WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 526563
Description: Way 100289 is a selective 5-HT3 receptor antagonist.
MedKoo Cat#: 526563
Name: Way 100289
Chemical Formula: C20H27N3O3
Exact Mass: 357.2052
Molecular Weight: 357.454
Elemental Analysis: C, 67.20; H, 7.61; N, 11.76; O, 13.43
This product is not in stock, which may be available by custom synthesis.
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Synonym: Way 100289; Way-100289; Way100289
IUPAC/Chemical Name: 2-(cyclopropylmethoxy)-N-((8-methyl-8-azabicyclo[3.2.1]octan-3-yl)carbamoyl)benzamide
InChi Key: VFRIHPWRNNTKEX-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H27N3O3/c1-23-15-8-9-16(23)11-14(10-15)21-20(25)22-19(24)17-4-2-3-5-18(17)26-12-13-6-7-13/h2-5,13-16H,6-12H2,1H3,(H2,21,22,24,25)
SMILES Code: O=C(NC(NC1CC(N2C)CCC2C1)=O)C3=CC=CC=C3OCC4CC4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 357.454 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Rodgers RJ, Cole JC, Tredwell JM. Profile of action of 5-HT3 receptor antagonists, ondansetron and WAY 100289, in the elevated plus-maze test of anxiety of mice. Psychopharmacology (Berl). 1995 Feb;117(3):306-12. PubMed PMID: 7770606.
2: Hodges H, Sowinski P, Sinden JD, Netto CA, Fletcher A. The selective 5-HT3 receptor antagonist, WAY100289, enhances spatial memory in rats with ibotenate lesions of the forebrain cholinergic projection system. Psychopharmacology (Berl). 1995 Feb;117(3):318-32. PubMed PMID: 7770608.
3: Bill DJ, Fletcher A, Glenn BD, Knight M. Behavioural studies on WAY100289, a novel 5-HT3 receptor antagonist, in two animal models of anxiety. Eur J Pharmacol. 1992 Aug 6;218(2-3):327-34. PubMed PMID: 1358637.