Flindokalner
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MedKoo CAT#: 525063

CAS#: 187523-35-9

Description: Flindokalner, also known BMS-204352, is a neuroprotectant. It is an opener of large conductance and calcium-activated (Maxi-K) K(sup +) channels. In vitro, acute BMS-204352 treatment (10 μM) restored the abnormal dendritic spine phenotype. In vivo, a single injection of BMS-204352 (2 mg/kg) rescued the hippocampal glutamate homeostasis and the behavioral phenotype. Indeed, disturbances in social recognition and interaction, non-social anxiety, and spatial memory were corrected by BMS-204352 in Fmr1 KO mice.


Chemical Structure

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Flindokalner
CAS# 187523-35-9

Theoretical Analysis

MedKoo Cat#: 525063
Name: Flindokalner
CAS#: 187523-35-9
Chemical Formula: C16H10ClF4NO2
Exact Mass: 359.03
Molecular Weight: 359.700
Elemental Analysis: C, 53.43; H, 2.80; Cl, 9.86; F, 21.13; N, 3.89; O, 8.90

Price and Availability

Size Price Availability Quantity
25mg USD 550 2 Weeks
50mg USD 950 2 Weeks
100mg USD 1450 2 Weeks
200mg USD 2450 2 Weeks
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Synonym: Flindokalner; BMS-204352; BMS 204352; BMS204352; MaxiPost.

IUPAC/Chemical Name: (3S)-3-(5-Chloro-2-methoxyphenyl)-3-fluoro-6-(trifluoromethyl)-1,3-dihydro-2H-indol-2-one

InChi Key: ULYONBAOIMCNEH-HNNXBMFYSA-N

InChi Code: InChI=1S/C16H10ClF4NO2/c1-24-13-5-3-9(17)7-11(13)15(18)10-4-2-8(16(19,20)21)6-12(10)22-14(15)23/h2-7H,1H3,(H,22,23)/t15-/m0/s1

SMILES Code: O=C1NC2=C(C=CC(C(F)(F)F)=C2)[C@@]1(C3=CC(Cl)=CC=C3OC)F

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 359.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Young BL, Cooks RG, Madden MC, Bair M, Jia J, Aubry AF, Miller SA. Chiral purity assay for Flindokalner using tandem mass spectrometry: method development, validation, and benchmarking. J Pharm Biomed Anal. 2007 Apr 11;43(5):1602-8. Epub 2007 Jan 8. PubMed PMID: 17298872.