GSK269962
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526665

CAS#: 850664-21-0 (free base)

Description: GSK269962 is a selective ROCK inhibitor with IC50 values of 1.6 and 6 nM for ROCK-I and ROCK-II, respectively. GSK269962 can become an alternative worth considering in OAB treatment.


Price and Availability

Size
Price

5mg
USD 90
50mg
USD 450
500mg
USD 2650
Size
Price

10mg
USD 150
100mg
USD 850
1g
USD 3450
Size
Price

25mg
USD 250
200mg
USD 1530
2g
USD 5250

GSK269962, purity > 98%, is in stock. The same day shipping out after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 526665
Name: GSK269962
CAS#: 850664-21-0 (free base)
Chemical Formula: C29H30N8O5
Exact Mass: 570.2339
Molecular Weight: 570.61
Elemental Analysis: C, 61.04; H, 5.30; N, 19.64; O, 14.02


Related CAS #: 925213-80-5 (3HCl)   850664-21-0 (free base)   2095432-71-4 (HCl)    

Synonym: GSK269962; GSK 269962; GSK-269962; GSK269962A; GSK 269962A; GSK-269962A; GSK269962B.

IUPAC/Chemical Name: N-[3-[[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy]phenyl]-4-[2-(4-morpholinyl)ethoxy]-benzamide

InChi Key: YOVNFNXUCOWYSG-UHFFFAOYSA-N

InChi Code: InChI=1S/C29H30N8O5/c1-2-37-24-17-25(31-18-23(24)33-28(37)26-27(30)35-42-34-26)41-22-5-3-4-20(16-22)32-29(38)19-6-8-21(9-7-19)40-15-12-36-10-13-39-14-11-36/h3-9,16-18H,2,10-15H2,1H3,(H2,30,35)(H,32,38)

SMILES Code: O=C(NC1=CC=CC(OC2=CC3=C(N=C(C4=NON=C4N)N3CC)C=N2)=C1)C5=CC=C(OCCN6CCOCC6)C=C5


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934990300


References

1: Wróbel A, Rechberger T. The Influence of Maxacalcitol, Vitamin D(3) Analog, on
Detrusor Overactivity in Conscious Rats. Urology. 2016 Mar 23. pii:
S0090-4295(16)00296-X. doi: 10.1016/j.urology.2016.03.008. [Epub ahead of print]
PubMed PMID: 27018369.

2: Wróbel A, Rechberger T. Ovariectomy May Induce Detrusor Overactivity in Rats:
the Therapeutic Role of Rho Kinase Inhibition. Urology. 2016 Mar 14. pii:
S0090-4295(16)00295-8. doi: 10.1016/j.urology.2016.03.007. [Epub ahead of print]
PubMed PMID: 26988893.

3: Wróbel A, Rechberger T. The effect of combined treatment with a β(3) AR
agonist and a ROCK inhibitor on detrusor overactivity. Neurourol Urodyn. 2016 Feb
16. doi: 10.1002/nau.22978. [Epub ahead of print] PubMed PMID: 26879338.

4: Wróbel A, Rechberger T. The influence of Rho-kinase inhibition on acetic
acid-induced detrusor overactivity. Neurourol Urodyn. 2015 Nov 6. doi:
10.1002/nau.22918. [Epub ahead of print] PubMed PMID: 26546786.

5: Hutchinson JL, Rajagopal SP, Yuan M, Norman JE. Lipopolysaccharide promotes
contraction of uterine myocytes via activation of Rho/ROCK signaling pathways.
FASEB J. 2014 Jan;28(1):94-105. doi: 10.1096/fj.13-237040. Epub 2013 Sep 27.
PubMed PMID: 24076962.