BAY-36-7620

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 524380

CAS#: 232605-26-4

Description: BAY-36-7620 is a selective mGlu1 receptor non-competitive antagonist with inverse agonist activity. It impairs classical conditioning and associated synaptic plasticity in hippocampal neurons. BAY-36-7620 exhibits neuroprotective and anticonvulsive effects in vivo following systemic administration.

Chemical Structure

img
BAY-36-7620
CAS# 232605-26-4
Instruction

Theoretical Analysis

MedKoo Cat#: 524380
Name: BAY-36-7620
CAS#: 232605-26-4
Chemical Formula: C19H18O2
Exact Mass: 278.13
Molecular Weight: 278.350
Elemental Analysis: C, 81.99; H, 6.52; O, 11.50

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: BAY-36-7620; BAY 36-7620; BAY367620; UNII-0P934RSF8B;

IUPAC/Chemical Name: 1H-Cyclopenta(C)furan-1-one, hexahydro-5-methylene-6a-(2-naphthalenylmethyl)-, (3aS,6aS)-

InChi Key: CVIRWLJKDBYYOG-MJGOQNOKSA-N

InChi Code: InChI=1S/C19H18O2/c1-13-8-17-12-21-18(20)19(17,10-13)11-14-6-7-15-4-2-3-5-16(15)9-14/h2-7,9,17H,1,8,10-12H2/t17-,19+/m1/s1

SMILES Code: C=C1C[C@@H]2COC(=O)[C@@]2(C1)Cc3ccc4ccccc4c3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 278.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Sullivan KG, Levin M. Neurotransmitter signaling pathways required for normal

development in Xenopus laevis embryos: a pharmacological survey screen. J Anat. 2016 Apr 7. doi: 10.1111/joa.12467. [Epub ahead of print] PubMed PMID: 27060969.

2: Shim HG, Jang SS, Jang DC, Jin Y, Chang W, Park JM, Kim SJ. mGlu1 receptor mediates homeostatic control of intrinsic excitability through Ih in cerebellar Purkinje cells. J Neurophysiol. 2016 Feb 24:jn.00566.2015. doi: 10.1152/jn.00566.2015. [Epub ahead of print] PubMed PMID: 26912592.

3: Le MN, Chan JL, Rosenberg SA, Nabatian AS, Merrigan KT, Cohen-Solal KA, Goydos JS. The glutamate release inhibitor Riluzole decreases migration, invasion, and proliferation of melanoma cells. J Invest Dermatol. 2010 Sep;130(9):2240-9. doi:

10.1038/jid.2010.126. Epub 2010 May 27. PubMed PMID: 20505744; PubMed Central PMCID: PMC4004181.

4: Shin JH, Kim YS, Worley PF, Linden DJ. Depolarization-induced slow current in

cerebellar Purkinje cells does not require metabotropic glutamate receptor 1. Neuroscience. 2009 Sep 1;162(3):688-93. doi: 10.1016/j.neuroscience.2009.01.044.

Epub 2009 Jan 29. PubMed PMID: 19409231; PubMed Central PMCID: PMC2716407.

5: Schröder UH, Müller T, Schreiber R, Stolle A, Zuschratter W, Balschun D, Jork

R, Reymann KG. The potent non-competitive mGlu1 receptor antagonist BAY 36-7620 differentially affects synaptic plasticity in area cornu ammonis 1 of rat hippocampal slices and impairs acquisition in the water maze task in mice. Neuroscience. 2008 Nov 19;157(2):385-95. doi: 10.1016/j.neuroscience.2008.08.063. Epub 2008 Sep 9. PubMed PMID: 18832015.

6: Lavreysen H, Pereira SN, Leysen JE, Langlois X, Lesage AS. Metabotropic glutamate 1 receptor distribution and occupancy in the rat brain: a quantitative

autoradiographic study using [3H]R214127. Neuropharmacology. 2004 Apr;46(5):609-19. PubMed PMID: 14996538.

7: Lavreysen H, Janssen C, Bischoff F, Langlois X, Leysen JE, Lesage AS. [3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists. Mol Pharmacol. 2003 May;63(5):1082-93. PubMed PMID: 12695537.

8: De Vry J, Horváth E, Schreiber R. Neuroprotective and behavioral effects of the selective metabotropic glutamate mGlu(1) receptor antagonist BAY 36-7620. Eur J Pharmacol. 2001 Oct 5;428(2):203-14. PubMed PMID: 11675037.

9: Bruno V, Battaglia G, Copani A, D'Onofrio M, Di Iorio P, De Blasi A, Melchiorri D, Flor PJ, Nicoletti F. Metabotropic glutamate receptor subtypes as targets for neuroprotective drugs. J Cereb Blood Flow Metab. 2001 Sep;21(9):1013-33. Review. PubMed PMID: 11524608.