Proparacaine Hydrochloride
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MedKoo CAT#: 318585

CAS#: 5875-06-9

Description: Proparacaine Hydrochloride is the hydrochloride salt form of proparacaine, a benzoic acid derivative with local anesthetic property. It is used as a topical ophthalmic anesthetic. Proparacaine hydrochloride stabilizes the neuronal membrane by binding to and inhibiting voltage-gated sodium channels, thereby inhibiting sodium ion influx required for the initiation and conduction of impulses within the neuronal cell, and resulting in a loss of sensation.


Chemical Structure

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Proparacaine Hydrochloride
CAS# 5875-06-9

Theoretical Analysis

MedKoo Cat#: 318585
Name: Proparacaine Hydrochloride
CAS#: 5875-06-9
Chemical Formula: C16H27ClN2O3
Exact Mass: 0.00
Molecular Weight: 330.850
Elemental Analysis: C, 58.08; H, 8.23; Cl, 10.72; N, 8.47; O, 14.51

Price and Availability

Size Price Availability Quantity
5g USD -1
100mg USD 150
200mg USD 250
500mg USD 450
1g USD 650
2g USD 950
Bulk inquiry

Synonym: Proparacaine Hydrochloride; Proxymetacaine hydrochloride; Proparacaine Hcl; Ophthain; proxymetacaine monohydrochloride; UNII-U96OL57GOY; Minims; Proxymetacaine Hydrochloride; Ocu-Caine; Ophthaine; Ophthetic; Parcaine;

IUPAC/Chemical Name: 2-(diethylamino)ethyl 3-amino-4-propoxybenzoate;hydrochloride

InChi Key: BFUUJUGQJUTPAF-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H26N2O3.ClH/c1-4-10-20-15-8-7-13(12-14(15)17)16(19)21-11-9-18(5-2)6-3;/h7-8,12H,4-6,9-11,17H2,1-3H3;1H

SMILES Code: CCCOC1=C(C=C(C=C1)C(=O)OCCN(CC)CC)N.Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 330.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Joshi RS. A single drop of 0.5% proparacaine hydrochloride for uncomplicated
clear corneal phacoemulsification. Middle East Afr J Ophthalmol. 2013
Jul-Sep;20(3):221-4. doi: 10.4103/0974-9233.114795. PubMed PMID: 24014985; PubMed
Central PMCID: PMC3757631.


2: Joshi RS. Proparacaine hydrochloride topical drop and intracameral 0.5%
lignocaine for phacotrabeculectomy in patients with primary open angle glaucoma.
Middle East Afr J Ophthalmol. 2014 Jul-Sep;21(3):210-5. doi:
10.4103/0974-9233.134669. PubMed PMID: 25100903; PubMed Central PMCID:
PMC4123271.


3: Pucket JD, Allbaugh RA, Rankin AJ, Ou Z, Bello NM. Comparison of efficacy and
duration of effect on corneal sensitivity among anesthetic agents following
ocular administration in clinically normal horses. Am J Vet Res. 2013
Mar;74(3):459-64. doi: 10.2460/ajvr.74.3.459. PubMed PMID: 23438124.


4: Murphy PJ, Ntola AM. Prolonged corneal anaesthesia by proxymetacaine
hydrochloride detected by a thermal cooling stimulus. Cont Lens Anterior Eye.
2009 Apr;32(2):84-7; quiz 99-100. doi: 10.1016/j.clae.2008.12.006. Epub 2009 Jan
31. PubMed PMID: 19181566.


5: Zhang J, Yang M, Zhou M, He L, Chen N, Zakrzewska JM. Non-antiepileptic drugs
for trigeminal neuralgia. Cochrane Database Syst Rev. 2013 Dec 3;12:CD004029.
doi: 10.1002/14651858.CD004029.pub4. Review. PubMed PMID: 24297506.


6: Kalf KL, Utter ME, Wotman KL. Evaluation of duration of corneal anesthesia
induced with ophthalmic 0.5% proparacaine hydrochloride by use of a Cochet-Bonnet
aesthesiometer in clinically normal horses. Am J Vet Res. 2008 Dec;69(12):1655-8.
doi: 10.2460/ajvr.69.12.1655. PubMed PMID: 19046014.


7: Binder DR, Herring IP. Duration of corneal anesthesia following topical
administration of 0.5% proparacaine hydrochloride solution in clinically normal
cats. Am J Vet Res. 2006 Oct;67(10):1780-2. PubMed PMID: 17014333.


8: Herring IP, Bobofchak MA, Landry MP, Ward DL. Duration of effect and effect of
multiple doses of topical ophthalmic 0.5% proparacaine hydrochloride in
clinically normal dogs. Am J Vet Res. 2005 Jan;66(1):77-80. PubMed PMID:
15691039.


9: Cydulka RK, Betzelos S. Seizures following the use of proparacaine
hydrochloride eye drops. J Emerg Med. 1990 Mar-Apr;8(2):131-3. PubMed PMID:
2362113.


10: Brent MH, Slomovic AR, Easterbrook M. Keratitis associated with the use of
proparacaine hydrochloride. CMAJ. 1987 Feb 15;136(4):380-1. PubMed PMID: 3815202;
PubMed Central PMCID: PMC1492048.


11: TANTON JH. FLUORESCEIN-PROPARACAINE HYDROCHLORIDE. COMBINATION DROPS FOR
APPLANATION TONOMETRY. Am J Ophthalmol. 1964 Dec;58:1055-6. PubMed PMID:
14233708.


12: PROPARACAINE hydrochloride. J Am Med Assoc. 1958 Aug 16;167(16):1936-7.
PubMed PMID: 13563203.


13: Wang XM, Ma LX, Wang LH. [Research of cyclopentolate 1% on the effect of
cycloplegia for Chinese hyperopic children]. Zhonghua Yan Ke Za Zhi. 2011
Nov;47(11):989-94. Chinese. PubMed PMID: 22336064.


14: Dass BA, Soong HK, Lee B. Effects of proparacaine on actin cytoskeleton of
corneal epithelium. J Ocul Pharmacol. 1988 Fall;4(3):187-94. PubMed PMID:
3198982.


15: Liesegang TJ, Perniciaro C. Fingertip dermatitis in an ophthalmologist caused
by proparacaine. Am J Ophthalmol. 1999 Feb;127(2):240-1. PubMed PMID: 10030585.


16: Ward B, McCulley JP, Segal RJ. Dermatologic reaction in Stevens-Johnson
syndrome after ophthalmic anesthesia with proparacaine hydrochloride. Am J
Ophthalmol. 1978 Jul;86(1):133-5. PubMed PMID: 354393.


17: Kim SK, Hong JP, Nam SM, Stulting RD, Seo KY. Analgesic effect of
preoperative topical nonsteroidal antiinflammatory drugs on postoperative pain
after laser-assisted subepithelial keratectomy. J Cataract Refract Surg. 2015
Apr;41(4):749-55. doi: 10.1016/j.jcrs.2014.06.041. PubMed PMID: 25840299.


18: Şimşek A, Bilak Ş, Güler M, Çapkin M, Bilgin B, Reyhan AH. Comparison of
Central Corneal Thickness Measurements Obtained by RTVue OCT, Lenstar, Sirius
Topography, and Ultrasound Pachymetry in Healthy Subjects. Semin Ophthalmol. 2015
Aug 21:1-6. [Epub ahead of print] PubMed PMID: 25412328.


19: Tok OY, Tok L, Atay IM, Argun TC, Demirci N, Gunes A. Toxic keratopathy
associated with abuse of topical anesthetics and amniotic membrane
transplantation for treatment. Int J Ophthalmol. 2015 Oct 18;8(5):938-44. doi:
10.3980/j.issn.2222-3959.2015.05.15. eCollection 2015. PubMed PMID: 26558205;
PubMed Central PMCID: PMC4631004.


20: Deka S, Bhattacharjee H, Barman MJ, Kalita K, Singh SK. No-patch 23-gauge
vitrectomy under topical anesthesia: a pilot study. Indian J Ophthalmol. 2011
Mar-Apr;59(2):143-5. doi: 10.4103/0301-4738.77038. PubMed PMID: 21350284; PubMed
Central PMCID: PMC3116543.