Lysylproline

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530700

CAS#: 52766-27-5 (free base)

Description: Lysylproline Third & fourth amino acid in substance P sequence.

Chemical Structure

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Lysylproline
CAS# 52766-27-5 (free base)
Instruction

Theoretical Analysis

MedKoo Cat#: 530700
Name: Lysylproline
CAS#: 52766-27-5 (free base)
Chemical Formula: C11H21N3O3
Exact Mass: 243.16
Molecular Weight: 243.307
Elemental Analysis: C, 54.30; H, 8.70; N, 17.27; O, 19.73

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Related CAS #: 106356-78-9 (HCl)   143983-32-8 (2HCl)   52766-27-5 (free base)   115655-94-2 (HBr)    

Synonym: Lysylproline

IUPAC/Chemical Name: L-Proline, 1-L-lysyl-

InChi Key: AIXUQKMMBQJZCU-IUCAKERBSA-N

InChi Code: InChI=1S/C11H21N3O3/c12-6-2-1-4-8(13)10(15)14-7-3-5-9(14)11(16)17/h8-9H,1-7,12-13H2,(H,16,17)/t8-,9-/m0/s1

SMILES Code: O=C(O)[C@H]1N(C([C@H](CCCCN)N)=O)CCC1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 243.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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6: Marino AM, Chong S, Dando SA, Kripalani KJ, Bathala MS, Morrison RA. Distribution of the dipeptide transporter system along the gastrointestinal tract of rats based on absorption of a stable and specific probe, SQ-29852. J Pharm Sci. 1996 Mar;85(3):282-6. PubMed PMID: 8699329.

7: Uehara Y, Shimizu H, Sato N, Mura YS, Mori M. The dipeptide Lys-Pro attenuates interleukin-1 beta-induced anorexia. Peptides. 1993 Mar-Apr;14(2):175-8. PubMed PMID: 8387184.

8: Katinas GS, Petriaeva MA. [The dynamics of the reparative regeneration of the rat epidermis exposed to lysylproline]. Morfologiia. 1992 May;102(5):106-12. Russian. PubMed PMID: 1285287.

9: Kieliszewski MJ, Leykam JF, Lamport DT. Trypsin cleaves lysylproline in a hydroxyproline-rich glycoprotein from Zea mays. Pept Res. 1989 May-Jun;2(3):246-8. PubMed PMID: 2520761.

10: Kohl A, Volk HD, Diezel W, Buntrock P, Diamantstein T. The dipeptide Lys-Pro restores the diminished wound healing following treatment with anti-T-helper cell monoclonal antibody. Int J Immunopharmacol. 1989;11(3):237-40. PubMed PMID: 2525534.

11: Karanewsky DS, Badia MC, Cushman DW, DeForrest JM, Dejneka T, Loots MJ, Perri MG, Petrillo EW Jr, Powell JR. (Phosphinyloxy)acyl amino acid inhibitors of angiotensin converting enzyme (ACE). 1. Discovery of (S)-1-[6-amino-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxohexyl]-L -proline a novel orally active inhibitor of ACE. J Med Chem. 1988 Jan;31(1):204-12. PubMed PMID: 3336020.

12: Nausch I, Heymann E. Substance P in human plasma is degraded by dipeptidyl peptidase IV, not by cholinesterase. J Neurochem. 1985 May;44(5):1354-7. PubMed PMID: 2580948.

13: Lindner G, Grosse G. [Morphological studies of the effect of substance P partial sequences on nerve tissue culture]. Z Mikrosk Anat Forsch. 1983;97(1):65-74. German. PubMed PMID: 6195835.