BAL30072

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 524365

CAS#: 941285-15-0

Description: BAL30072 is a monocyclic β-lactam belonging to the monosulfactam class used for the treatment of infections caused by Gram-negative bacteria. BAL30072 carries a dihydroxypyridone moiety in its oxyiminoacyl side chain that may allow it to exploit iron-uptake systems to gain accelerated entry into bacteria. BAL30072 has previously been shown to have strong antimicrobial activity against most aerobic Gram-negative bacilli.

Chemical Structure

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BAL30072
CAS# 941285-15-0
Instruction

Theoretical Analysis

MedKoo Cat#: 524365
Name: BAL30072
CAS#: 941285-15-0
Chemical Formula: C16H18N6O10S2
Exact Mass: 518.05
Molecular Weight: 518.480
Elemental Analysis: C, 37.06; H, 3.50; N, 16.21; O, 30.86; S, 12.37

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: BAL30072; BAL 30072; BAL-30072;

IUPAC/Chemical Name: 4-Thiazoleacetamide, 2-amino-alpha-(((1,4-dihydro-1,5-dihydroxy-4-oxo-2-pyridinyl)methoxy)imino)-N-((3S)-2,2-dimethyl-4-oxo-1-(Sulfooxy)-3-azetidinyl)-, (alphaz)-

InChi Key: KLFSEZJCLYBFKQ-WXYNYTDUSA-N

InChi Code: InChI=1S/C16H18N6O10S2/c1-16(2)12(14(26)22(16)32-34(28,29)30)19-13(25)11(8-6-33-15(17)18-8)20-31-5-7-3-9(23)10(24)4-21(7)27/h3-4,6,12,24,27H,5H2,1-2H3,(H2,17,18)(H,19,25)(H,28,29,30)/b20-11-/t12-/m1/s1

SMILES Code: O=C(N[C@H]1C(C)(C)N(OS(=O)(O)=O)C1=O)/C(C2=CSC(N)=N2)=N\OCC3=CC(C(O)=CN3O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 518.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Straubinger M, Blenk H, Naber KG, Wagenlehner FM. Urinary Concentrations and Antibacterial Activity of BAL30072, a Novel Siderophore Monosulfactam, against Uropathogens after Intravenous Administration in Healthy Subjects. Antimicrob Agents Chemother. 2016 Mar 14. pii: AAC.02425-15. [Epub ahead of print] PubMed PMID: 26976871.

2: Fu HG, Hu XX, Li CR, Li YH, Wang YX, Jiang JD, Bi CW, Tang S, You XF, Song DQ. Design, synthesis and biological evaluation of monobactams as antibacterial agents against gram-negative bacteria. Eur J Med Chem. 2016 Mar 3;110:151-63. doi: 10.1016/j.ejmech.2016.01.024. Epub 2016 Jan 20. PubMed PMID: 26827160.

3: Wang YT, Cheng TL. Refined models of New Delhi metallo-beta-lactamase-1 with inhibitors: an QM/MM modeling study. J Biomol Struct Dyn. 2016 Jan 6:1-10. [Epub ahead of print] PubMed PMID: 26488313.

4: Hornsey M, Phee L, Stubbings W, Wareham DW. In vitro activity of the novel monosulfactam BAL30072 alone and in combination with meropenem versus a diverse collection of important Gram-negative pathogens. Int J Antimicrob Agents. 2013 Oct;42(4):343-6. doi: 10.1016/j.ijantimicag.2013.05.010. Epub 2013 Jul 7. PubMed PMID: 23837926.

5: Landman D, Singh M, El-Imad B, Miller E, Win T, Quale J. In vitro activity of the siderophore monosulfactam BAL30072 against contemporary Gram-negative pathogens from New York City, including multidrug-resistant isolates. Int J Antimicrob Agents. 2014 Jun;43(6):527-32. doi: 10.1016/j.ijantimicag.2014.02.017. Epub 2014 Apr 13. PubMed PMID: 24796217.

6: Mushtaq S, Woodford N, Hope R, Adkin R, Livermore DM. Activity of BAL30072 alone or combined with β-lactamase inhibitors or with meropenem against carbapenem-resistant Enterobacteriaceae and non-fermenters. J Antimicrob Chemother. 2013 Jul;68(7):1601-8. doi: 10.1093/jac/dkt050. Epub 2013 Feb 28. PubMed PMID: 23449829.