Paroxetine Hydrochloride
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MedKoo CAT#: 318458

CAS#: 78246-49-8 (HCl)

Description: Paroxetine hydrochloride is a serotonin uptake inhibitor that is effective in the treatment of depression. It is a highly potent and selective ST (serotonin transporter/5-HT) uptake inhibitor. It acts by binding to ST (serotonin transporter/SERT) with high affinity. Paroxetine binds to the pre-synaptic serotonin transporter complex resulting in negative allosteric modulation of the complex thereby blocking reuptake of serotonin by the pre-synaptic transporter. Paroxetine HCl has also displayed a high affinity for muscarinic acetylcholine receptors.


Price and Availability

Size Price Shipping out time Quantity
25mg USD 250 2 Weeks
50mg USD 450 2 Weeks
100mg USD 650 2 Weeks
200mg USD 950 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-07-12. Prices are subject to change without notice.

Paroxetine Hydrochloride, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 318458
Name: Paroxetine Hydrochloride
CAS#: 78246-49-8 (HCl)
Chemical Formula: C19H21ClFNO3
Exact Mass:
Molecular Weight: 365.83
Elemental Analysis: C, 62.38; H, 5.79; Cl, 9.69; F, 5.19; N, 3.83; O, 13.12


Related CAS #: 61869-08-7 (free base)   64006-44-6 (maleate)   78246-49-8 (HCl)   72471-80-8 (acetate)   217797-14-3 (mesylate)  

Synonym: Paroxetine Hydrochloride; Paroxetine Hcl; Paroxat; Aropax 20; (3S,4R)-3-((Benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine hydrochloride; Paxil; Seroxat;

IUPAC/Chemical Name: (3S,4R)-3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine;hydrochloride

InChi Key: GELRVIPPMNMYGS-RVXRQPKJSA-N

InChi Code: InChI=1S/C19H20FNO3.ClH/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18;/h1-6,9,14,17,21H,7-8,10-12H2;1H/t14-,17-;/m0./s1

SMILES Code: C1CNCC(C1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4.Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

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evaluation of in vitro, in vivo properties of novel controlled release
compositions of paroxetine hydrochloride hemihydrate as against Geomatrix™
platform technology. Drug Dev Ind Pharm. 2013 Aug;39(8):1175-86. doi:
10.3109/03639045.2012.682222. Epub 2012 May 21. PubMed PMID: 22607046.

2: Germann D, Ma G, Han F, Tikhomirova A. Paroxetine hydrochloride. Profiles Drug
Subst Excip Relat Methodol. 2013;38:367-406. doi:
10.1016/B978-0-12-407691-4.00008-3. Review. PubMed PMID: 23668408.

3: Brittain HG. Paroxetine hydrochloride: polymorphs and solvatomorphs. Profiles
Drug Subst Excip Relat Methodol. 2013;38:407-21. doi:
10.1016/B978-0-12-407691-4.00009-5. Review. PubMed PMID: 23668409.

4: Pae CU, Misra A, Ham BJ, Han C, Patkar AA, Masand PS. Paroxetine mesylate:
comparable to paroxetine hydrochloride? Expert Opin Pharmacother. 2010
Feb;11(2):185-93. doi: 10.1517/14656560903451708. Review. PubMed PMID: 20088740.

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controlled release POLYOX matrix tablets: screening of formulation variables
using Plackett-Burman screening design. Arch Pharm Res. 2008 Mar;31(3):399-405.
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of the antidepressant drug paroxetine hydrochloride in tablets. J AOAC Int. 2005
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tension-type headache not responding to amitriptyline hydrochloride with
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PubMed PMID: 14511278; PubMed Central PMCID: PMC2128053.

8: Sugi K, Itaya N, Katsura T, Igi M, Yamazaki S, Ishibashi T, Yamaoka T, Kawada
Y, Tagami Y, Otsuki M, Ohshima T. Improved synthesis of paroxetine hydrochloride
propan-2-ol solvate through one of metabolites in humans, and characterization of
the solvate crystals. Chem Pharm Bull (Tokyo). 2000 Apr;48(4):529-36. PubMed
PMID: 10783073.

9: Ibers JA. Paroxetine hydrochloride hemihydrate. Acta Crystallogr C. 1999 Mar
15;55 ( Pt 3):432-4. PubMed PMID: 10220873.

10: Frisolone JA, Ruiz M, Schwartz BJ. Criteria for use of paroxetine
hydrochloride in adult inpatients and outpatients. American Society of Hospital
Pharmacists. Am J Hosp Pharm. 1994 Mar 15;51(6):827-8. PubMed PMID: 8010326.

11: Venkatachalam A, Chatterjee VS. Stability-indicating high performance thin
layer chromatography determination of Paroxetine hydrochloride in bulk drug and
pharmaceutical formulations. Anal Chim Acta. 2007 Aug 29;598(2):312-7. Epub 2007
Aug 8. PubMed PMID: 17719907.

12: Alarfaj N, Razeq SA, Sultan M. Spectrofluorimetric determination of
paroxetine hydrochloride in its formulations and human plasma. Chem Pharm Bull
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13: Roscoe JA, Morrow GR, Hickok JT, Mustian KM, Griggs JJ, Matteson SE, Bushunow
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depression in breast cancer patients receiving chemotherapy. Breast Cancer Res
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14609280.

15: Motofei IG. Re: Treatment of premature ejaculation with paroxetine
hydrochloride as needed: 2 single-blind placebo controlled crossover studies. J
Urol. 2002 Oct;168(4 Pt 1):1508-9. PubMed PMID: 12352444.

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hydrochloride as needed: 2 single-blind placebo controlled crossover studies. J
Urol. 2001 Dec;166(6):2325. PubMed PMID: 11696776.

17: Stearns V, Isaacs C, Rowland J, Crawford J, Ellis MJ, Kramer R, Lawrence W,
Hanfelt JJ, Hayes DF. A pilot trial assessing the efficacy of paroxetine
hydrochloride (Paxil) in controlling hot flashes in breast cancer survivors. Ann
Oncol. 2000 Jan;11(1):17-22. PubMed PMID: 10690382.

18: McMahon CG, Touma K. Treatment of premature ejaculation with paroxetine
hydrochloride. Int J Impot Res. 1999 Oct;11(5):241-245; discussion 246. PubMed
PMID: 10553802.

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hydrochloride as needed: 2 single-blind placebo controlled crossover studies. J
Urol. 1999 Jun;161(6):1826-30. PubMed PMID: 10332446.

20: Di Girolamo E, Di Iorio C, Sabatini P, Leonzio L, Barbone C, Barsotti A.
Effects of paroxetine hydrochloride, a selective serotonin reuptake inhibitor, on
refractory vasovagal syncope: a randomized, double-blind, placebo-controlled
study. J Am Coll Cardiol. 1999 Apr;33(5):1227-30. PubMed PMID: 10193720.