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MedKoo CAT#: 318455

CAS#: 115-67-3

Description: Paramethadione is an anticonvulsant agent in the oxazolidinedione class.

Price and Availability

Size Price Shipping out time Quantity
100mg USD 250 2 Weeks
200mg USD 450 2 Weeks
500mg USD 650 2 Weeks
1g USD 950 2 Weeks
2g USD 1750 2 Weeks
5g USD 2850 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-07-11. Prices are subject to change without notice.

Paramethadione, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 318455
Name: Paramethadione
CAS#: 115-67-3
Chemical Formula: C7H11NO3
Exact Mass: 157.07389
Molecular Weight: 157.17
Elemental Analysis: C, 53.49; H, 7.05; N, 8.91; O, 30.54

Synonym: Paramethadione; BRN 0127715; EINECS 204-098-8; HSDB 3245; Isoethadione; Paradione; Paramethadionum; Paramethadionum [INN-Latin]; UNII-Z615FRW64N; A 348.

IUPAC/Chemical Name: 5-ethyl-3,5-dimethyloxazolidine-2,4-dione


InChi Code: InChI=1S/C7H11NO3/c1-4-7(2)5(9)8(3)6(10)11-7/h4H2,1-3H3

SMILES Code: C1([C@@](OC(=O)N1C)(CC)C)=O

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Schulman J. Epileptic seizures controlled with paramethadione/primidone. Vet Med Small Anim Clin. 1981 Jun;76(6):827. PubMed PMID: 6911910.

2: Lumholtz IB. [Drug information. Therapeutic main group: anti-epileptics - anticonvulsants. Succinimides (ethosuximide and phensuximide), oxazolidines (trimethadione and paramethadione), sulfonamide groups (acetazolamide and sulthiame)]. Sygeplejersken. 1977 Feb 23;77(8):11. Danish. PubMed PMID: 584547.

3: Hoffman DJ, Chun AH. Paramethadione and metabolite serum levels in humans after a single oral paramethadione dose. J Pharm Sci. 1975 Oct;64(10):1702-3. PubMed PMID: 1185541.

4: German J, Ehlers KH, Kowal A, De George FV, Engle MA, Passarge E. Possible teratogenicity of trimethadione and paramethadione. Lancet. 1970 Aug 1;2(7666):261-2. PubMed PMID: 4193708.

5: Heymann W. Nephrotic syndrome after use of trimethadione and paramethadione in petit mal. JAMA. 1967 Nov 27;202(9):893-4. PubMed PMID: 4964568.

6: BERGSTRAND A, BERGSTRAND CG, ENGSTROM N, HERRLIN KM. Renal histology during treatment with oxazolidine-diones (trimethadione, ethadione, and paramethadione). Pediatrics. 1962 Oct;30:601-7. PubMed PMID: 13970793.

7: BUTLER TC, WADDELL WJ. A pharmacological comparison of the optical isomers of 5-ethyl-5-methyl-2,4-oxazolidinedione and of 3,5-dimethyl-5 ethyl-2,4-oxazolidinedione (paramethadione, paradione). J Pharmacol Exp Ther. 1955 Feb;113(2):238-40. PubMed PMID: 13234047.

8: BUTLER TC. Metabolic demethylation of 3,5-dimethyl-5-ethyl 2,4-oxazolidinedione (paramethadione, paradione). J Pharmacol Exp Ther. 1955 Feb;113(2):178-85. PubMed PMID: 13234040.

9: WREN JC, NUTT RL. Nephrotic syndrome occurring during paramethadione therapy; report of a case with clinical remission. J Am Med Assoc. 1953 Nov 7;153(10):918-20. PubMed PMID: 13096309.

10: REICHELDERFER TE, PEARSON PH, LIVINGSTON S. Thrombocytopenic purpura occurring in association with paradione (paramethadione) and dilantin sodium (phenytoin sodium) therapy. J Pediatr. 1953 Jul;43(1):43-6. PubMed PMID: 13062072.

11: NEW and nonofficial remedies: paramethadione, paradione. J Am Med Assoc. 1950 Jul 15;143(11):970. PubMed PMID: 15421880.