WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526622

CAS#: 1443118-44-2

Description: ML337 is a highly selective mGlu3 NAMs with submicromolar potency and good CNS penetration. ML337 resulted (mGlu3 IC50 = 593 nM, mGlu2 IC50 >30 μM) with B:P ratios of 0.92 (mouse) to 0.3 (rat). ML337 possesses favorable physiochemical properties, a good dystrophia myotonica protein kinase (DMPK) profile and is centrally penetrant. Thus, ML337 is a best-in-class in vitro and in vivo probe for studying non-competitive antagonism of mGlu3.

Chemical Structure

CAS# 1443118-44-2

Theoretical Analysis

MedKoo Cat#: 526622
Name: ML337
CAS#: 1443118-44-2
Chemical Formula: C21H20FNO3
Exact Mass: 353.14
Molecular Weight: 353.393
Elemental Analysis: C, 71.37; H, 5.70; F, 5.38; N, 3.96; O, 13.58

Price and Availability

Size Price Availability Quantity
25mg USD 450 2 Weeks
50mg USD 750 2 Weeks
100mg USD 1350 2 Weeks
200mg USD 2150 2 Weeks
500mg USD 3250 2 Weeks
1g USD 4650 2 Weeks
2g USD 7450 2 Weeks
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Synonym: ML-337; ML 337; ML337.

IUPAC/Chemical Name: (R)-(2-fluoro-4-((4-methoxyphenyl)ethynyl)phenyl)(3-hydroxypiperidin-1-yl)methanone


InChi Code: InChI=1S/C21H20FNO3/c1-26-18-9-6-15(7-10-18)4-5-16-8-11-19(20(22)13-16)21(25)23-12-2-3-17(24)14-23/h6-11,13,17,24H,2-3,12,14H2,1H3/t17-/m1/s1


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 353.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Wenthur C, Daniels JS, Morrison R, Engers JL, Niswender CM, Conn PJ, Lindsley
CW. Development of a Second Generation mGlu(3) NAM Probe. 2012 Dec 10 [updated
2013 Mar 22]. Probe Reports from the NIH Molecular Libraries Program [Internet].
Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
Available from
PubMed PMID: 23885366.

2: Wenthur CJ, Morrison R, Felts AS, Smith KA, Engers JL, Byers FW, Daniels JS,
Emmitte KA, Conn PJ, Lindsley CW. Discovery of
(3-hydroxypiperidin-1-yl)methanone (ML337), an mGlu3 selective and CNS penetrant
negative allosteric modulator (NAM). J Med Chem. 2013 Jun 27;56(12):5208-12. doi:
10.1021/jm400439t. Epub 2013 Jun 13. PubMed PMID: 23718281; PubMed Central PMCID: