Candoxatrilat

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MedKoo CAT#: 524548

CAS#: 123122-54-3

Description: Candoxatrilat, also known as U 73967 and UK69578, is an active neutral endopeptidase inhibitor that reduces degradation of atrial natriuretic peptide. Candoxatrilat reduces the clearance of atrial natriuretic factor in both intact and nephrectomized rats: evidence for an extrarenal site of action.

Chemical Structure

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Candoxatrilat
CAS# 123122-54-3
Instruction

Theoretical Analysis

MedKoo Cat#: 524548
Name: Candoxatrilat
CAS#: 123122-54-3
Chemical Formula: C20H33NO7
Exact Mass: 399.23
Molecular Weight: 399.480
Elemental Analysis: C, 60.13; H, 8.33; N, 3.51; O, 28.04

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: U 73967; U-73967; U73967; UK69578; UK-69578; UK 69578; Candoxatrilate; Candoxatrilat.

IUPAC/Chemical Name: (1R,4s)-4-(1-((S)-2-carboxy-3-(2-methoxyethoxy)propyl)cyclopentanecarboxamido)cyclohexanecarboxylic acid

InChi Key: ACZWIDANLCXHBM-HRCADAONSA-N

InChi Code: InChI=1S/C20H33NO7/c1-27-10-11-28-13-15(18(24)25)12-20(8-2-3-9-20)19(26)21-16-6-4-14(5-7-16)17(22)23/h14-16H,2-13H2,1H3,(H,21,26)(H,22,23)(H,24,25)/t14-,15-,16+/m0/s1

SMILES Code: COCCOC[C@@H](C(=O)O)CC1(CCCC1)C(=O)N[C@H]2CC[C@H](CC2)C(=O)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 399.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Kaye B, Brearley CJ, Cussans NJ, Herron M, Humphrey MJ, Mollatt AR. Formation and pharmacokinetics of the active drug candoxatrilat in mouse, rat, rabbit, dog and man following administration of the prodrug candoxatril. Xenobiotica. 1997 Oct;27(10):1091-102. PubMed PMID: 9364744.

2: Barclay PL, Bennett JA, Greengrass PM, Griffin A, Samuels GM, Shepperson NB. The pharmacokinetics of 125I-atrial natriuretic factor in anaesthetized rats. Effects of neutral endopeptidase inhibition with candoxatrilat and of ANF-C receptor blockade. Biochem Pharmacol. 1992 Sep 25;44(6):1013-22. PubMed PMID: 1417928.

3: Barclay PL, Bennett JA, Samuels GM, Shepperson NB. The atriopeptidase inhibitor (+/-) candoxatrilat reduces the clearance of atrial natriuretic factor in both intact and nephrectomized rats: evidence for an extrarenal site of action. Biochem Pharmacol. 1991 Mar 1;41(5):841-4. PubMed PMID: 1847819.