)37-20-23(30-27(34)26(28)29)25(33)21-16-18-22(19-17-21)31(35)36/h16-19,23,25-26,33H,2-15,20H2,1H3,(H,30,34)/t23-,25-/m1/s1

SMILES Code: CCCCCCCCCCCCCCCC(OC[C@@H](NC(C(Cl)Cl)=O)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2941.40.0000

More Info:

Product Data:

Product Data

Certificate of Analysis:

View CoA: current batch, Lot#A22T12K29

QC Data:

View QC data: current batch, Lot#A22T12K29

Safety Data Sheet (SDS):

View Safety Data Sheet (SDS)

Instruction:

View handling instruction

Biological target:	Chloramphenicol palmitate can be used as bacterial selection agent in transformed cells containing chloramphenicol resistance genes.
In vitro activity:	The germination percentage and germ-tube length were not affected by Cm (chloramphenicol), whereas the percentage of appressorium formation was significantly and specifically decreased in the presence of 30 and 300 µM Cm (Fig. 1). Addition of excessive Cm (3000 µM) resulted in inhibition of conidial germination and/or germ-tube elongation, which suggested that this Cm concentration inhibited the mitochondrial ribosome (Fig. S1). Reference: Sci Rep. 2019 Jun 26;9(1):9283. https://pubmed.ncbi.nlm.nih.gov/31243315/
In vivo activity:	All results indicated that an intra-articular injection of chloramphenicol increased chondrocyte autophagy in rabbits with collagenase-induced OA (osteoarthritis). Reference: Clin Orthop Relat Res. 2019 Dec;477(12):2785-2797. https://pubmed.ncbi.nlm.nih.gov/31764352/

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	100.0	178.08

Preparing Stock Solutions

The following data is based on the product molecular weight 561.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:	1. Nozaka A, Nishiwaki A, Nagashima Y, Endo S, Kuroki M, Nakajima M, Narukawa M, Kamisuki S, Arazoe T, Taguchi H, Sugawara F, Kamakura T. Chloramphenicol inhibits eukaryotic Ser/Thr phosphatase and infection-specific cell differentiation in the rice blast fungus. Sci Rep. 2019 Jun 26;9(1):9283. doi: 10.1038/s41598-019-41039-x. PMID: 31243315; PMCID: PMC6594944. 2. Louzoun Zada S, Green KD, Shrestha SK, Herzog IM, Garneau-Tsodikova S, Fridman M. Derivatives of Ribosome-Inhibiting Antibiotic Chloramphenicol Inhibit the Biosynthesis of Bacterial Cell Wall. ACS Infect Dis. 2018 Jul 13;4(7):1121-1129. doi: 10.1021/acsinfecdis.8b00078. Epub 2018 May 1. PMID: 29714997; PMCID: PMC6536003. 3. Wu X, Cai Y, Lu S, Xu K, Shi X, Yang L, Huang Z, Xu P. Intra-articular Injection of Chloramphenicol Reduces Articular Cartilage Degeneration in a Rabbit Model of Osteoarthritis. Clin Orthop Relat Res. 2019 Dec;477(12):2785-2797. doi: 10.1097/CORR.0000000000001016. PMID: 31764352; PMCID: PMC6907289. 4. Hsu CY, Yang SC, Sung CT, Weng YH, Fang JY. Anti-MRSA malleable liposomes carrying chloramphenicol for ameliorating hair follicle targeting. Int J Nanomedicine. 2017 Nov 10;12:8227-8238. doi: 10.2147/IJN.S147226. PMID: 29184410; PMCID: PMC5689027.
In vitro protocol:	1. Nozaka A, Nishiwaki A, Nagashima Y, Endo S, Kuroki M, Nakajima M, Narukawa M, Kamisuki S, Arazoe T, Taguchi H, Sugawara F, Kamakura T. Chloramphenicol inhibits eukaryotic Ser/Thr phosphatase and infection-specific cell differentiation in the rice blast fungus. Sci Rep. 2019 Jun 26;9(1):9283. doi: 10.1038/s41598-019-41039-x. PMID: 31243315; PMCID: PMC6594944. 2. Louzoun Zada S, Green KD, Shrestha SK, Herzog IM, Garneau-Tsodikova S, Fridman M. Derivatives of Ribosome-Inhibiting Antibiotic Chloramphenicol Inhibit the Biosynthesis of Bacterial Cell Wall. ACS Infect Dis. 2018 Jul 13;4(7):1121-1129. doi: 10.1021/acsinfecdis.8b00078. Epub 2018 May 1. PMID: 29714997; PMCID: PMC6536003.
In vivo protocol:	1. Wu X, Cai Y, Lu S, Xu K, Shi X, Yang L, Huang Z, Xu P. Intra-articular Injection of Chloramphenicol Reduces Articular Cartilage Degeneration in a Rabbit Model of Osteoarthritis. Clin Orthop Relat Res. 2019 Dec;477(12):2785-2797. doi: 10.1097/CORR.0000000000001016. PMID: 31764352; PMCID: PMC6907289. 2. Hsu CY, Yang SC, Sung CT, Weng YH, Fang JY. Anti-MRSA malleable liposomes carrying chloramphenicol for ameliorating hair follicle targeting. Int J Nanomedicine. 2017 Nov 10;12:8227-8238. doi: 10.2147/IJN.S147226. PMID: 29184410; PMCID: PMC5689027.

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