Cicletanine (free base)

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 412883

CAS#: 89943-82-8 (free base)

Description: Cicletanine (free base) is a furopyridine low-ceiling diuretic drug, usually used in the treatment of hypertension. The drug is manufactured by Ipsen and marketed by Recordati under the trade name Tenstaten. It appears to be more potent in salt-sensitive hypertension.

Chemical Structure

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Cicletanine (free base)
CAS# 89943-82-8 (free base)
Instruction

Theoretical Analysis

MedKoo Cat#: 412883
Name: Cicletanine (free base)
CAS#: 89943-82-8 (free base)
Chemical Formula: C14H12ClNO2
Exact Mass: 261.06
Molecular Weight: 261.710
Elemental Analysis: C, 64.25; H, 4.62; Cl, 13.55; N, 5.35; O, 12.23

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 82747-56-6 (HCl)   89943-82-8 (free base)  

Synonym: Cicletanine (free base); Win90,000; Win-90,000; Win 90,000

IUPAC/Chemical Name: 3-(4-chlorophenyl)-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol

InChi Key: CVKNDPRBJVBDSS-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H12ClNO2/c1-8-13(17)12-7-18-14(11(12)6-16-8)9-2-4-10(15)5-3-9/h2-6,14,17H,7H2,1H3

SMILES Code: Cc1c(O)c2c(C(c3ccc(Cl)cc3)OC2)cn1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 261.71 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Choi EY, Ro Y, Choi JW, Kang CM, Kim GH. Cicletanine-induced hyponatremia and hypokalemia in kidney transplant patients. Kidney Res Clin Pract. 2016 Sep;35(3):142-6. doi: 10.1016/j.krcp.2016.05.004. Epub 2016 May 25. PMID: 27668156; PMCID: PMC5025466.

2: Kalinowski L, Szczepańska-Konkel M, Jankowski M, Angielski S. Cicletanine: new insights into its pharmacological actions. Gen Pharmacol. 1999 Jul;33(1):7-16. doi: 10.1016/s0306-3623(98)00257-2. PMID: 10428010.

3: Ferdinandy P, Koltai M, Tosaki A, Berthet P, Tarrade T, Esanu A, Braquet P. Cicletanine improves myocardial function deteriorated by ischemia/reperfusion in isolated working rat hearts. J Cardiovasc Pharmacol. 1992 Feb;19(2):181-9. doi: 10.1097/00005344-199202000-00005. PMID: 1376786.

4: Menard C, Lamiable D, Vistelle R, Droy-Lefait MT, Ratanasavanh D. Effects of oxazepam and acetaminophen on cicletanine metabolism in rat hepatocytes and liver microsomes. Fundam Clin Pharmacol. 1999;13(5):571-6. doi: 10.1111/j.1472-8206.1999.tb00363.x. PMID: 10520730.

5: Nakamoto H, Suzuki H, Ohishi A, Katsumata H, Sakaguchi H, Saruta T. Effects of cicletanine on the progression of renal failure in 5/6 nephrectomized hypertensive rats. Clin Exp Pharmacol Physiol. 1999 Mar;26(3):236-41. doi: 10.1046/j.1440-1681.1999.03021.x. PMID: 10081620.

6: Zini R, Morin D, Jouenne P, Tillement JP. Cicletanine binding to human plasma proteins and erythrocytes, a particular HSA-drug interaction. Life Sci. 1988;43(25):2103-15. doi: 10.1016/0024-3205(88)90360-8. PMID: 3210902.

7: Liu S, Rockey DC. Cicletanine stimulates eNOS phosphorylation and NO production via Akt and MAP kinase/Erk signaling in sinusoidal endothelial cells. Am J Physiol Gastrointest Liver Physiol. 2013 Jul 15;305(2):G163-71. doi: 10.1152/ajpgi.00003.2013. Epub 2013 May 2. PMID: 23639812; PMCID: PMC3725686.

8: Wagner F, Malice MP, Wiegert E, McGrath HE, Gildea J, Mitta S, Van Dyck K, De Lepeleire I, Johnson-Levonas AO, Sisk CM, Fernandez R, Greenwalt DM, Beals C, Carey RM, Nunes I. A comparison of the natriuretic and kaliuretic effects of cicletanine and hydrochlorothiazide in prehypertensive and hypertensive humans. J Hypertens. 2012 Apr;30(4):819-27. doi: 10.1097/HJH.0b013e32835022a8. PMID: 22278145.

9: Chabrier PE, Esanu A, Braquet P. Vascular remodeling and antihypertensive therapy: the example of cicletanine. J Cardiovasc Pharmacol. 1993;21 Suppl 1:S50-3. doi: 10.1097/00005344-199321001-00008. PMID: 7681131.

10: Bagrov AY, Dmitrieva RI, Dorofeeva NA, Fedorova OV, Lopatin DA, Lakatta EG, Droy-Lefaix MT. Cicletanine reverses vasoconstriction induced by the endogenous sodium pump ligand, marinobufagenin, via a protein kinase C dependent mechanism. J Hypertens. 2000 Feb;18(2):209-15. doi: 10.1097/00004872-200018020-00012. PMID: 10694190.