Fenclonine
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 525042

CAS#: 7424-00-2

Description: Fenclonine acts as a selective and irreversible inhibitor of tryptophan hydroxylase, which is a rate-limiting enzyme in the biosynthesis of serotonin. It has been used experimentally to treat carcinoid syndrome.


Chemical Structure

img
Fenclonine
CAS# 7424-00-2

Theoretical Analysis

MedKoo Cat#: 525042
Name: Fenclonine
CAS#: 7424-00-2
Chemical Formula: C9H10ClNO2
Exact Mass: 199.04
Molecular Weight: 199.630
Elemental Analysis: C, 54.15; H, 5.05; Cl, 17.76; N, 7.02; O, 16.03

Price and Availability

Size Price Availability Quantity
1g USD 90 Ready to ship
5g USD 150 Ready to ship
10g USD 250 Ready to ship
25g USD 450 2 Weeks
Bulk inquiry

Related CAS #: 23633-07-0 (HCl)   7424-00-2  

Synonym: CP-10,188; CP10,188; CP 10,188; CP-10188; CP10188; CP 10188; Fenclonine; DL-3-(4-Chlorophenyl)alanine; Fenclonin; NSC 77370; p-Clorophenylalanine.

IUPAC/Chemical Name: Alanine, 3-(4-chlorophenyl)-, DL-

InChi Key: NIGWMJHCCYYCSF-UHFFFAOYSA-N

InChi Code: InChI=1S/C9H10ClNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)

SMILES Code: C(C(=O)O)(Cc1ccc(cc1)Cl)N

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Safety Data Sheet (SDS):
Biological target: Fenclonine is an irreversible inhibitor of tryptophan (Trp) hydroxylase, the rate-limiting enzyme in serotonin biosynthesis.
In vitro activity: N/A
In vivo activity: N/A

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 1.5 7.51
Water 2.0 10.02

Preparing Stock Solutions

The following data is based on the product molecular weight 199.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: TBD
In vitro protocol: TBD
In vivo protocol: TBD

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Sicuteri F, Rumboldt Z, del Bene E. [Does fenclonine open up new perspectives in the treatment of impotence?]. Lijec Vjesn. 1975 May;97(5):307-10. Croatian. PubMed PMID: 128680.

2: Cremata VY Jr, Koe BK. Clinical and biochemical effects of fenclonine: a serotonin depletor. Dis Nerv Syst. 1968 May;29(5):Suppl:147-52. PubMed PMID: 5673619.