BT44 | CAS#924759-42-2

BT44
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 535272

CAS#: 924759-42-2

Description: BT44 is a novel RET agonist for the treatment of experimental neuropathies.

Chemical Structure

BT44

CAS# 924759-42-2

Instruction

Theoretical Analysis

MedKoo Cat#: 535272
Name: BT44
CAS#: 924759-42-2
Chemical Formula: C28H27F4N3O4S
Exact Mass: 577.17
Molecular Weight: 577.595
Elemental Analysis: C, 58.23; H, 4.71; F, 13.16; N, 7.28; O, 11.08; S, 5.55

Price and Availability

Size	Price	Availability
25mg	USD 450	2 Weeks
50mg	USD 750	2 Weeks
100mg	USD 1250	2 Weeks
1g	USD 4650	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Related CAS #: 924759-42-2

Synonym: BT44; BT-44; BT 44

IUPAC/Chemical Name: (4-(5-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)-2-methoxyphenyl)piperazin-1-yl)(4-fluoro-2-(trifluoromethyl)phenyl)methanone

InChi Key: MFQBJWVTKPJNEP-UHFFFAOYSA-N

InChi Code: InChI=1S/C28H27F4N3O4S/c1-39-26-9-7-22(40(37,38)35-11-10-19-4-2-3-5-20(19)18-35)17-25(26)33-12-14-34(15-13-33)27(36)23-8-6-21(29)16-24(23)28(30,31)32/h2-9,16-17H,10-15,18H2,1H3

SMILES Code: O=C(N1CCN(C2=CC(S(=O)(N3CC4=C(C=CC=C4)CC3)=O)=CC=C2OC)CC1)C5=CC=C(F)C=C5C(F)(F)F

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 577.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Sverchinsky DV, Nikotina AD, Komarova EY, Mikhaylova ER, Aksenov ND, Lazarev VF, Mitkevich VA, Suezov R, Druzhilovskiy DS, Poroikov VV, Margulis BA, Guzhova IV. Etoposide-Induced Apoptosis in Cancer Cells Can Be Reinforced by an Uncoupled Link between Hsp70 and Caspase-3. Int J Mol Sci. 2018 Aug 25;19(9):2519. doi: 10.3390/ijms19092519. PMID: 30149619; PMCID: PMC6163214.

2: Viisanen H, Nuotio U, Kambur O, Mahato AK, Jokinen V, Lilius T, Li W, Santos HA, Karelson M, Rauhala P, Kalso E, Sidorova YA. Novel RET agonist for the treatment of experimental neuropathies. Mol Pain. 2020 Jan- Dec;16:1744806920950866. doi: 10.1177/1744806920950866. PMID: 32811276.

3: Burr DH, Rollins D, Lee LH, Pattarini DL, Walz SS, Tian JH, Pace JL, Bourgeois AL, Walker RI. Prevention of disease in ferrets fed an inactivated whole cell Campylobacter jejuni vaccine. Vaccine. 2005 Jul 29;23(34):4315-21. doi: 10.1016/j.vaccine.2005.03.038. PMID: 16005742.

4: Hickey TE, Baqar S, Bourgeois AL, Ewing CP, Guerry P. Campylobacter jejuni- stimulated secretion of interleukin-8 by INT407 cells. Infect Immun. 1999 Jan;67(1):88-93. doi: 10.1128/IAI.67.1.88-93.1999. PMID: 9864200; PMCID: PMC96281.

5: McGavock H. Strategies and tactics for effective prescribing during the foundation year. Br J Hosp Med (Lond). 2005 Aug;66(8):Suppl M3-4. doi: 10.12968/hmed.2005.66.Sup1.18523. PMID: 16097522.

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