WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 526727
Description: HCV-371 is a potent and selective HCV NS5B polymerase inhibitor. HCV-371 displayed broad inhibitory activities against the NS5B RdRp enzyme, with 50% inhibitory concentrations ranging from 0.3 to 1.8 microM for 90% of the isolates derived from HCV genotypes 1a, 1b, and 3a. HCV-371 showed no inhibitory activity against a panel of human polymerases, including mitochondrial DNA polymerase gamma, and other unrelated viral polymerases, demonstrating its specificity for the HCV polymerase. Fluorescence binding studies show that HCV-371 binds the NS5B with an apparent dissociation constant of 150 nM, leading to high selectivity and lack of cytotoxicity in the antiviral assays.
MedKoo Cat#: 526727
Chemical Formula: C18H20N2O3
Exact Mass: 312.1474
Molecular Weight: 312.369
Elemental Analysis: C, 69.21; H, 6.45; N, 8.97; O, 15.37
This product is not in stock, which may be available by custom synthesis.
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Synonym: HCV-371; HCV 371; HCV371.
IUPAC/Chemical Name: (R)-2-(5-cyano-8-methyl-1-propyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid
InChi Key: JXZYSNWHGBGZAI-GOSISDBHSA-N
InChi Code: InChI=1S/C18H20N2O3/c1-3-7-18(9-14(21)22)17-13(6-8-23-18)15-12(10-19)5-4-11(2)16(15)20-17/h4-5,20H,3,6-9H2,1-2H3,(H,21,22)/t18-/m1/s1
SMILES Code: N#CC1=CC=C(C(N2)=C1C3=C2[C@](CCC)(OCC3)CC(O)=O)C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 312.369 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Gopalsamy A, Lim K, Ciszewski G, Park K, Ellingboe JW, Bloom J, Insaf S,
Upeslacis J, Mansour TS, Krishnamurthy G, Damarla M, Pyatski Y, Ho D, Howe AY,
Orlowski M, Feld B, O'Connell J. Discovery of pyrano[3,4-b]indoles as potent and
selective HCV NS5B polymerase inhibitors. J Med Chem. 2004 Dec 16;47(26):6603-8.
PubMed PMID: 15588095.
2: Howe AY, Bloom J, Baldick CJ, Benetatos CA, Cheng H, Christensen JS, Chunduru
SK, Coburn GA, Feld B, Gopalsamy A, Gorczyca WP, Herrmann S, Johann S, Jiang X,
Kimberland ML, Krisnamurthy G, Olson M, Orlowski M, Swanberg S, Thompson I, Thorn
M, Del Vecchio A, Young DC, van Zeijl M, Ellingboe JW, Upeslacis J, Collett M,
Mansour TS, O'Connell JF. Novel nonnucleoside inhibitor of hepatitis C virus
RNA-dependent RNA polymerase. Antimicrob Agents Chemother. 2004
Dec;48(12):4813-21. PubMed PMID: 15561861; PubMed Central PMCID: PMC529219.