WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 524380
Description: BAY-36-7620 is a selective mGlu1 receptor non-competitive antagonist with inverse agonist activity. It impairs classical conditioning and associated synaptic plasticity in hippocampal neurons. BAY-36-7620 exhibits neuroprotective and anticonvulsive effects in vivo following systemic administration.
MedKoo Cat#: 524380
Chemical Formula: C19H18O2
Exact Mass: 278.13068
Molecular Weight: 278.35
Elemental Analysis: C, 81.99; H, 6.52; O, 11.50
This product is not in stock, which may be available by custom synthesis.
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Synonym: BAY-36-7620; BAY 36-7620; BAY367620; UNII-0P934RSF8B;
IUPAC/Chemical Name: 1H-Cyclopenta(C)furan-1-one, hexahydro-5-methylene-6a-(2-naphthalenylmethyl)-, (3aS,6aS)-
InChi Key: CVIRWLJKDBYYOG-MJGOQNOKSA-N
InChi Code: InChI=1S/C19H18O2/c1-13-8-17-12-21-18(20)19(17,10-13)11-14-6-7-15-4-2-3-5-16(15)9-14/h2-7,9,17H,1,8,10-12H2/t17-,19+/m1/s1
SMILES Code: C=C1C[C@@H]2COC(=O)[C@@]2(C1)Cc3ccc4ccccc4c3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 278.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Sullivan KG, Levin M. Neurotransmitter signaling pathways required for normal
development in Xenopus laevis embryos: a pharmacological survey screen. J Anat. 2016 Apr 7. doi: 10.1111/joa.12467. [Epub ahead of print] PubMed PMID: 27060969.
2: Shim HG, Jang SS, Jang DC, Jin Y, Chang W, Park JM, Kim SJ. mGlu1 receptor mediates homeostatic control of intrinsic excitability through Ih in cerebellar Purkinje cells. J Neurophysiol. 2016 Feb 24:jn.00566.2015. doi: 10.1152/jn.00566.2015. [Epub ahead of print] PubMed PMID: 26912592.
3: Le MN, Chan JL, Rosenberg SA, Nabatian AS, Merrigan KT, Cohen-Solal KA, Goydos JS. The glutamate release inhibitor Riluzole decreases migration, invasion, and proliferation of melanoma cells. J Invest Dermatol. 2010 Sep;130(9):2240-9. doi:
10.1038/jid.2010.126. Epub 2010 May 27. PubMed PMID: 20505744; PubMed Central PMCID: PMC4004181.
4: Shin JH, Kim YS, Worley PF, Linden DJ. Depolarization-induced slow current in
cerebellar Purkinje cells does not require metabotropic glutamate receptor 1. Neuroscience. 2009 Sep 1;162(3):688-93. doi: 10.1016/j.neuroscience.2009.01.044.
Epub 2009 Jan 29. PubMed PMID: 19409231; PubMed Central PMCID: PMC2716407.
5: Schröder UH, Müller T, Schreiber R, Stolle A, Zuschratter W, Balschun D, Jork
R, Reymann KG. The potent non-competitive mGlu1 receptor antagonist BAY 36-7620 differentially affects synaptic plasticity in area cornu ammonis 1 of rat hippocampal slices and impairs acquisition in the water maze task in mice. Neuroscience. 2008 Nov 19;157(2):385-95. doi: 10.1016/j.neuroscience.2008.08.063. Epub 2008 Sep 9. PubMed PMID: 18832015.
6: Lavreysen H, Pereira SN, Leysen JE, Langlois X, Lesage AS. Metabotropic glutamate 1 receptor distribution and occupancy in the rat brain: a quantitative
autoradiographic study using [3H]R214127. Neuropharmacology. 2004 Apr;46(5):609-19. PubMed PMID: 14996538.
7: Lavreysen H, Janssen C, Bischoff F, Langlois X, Leysen JE, Lesage AS. [3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists. Mol Pharmacol. 2003 May;63(5):1082-93. PubMed PMID: 12695537.
8: De Vry J, Horváth E, Schreiber R. Neuroprotective and behavioral effects of the selective metabotropic glutamate mGlu(1) receptor antagonist BAY 36-7620. Eur J Pharmacol. 2001 Oct 5;428(2):203-14. PubMed PMID: 11675037.
9: Bruno V, Battaglia G, Copani A, D'Onofrio M, Di Iorio P, De Blasi A, Melchiorri D, Flor PJ, Nicoletti F. Metabotropic glutamate receptor subtypes as targets for neuroprotective drugs. J Cereb Blood Flow Metab. 2001 Sep;21(9):1013-33. Review. PubMed PMID: 11524608.