UK 1

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526518

CAS#: 151271-53-3

Description: UK 1 is a cytotoxic metabolite from Streptomyces sp. 517-02.

Chemical Structure

UK 1
CAS# 151271-53-3

Theoretical Analysis

MedKoo Cat#: 526518
Name: UK 1
CAS#: 151271-53-3
Chemical Formula: C22H14N2O5
Exact Mass: 386.0903
Molecular Weight: 386.363
Elemental Analysis: C, 68.39; H, 3.65; N, 7.25; O, 20.70

Price and Availability

Size Price Availability Quantity
1.0mg USD 405.0 2 Weeks
Bulk inquiry

Synonym: UK 1, UK-1, UK1

IUPAC/Chemical Name: methyl 2'-(2-hydroxyphenyl)-[2,4'-bibenzo[d]oxazole]-4-carboxylate


InChi Code: InChI=1S/C22H14N2O5/c1-27-22(26)14-8-5-11-17-19(14)24-21(29-17)13-7-4-10-16-18(13)23-20(28-16)12-6-2-3-9-15(12)25/h2-11,25H,1H3


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 386.363 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

1: Glover AG, Wiklund H, Rabone M, Amon DJ, Smith CR, O'Hara T, Mah CL, Dahlgren TG. Abyssal fauna of the UK-1 polymetallic nodule exploration claim, Clarion-Clipperton Zone, central Pacific Ocean: Echinodermata. Biodivers Data J. 2016 Jan 25;(4):e7251. doi: 10.3897/BDJ.4.e7251. eCollection 2016. PubMed PMID: 26929713; PubMed Central PMCID: PMC4759440.

2: ESMRMB 2015, 32nd Annual Scientific Meeting, Edinburgh, UK, 1-3 October: Author Index. MAGMA. 2015 Oct;28 Suppl 1:521-36. doi: 10.1007/s10334-015-0491-6. PubMed PMID: 26407576.

3: ESMRMB 2015, 32nd Annual Scientific Meeting, Edinburgh, UK, 1-3 October: Abstracts, Saturday. MAGMA. 2015 Oct;28 Suppl 1:277-418. doi: 10.1007/s10334-015-0489-0. PubMed PMID: 26407574.

4: ESMRMB 2015, 32nd Annual Scientific Meeting, Edinburgh, UK, 1-3 October: Abstracts, Thursday. MAGMA. 2015 Oct;28 Suppl 1:1-135. doi: 10.1007/s10334-015-0487-2. PubMed PMID: 26407572.

5: ESMRMB 2015, 32nd Annual Scientific Meeting, Edinburgh, UK, 1-3 October: EPOS™ Poster / Paper Poster / Clinical Review Poster / Software Exhibits. MAGMA. 2015 Oct;28 Suppl 1:419-519. doi: 10.1007/s10334-015-0490-7. PubMed PMID: 26407575.

6: ESMRMB 2015, 32nd Annual Scientific Meeting, Edinburgh, UK, 1-3 October: Abstracts, Friday. MAGMA. 2015 Oct;28 Suppl 1:137-276. doi: 10.1007/s10334-015-0488-1. PubMed PMID: 26407573.

7: Shaw L. The Madness of Bedlam: A Time Team Special, Channel 4 [UK], 1 December 2013, 9 pm GMT. Med Hist. 2014 Apr;58(2):311-3. doi: 10.1017/mdh.2014.16. Review. PubMed PMID: 24775439; PubMed Central PMCID: PMC4006151.

8: Ward DN, Talley DC, Tavag M, Menji S, Schaughency P, Baier A, Smith PJ. UK-1 and structural analogs are potent inhibitors of hepatitis C virus replication. Bioorg Med Chem Lett. 2014 Jan 15;24(2):609-12. doi: 10.1016/j.bmcl.2013.12.012. Epub 2013 Dec 9. PubMed PMID: 24360997.

9: Miller CB, Pierlé SA, Brayton KA, Ochoa JN, Shah DH, Lahmers KK. Transcriptional Profiling of a Cross-Protective Salmonella enterica serovar Typhimurium UK-1 dam Mutant Identifies a Set of Genes More Transcriptionally Active Compared to Wild-Type, and Stably Transcribed across Biologically Relevant Microenvironments. Pathogens. 2014;3(2):417-436. PubMed PMID: 25364573; PubMed Central PMCID: PMC4213855.

10: Kanavos P, Angelis A. Acquiring Pharmaceutical Industry Assets in the UK: 1 + 1 = 1? Pharmaceut Med. 2014;28(5):245-248. PubMed PMID: 25346596; PubMed Central PMCID: PMC4203995.

11: Eom JS, Kim JS, Jang JI, Kim HG, Bang IS, Park YK. Effect of iacP mutation on flagellar phase variation in Salmonella enterica serovar typhimurium strain UK-1. J Bacteriol. 2012 Aug;194(16):4332-41. doi: 10.1128/JB.00076-12. Epub 2012 Jun 8. PubMed PMID: 22685287; PubMed Central PMCID: PMC3416257.

12: Luo Y, Kong Q, Yang J, Mitra A, Golden G, Wanda SY, Roland KL, Jensen RV, Ernst PB, Curtiss R 3rd. Comparative genome analysis of the high pathogenicity Salmonella Typhimurium strain UK-1. PLoS One. 2012;7(7):e40645. doi: 10.1371/journal.pone.0040645. Epub 2012 Jul 6. PubMed PMID: 22792393; PubMed Central PMCID: PMC3391293.

13: Luo Y, Kong Q, Yang J, Golden G, Wanda SY, Jensen RV, Ernst PB, Curtiss R 3rd. Complete genome sequence of the universal killer Salmonella enterica Serovar Typhimurium UK-1 (ATCC 68169). J Bacteriol. 2011 Aug;193(15):4035-6. doi: 10.1128/JB.05224-11. Epub 2011 May 27. PubMed PMID: 21622747; PubMed Central PMCID: PMC3147501.

14: Howarth JL, Lee YB, Uney JB. Using viral vectors as gene transfer tools (Cell Biology and Toxicology Special Issue: ETCS-UK 1 day meeting on genetic manipulation of cells). Cell Biol Toxicol. 2010 Feb;26(1):1-20. doi: 10.1007/s10565-009-9139-5. Epub 2009 Oct 15. PubMed PMID: 19830583; PubMed Central PMCID: PMC2817806.

15: Kumar D, Jacob MR, Reynolds MB, Kerwin SM. Synthesis and evaluation of anticancer benzoxazoles and benzimidazoles related to UK-1. Bioorg Med Chem. 2002 Dec;10(12):3997-4004. PubMed PMID: 12413851.

16: Burger D. Cell contact interactions in rheumatology, The Kennedy Institute for Rheumatology, London, UK, 1-2 June 2000. Arthritis Res. 2000;2(6):472-6. PubMed PMID: 11219394; PubMed Central PMCID: PMC128876.

17: Ueki M, Shibata K, Taniguchi M. UK-1, a novel cytotoxic metabolite from Streptomyces sp. 517-02. IV. Antifungal action of methyl UK-1. J Antibiot (Tokyo). 1998 Sep;51(9):883-5. PubMed PMID: 9820240.

18: Jones DR, Bui TH. Fetal therapy: prospects for transplantation early in pregnancy. In utero stem cell transplantation and gene therapy: second international meeting, Nottingham, UK, 1-2 September 1997. Mol Med Today. 1998 Jan;4(1):10-1. PubMed PMID: 9494961.

19: Shibata K, Kashiwada M, Ueki M, Taniguchi M. UK-1, a novel cytotoxic metabolite from Streptomyces sp. 517-02. II. Structural elucidation. J Antibiot (Tokyo). 1993 Jul;46(7):1095-100. PubMed PMID: 8360105.

20: Abstracts of papers presented at the 9th annual meeting of the United Kingdom Environmental Mutagen Society. Portsmouth, Hampshire, UK, 1-3 April 1985. Mutagenesis. 1986 Jan;1(1):67-79. PubMed PMID: 3325737.

UK 1

1.0mg / USD 405.0