WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 523114
CAS#: 66170-10-3
Description: VOK 70103, also known as 2-Phospho-L-ascorbic acid trisodium salt is a stable ascorbic acid derivative used in cell culture. In combination with FGF-2, it maintains differentiation potential in bone marrow-derived mesenchymal stem cells (MSC) through increased expression of HGF. L-Ascorbic acid 2-phosphate may be used in cell differentiation and tissue engineering applications. 2-Phospho-L-ascorbic acid trisodium salt also exhibits synergistic protection of hMSCs under oxidative stress in combination with N-acetylcysteine. Asc-2P is used in studies of gene repression, such as the repression of dihydrotestosterone-induced dickkopf-1 expression. AA2P has been shown to increase myogenin gene expression and promote differentiation in L6 muscle cells. This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).
MedKoo Cat#: 523114
Name: VOK 70103
CAS#: 66170-10-3
Chemical Formula: C6H6Na3O9P
Exact Mass: 321.94425
Molecular Weight: 322.05
Elemental Analysis: C, 22.38; H, 1.88; Na, 21.42; O, 44.71; P, 9.62
Synonym: 2-Phospho-L-ascorbic acid trisodium salt; 523114; VOK 70103; VOK-70103; VOK70103
IUPAC/Chemical Name: sodium (R)-5-((S)-1,2-dihydroxyethyl)-2-oxido-4-oxo-4,5-dihydrofuran-3-yl phosphate
InChi Key: VWCFDYSMDMCPLU-OFBPEYICSA-K
InChi Code: InChI=1S/C6H9O9P.3Na/c7-1-2(8)4-3(9)5(6(10)14-4)15-16(11,12)13;;;/h2,4,7-8,10H,1H2,(H2,11,12,13);;;/q;3*+1/p-3/t2-,4+;;;/m0.../s1
SMILES Code: O=C(C(OP([O-])([O-])=O)=C([O-])O1)[C@H]1[C@@H](O)CO.[Na+].[Na+].[Na+]
Appearance: Solid powder
Purity: >95% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 322.05 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Alvarado-Gámez AL, Alonso-Lomillo MA, Domínguez-Renedo O, Arcos-Martínez MJ. A chronoamperometric screen printed carbon biosensor based on alkaline phosphatase inhibition for W(IV) determination in water, using 2-phospho-L-ascorbic acid trisodium salt as a substrate. Sensors (Basel). 2015 Jan 22;15(2):2232-43. doi: 10.3390/s150202232. PubMed PMID: 25621602; PubMed Central PMCID: PMC4367303.
2: Huang CH, Sung HC, Hsiao CY, Hu S, Ko YS. Transdermal delivery of three vitamin C derivatives by Er:YAG and carbon dioxide laser pretreatment. Lasers Med Sci. 2013 May;28(3):807-14. doi: 10.1007/s10103-012-1151-y. Epub 2012 Jul 24. PubMed PMID: 22825318.
