Verofylline

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526553

CAS#: 66172-75-6

Description: Verofylline is a methylxanthine bronchodilator.


Price and Availability

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Verofylline is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 526553
Name: Verofylline
CAS#: 66172-75-6
Chemical Formula: C12H18N4O2
Exact Mass: 250.143
Molecular Weight: 250.302
Elemental Analysis: C, 57.58; H, 7.25; N, 22.38; O, 12.78


Synonym: CK 0383; CK0383; CK-0383; Verofylline; Verofilina; Verofyllinum

IUPAC/Chemical Name: 1,8-dimethyl-3-(2-methylbutyl)-3,7-dihydro-1H-purine-2,6-dione

InChi Key: MTBUJUHRXVGLEF-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H18N4O2/c1-5-7(2)6-16-10-9(13-8(3)14-10)11(17)15(4)12(16)18/h7H,5-6H2,1-4H3,(H,13,14)

SMILES Code: O=C(N1C)N(CC(C)CC)C2=C(NC(C)=N2)C1=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Young RC Jr, Lucas SG, Morris EA, Pittman J, Rachal RE, Malveaux FJ, Booker WM. Verofylline, a methylxanthine bronchodilator, in asthma. Clin Pharmacol Ther. 1984 Dec;36(6):811-6. PubMed PMID: 6388955.

2: Shum L, Jusko WJ. Verofylline pharmacokinetics in dietary-induced obese rats: role of fat mass and protein binding in determining volume of distribution. Xenobiotica. 1991 Nov;21(11):1419-30. PubMed PMID: 1763516.

3: Shum L, Jusko WJ. Reversed-phase high-performance liquid chromatographic determination of verofylline in rat serum. J Chromatogr. 1986 Oct 31;382:207-13. PubMed PMID: 3782387.

4: Grassi C, Casali L, Rampulla C, Rossi A. Clinical efficacy trial: theophylline vs (dl) 3,7-dihydro-1,8-dimethyl-3-(2-methylbutyl)-1H-purine-2,6-dione. Int J Clin Pharmacol Ther Toxicol. 1980 Dec;18(12):518-22. PubMed PMID: 7014478.

5: Grassi C, Casali L, Rampulla C, Rossi A. Effect of (dl) 3,7-dihydro-1,8-dimethyl-3-(2-methylbutyl)-1H-purine-2,6-dione on exercise-induced bronchospasm. Int J Clin Pharmacol Ther Toxicol. 1981 Jul;19(7):297-302. PubMed PMID: 7263107.

6: Cho YW, Han HC, OH SY, Maines JE 3rd, Kuemmerle HP. A double-blind, placebo-controlled evaluation of (dl)-3,7-dihydro-1,8-dimethyl-3-(2-methylbutyl)-1H-purine-2,6-dione in exercise-induced bronchospasm. Int J Clin Pharmacol Ther Toxicol. 1981 Jun;19(6):266-72. PubMed PMID: 7030974.