D-64131
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407421

CAS#: 74588-78-6

Description: D-64131 is a potent and selective tubulin inhibitor. D-64131 inhibits tumor cell proliferation in vitro (IC50 = 74 nM). In xenograft experiments with the human amelanoic melanoma MEXF 989, D-64131 was highly active with treatment resulting in a growth delay of 23.4 days at 400 mg/kg.


Chemical Structure

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D-64131
CAS# 74588-78-6

Theoretical Analysis

MedKoo Cat#: 407421
Name: D-64131
CAS#: 74588-78-6
Chemical Formula: C16H13NO2
Exact Mass: 251.0946
Molecular Weight: 251.285
Elemental Analysis: C, 76.48; H, 5.21; N, 5.57; O, 12.73

Price and Availability

Size Price Availability Quantity
25.0mg USD 190.0 2 Weeks
50.0mg USD 350.0 2 Weeks
100.0mg USD 550.0 2 Weeks
200.0mg USD 850.0 2 Weeks
500.0mg USD 1650.0 2 Weeks
1.0g USD 2450.0 2 Weeks
2.0g USD 4250.0 2 Weeks
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Synonym: D-64131; D 64131; D64131.

IUPAC/Chemical Name: (5-Methoxy-1H-indol-2-yl)phenylmeth​anone

InChi Key: ICMIJSRDISNKOC-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H13NO2/c1-19-13-7-8-14-12(9-13)10-15(17-14)16(18)11-5-3-2-4-6-11/h2-10,17H,1H3

SMILES Code: O=C(C(N1)=CC2=C1C=CC(OC)=C2)C3=CC=CC=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 251.285 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Putey A, Popowycz F, Do QT, Bernard P, Talapatra SK, Kozielski F, Galmarini
CM, Joseph B. Indolobenzazepin-7-ones and 6-, 8-, and 9-membered ring derivatives
as tubulin polymerization inhibitors: synthesis and structure--activity
relationship studies. J Med Chem. 2009 Oct 8;52(19):5916-25. doi:
10.1021/jm900476c. PubMed PMID: 19743863.

2: Beckers T, Reissmann T, Schmidt M, Burger AM, Fiebig HH, Vanhoefer U, Pongratz
H, Hufsky H, Hockemeyer J, Frieser M, Mahboobi S. 2-aroylindoles, a novel class
of potent, orally active small molecule tubulin inhibitors. Cancer Res. 2002 Jun
1;62(11):3113-9. PubMed PMID: 12036922.

D-64131

25.0mg / USD 190.0