NT160 HCl

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MedKoo CAT#: 130510

CAS#: NT160 HCl

Description: NT160 is highly potent class-IIa histone deacetylase probe. Radio-labed [18F]-NT160 is a diagnostic tool for positron emission tomography (PET). [18F]-NT160 can cross the blood brain barrier and bind to class-IIa HDACs in vivo. PET imaging with [18F]NT160, a highly potent class-IIa HDAC inhibitor, led to high-quality and high-contrast images of the brain. [18F]NT160 displayed excellent pharmacokinetic and imaging characteristics: brain uptake is high in gray matter regions, tissue kinetics are appropriate for a 18F-tracer, and specific binding for class-IIa HDACs is demonstrated by self-blockade. Note: This product we are supplying is not radiolabeled.

Chemical Structure

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NT160 HCl
CAS# NT160 HCl
Instruction

Theoretical Analysis

MedKoo Cat#: 130510
Name: NT160 HCl
CAS#: NT160 HCl
Chemical Formula: C21H22ClF3N4O2
Exact Mass: 0.00
Molecular Weight: 454.878
Elemental Analysis: C, 55.45; H, 4.88; Cl, 7.79; F, 12.53; N, 12.32; O, 7.03

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 1418293-40-9 (free base)   NT160 HCl    

Synonym: NT160 HCl; NT160 hydrochloride, NT 160; NT-160; NT160;

IUPAC/Chemical Name: (R)-N-(1-(Benzyl(methyl)amino)propan-2-yl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide hydrochloride

InChi Key: NUHXHKRXVDGRNM-PFEQFJNWSA-N

InChi Code: InChI=1S/C21H21F3N4O2.ClH/c1-14(12-28(2)13-15-6-4-3-5-7-15)25-19(29)17-10-8-16(9-11-17)18-26-20(30-27-18)21(22,23)24;/h3-11,14H,12-13H2,1-2H3,(H,25,29);1H/t14-;/m1./s1

SMILES Code: O=C(N[C@H](C)CN(CC1=CC=CC=C1)C)C2=CC=C(C3=NOC(C(F)(F)F)=N3)C=C2.[H]Cl

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 454.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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