Paroxetine Hydrochloride

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MedKoo CAT#: 318458

CAS#: 78246-49-8 (HCl)

Description: Paroxetine hydrochloride is a serotonin uptake inhibitor that is effective in the treatment of depression. It is a highly potent and selective ST (serotonin transporter/5-HT) uptake inhibitor. It acts by binding to ST (serotonin transporter/SERT) with high affinity. Paroxetine binds to the pre-synaptic serotonin transporter complex resulting in negative allosteric modulation of the complex thereby blocking reuptake of serotonin by the pre-synaptic transporter. Paroxetine HCl has also displayed a high affinity for muscarinic acetylcholine receptors.

Price and Availability

Size Price Shipping out time Quantity
25mg USD 250 2 Weeks
50mg USD 450 2 Weeks
100mg USD 650 2 Weeks
200mg USD 950 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-07-12. Prices are subject to change without notice.

Paroxetine Hydrochloride, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 318458
Name: Paroxetine Hydrochloride
CAS#: 78246-49-8 (HCl)
Chemical Formula: C19H21ClFNO3
Exact Mass:
Molecular Weight: 365.83
Elemental Analysis: C, 62.38; H, 5.79; Cl, 9.69; F, 5.19; N, 3.83; O, 13.12

Related CAS #: 61869-08-7 (free base)   64006-44-6 (maleate)   78246-49-8 (HCl)   72471-80-8 (acetate)   217797-14-3 (mesylate)  

Synonym: Paroxetine Hydrochloride; Paroxetine Hcl; Paroxat; Aropax 20; (3S,4R)-3-((Benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine hydrochloride; Paxil; Seroxat;

IUPAC/Chemical Name: (3S,4R)-3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine;hydrochloride


InChi Code: InChI=1S/C19H20FNO3.ClH/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18;/h1-6,9,14,17,21H,7-8,10-12H2;1H/t14-,17-;/m0./s1


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Khatavkar UN, Shimpi SL, Jayaram Kumar K, Deo KD. Development and comparative
evaluation of in vitro, in vivo properties of novel controlled release
compositions of paroxetine hydrochloride hemihydrate as against Geomatrix™
platform technology. Drug Dev Ind Pharm. 2013 Aug;39(8):1175-86. doi:
10.3109/03639045.2012.682222. Epub 2012 May 21. PubMed PMID: 22607046.

2: Germann D, Ma G, Han F, Tikhomirova A. Paroxetine hydrochloride. Profiles Drug
Subst Excip Relat Methodol. 2013;38:367-406. doi:
10.1016/B978-0-12-407691-4.00008-3. Review. PubMed PMID: 23668408.

3: Brittain HG. Paroxetine hydrochloride: polymorphs and solvatomorphs. Profiles
Drug Subst Excip Relat Methodol. 2013;38:407-21. doi:
10.1016/B978-0-12-407691-4.00009-5. Review. PubMed PMID: 23668409.

4: Pae CU, Misra A, Ham BJ, Han C, Patkar AA, Masand PS. Paroxetine mesylate:
comparable to paroxetine hydrochloride? Expert Opin Pharmacother. 2010
Feb;11(2):185-93. doi: 10.1517/14656560903451708. Review. PubMed PMID: 20088740.

5: Jin SJ, Yoo YH, Kim MS, Kim JS, Park JS, Hwang SJ. Paroxetine hydrochloride
controlled release POLYOX matrix tablets: screening of formulation variables
using Plackett-Burman screening design. Arch Pharm Res. 2008 Mar;31(3):399-405.
doi: 10.1007/s12272-001-1170-0. Epub 2008 Apr 13. PubMed PMID: 18409056.

6: Onal A, Kepekçi SE, Oztunç A. Spectrophotometric methods for the determination
of the antidepressant drug paroxetine hydrochloride in tablets. J AOAC Int. 2005
Mar-Apr;88(2):490-5. PubMed PMID: 15859076.

7: Holroyd KA, Labus JS, O'Donnell FJ, Cordingley GE. Treating chronic
tension-type headache not responding to amitriptyline hydrochloride with
paroxetine hydrochloride: a pilot evaluation. Headache. 2003 Oct;43(9):999-1004.
PubMed PMID: 14511278; PubMed Central PMCID: PMC2128053.

8: Sugi K, Itaya N, Katsura T, Igi M, Yamazaki S, Ishibashi T, Yamaoka T, Kawada
Y, Tagami Y, Otsuki M, Ohshima T. Improved synthesis of paroxetine hydrochloride
propan-2-ol solvate through one of metabolites in humans, and characterization of
the solvate crystals. Chem Pharm Bull (Tokyo). 2000 Apr;48(4):529-36. PubMed
PMID: 10783073.

9: Ibers JA. Paroxetine hydrochloride hemihydrate. Acta Crystallogr C. 1999 Mar
15;55 ( Pt 3):432-4. PubMed PMID: 10220873.

10: Frisolone JA, Ruiz M, Schwartz BJ. Criteria for use of paroxetine
hydrochloride in adult inpatients and outpatients. American Society of Hospital
Pharmacists. Am J Hosp Pharm. 1994 Mar 15;51(6):827-8. PubMed PMID: 8010326.

11: Venkatachalam A, Chatterjee VS. Stability-indicating high performance thin
layer chromatography determination of Paroxetine hydrochloride in bulk drug and
pharmaceutical formulations. Anal Chim Acta. 2007 Aug 29;598(2):312-7. Epub 2007
Aug 8. PubMed PMID: 17719907.

12: Alarfaj N, Razeq SA, Sultan M. Spectrofluorimetric determination of
paroxetine hydrochloride in its formulations and human plasma. Chem Pharm Bull
(Tokyo). 2006 Apr;54(4):564-6. PubMed PMID: 16595967.

13: Roscoe JA, Morrow GR, Hickok JT, Mustian KM, Griggs JJ, Matteson SE, Bushunow
P, Qazi R, Smith B. Effect of paroxetine hydrochloride (Paxil) on fatigue and
depression in breast cancer patients receiving chemotherapy. Breast Cancer Res
Treat. 2005 Feb;89(3):243-9. PubMed PMID: 15754122.

14: Erk N, Biryol I. Voltammetric and HPLC techniques for the determination of
paroxetine hydrochloride. Pharmazie. 2003 Oct;58(10):699-704. PubMed PMID:

15: Motofei IG. Re: Treatment of premature ejaculation with paroxetine
hydrochloride as needed: 2 single-blind placebo controlled crossover studies. J
Urol. 2002 Oct;168(4 Pt 1):1508-9. PubMed PMID: 12352444.

16: Balachandra K. Re: Treatment of premature ejaculation with paroxetine
hydrochloride as needed: 2 single-blind placebo controlled crossover studies. J
Urol. 2001 Dec;166(6):2325. PubMed PMID: 11696776.

17: Stearns V, Isaacs C, Rowland J, Crawford J, Ellis MJ, Kramer R, Lawrence W,
Hanfelt JJ, Hayes DF. A pilot trial assessing the efficacy of paroxetine
hydrochloride (Paxil) in controlling hot flashes in breast cancer survivors. Ann
Oncol. 2000 Jan;11(1):17-22. PubMed PMID: 10690382.

18: McMahon CG, Touma K. Treatment of premature ejaculation with paroxetine
hydrochloride. Int J Impot Res. 1999 Oct;11(5):241-245; discussion 246. PubMed
PMID: 10553802.

19: McMahon CG, Touma K. Treatment of premature ejaculation with paroxetine
hydrochloride as needed: 2 single-blind placebo controlled crossover studies. J
Urol. 1999 Jun;161(6):1826-30. PubMed PMID: 10332446.

20: Di Girolamo E, Di Iorio C, Sabatini P, Leonzio L, Barbone C, Barsotti A.
Effects of paroxetine hydrochloride, a selective serotonin reuptake inhibitor, on
refractory vasovagal syncope: a randomized, double-blind, placebo-controlled
study. J Am Coll Cardiol. 1999 Apr;33(5):1227-30. PubMed PMID: 10193720.