Paramethasone Acetate
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MedKoo CAT#: 318454

CAS#: 1597-82-6

Description: Paramethasone Acetate is a fluorinated glucocorticoid with anti-inflammatory and immunosuppressant properties.


Price and Availability

Size Price Shipping out time Quantity
5mg USD 350 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-07-10. Prices are subject to change without notice.

Paramethasone Acetate, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 318454
Name: Paramethasone Acetate
CAS#: 1597-82-6
Chemical Formula: C24H31FO6
Exact Mass:
Molecular Weight: 434.5
Elemental Analysis: C, 66.34; H, 7.19; F, 4.37; O, 22.09


Synonym: Paramethasone Acetate; UNII-8X50N88ZDP; Monocortin; 8X50N88ZDP; CHEBI:31963; NCGC00185748-01; Haldrone (TN);

IUPAC/Chemical Name: 16-alpha-Methyl-6-alpha-fluoro-prednisolone-21-acetate

InChi Key: HYRKAAMZBDSJFJ-WMCOPNSBSA-N

InChi Code: InChI=1S/C24H31FO6/c1-12-7-16-15-9-18(25)17-8-14(27)5-6-22(17,3)21(15)19(28)10-23(16,4)24(12,30)20(29)11-31-13(2)26/h5-6,8,12,15-16,18-19,21,28,30H,7,9-11H2,1-4H3/t12-,15+,16+,18+,19?,21-,22+,23+,24+/m1/s1

SMILES Code: CC1CC2C3CC(C4=CC(=O)C=CC4(C3C(CC2(C1(C(=O)COC(=O)C)O)C)O)C)F


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Cortés-Gallegos V, Alonso R, Castañeda G, Sojo I, Carranco A, Cervantes C,
Parra A. Paramethasone acetate (PA): corticosteroid potency vs hypothalamic
pituitary-gonadal axis. J Steroid Biochem. 1984 Jan;20(1):353-6. PubMed PMID:
6423900.

2: Cortés-Gallegos V, Carranco A, Sojo I, Alonso R, Valenzuela-Duriet P. Effect
of paramethasone acetate upon estrogen action. Fertil Steril. 1982
Mar;37(3):402-5. PubMed PMID: 7060790.

3: Cortés-Gallegos V, Gallegos AJ, Tovar NB, Cervantes C, Parra A. Effect of
paramethasone acetate on ovarian steroids and gonadotropins. I. Normal menstrual
cycle. J Clin Endocrinol Metab. 1975 Aug;41(2):215-20. PubMed PMID: 1159039.

4: Menarini C, Lanzarini AM. [Clinical study of injectable paramethasone acetate:
comparative study on the therapeutic effect of
6-alpha-fluoro-16-alpha-methyl-prednisolone-21-acetate administered orally and
parenterally]. Clin Ter. 1971 Dec 31;59(6):499-505. Italian. PubMed PMID:
5143383.

5: de Figueiredo OP. [Therapeutic action of syntex paramethasone acetate in
intra-articular and intrabursal infiltrations]. Hospital (Rio J). 1970
Nov-Dec;78(5):1367-72. Portuguese. PubMed PMID: 5314886.

6: Rausch-Stroomann JG, Petry R. [Mode of action of intramuscularly administered
depot-steroids studied using the example of paramethasone acetate].
Arzneimittelforschung. 1969 May;19(5):767-9. German. PubMed PMID: 5819786.

7: Jurmand SH, Manuel R, Normandin C, de Seze M. [Injectable paramethasone
acetate. Its place in loco-regional corticoid therapy in rheumatology]. Presse
Med. 1967 May 13;75(23):1185-6. French. PubMed PMID: 5297921.

8: Vinel P. [Clinical study on a new corticoid using intra-articular injections:
paramethasone acetate (75 treated cases)]. Rhumatologie. 1967 Apr;19(4):135-8.
French. PubMed PMID: 5620144.

9: Piccolo E, Agostini E, Rossi M. [Contribution on the use of paramethasone
acetate in cardiology]. Folia Cardiol. 1966 Jul-Aug;25(4):185-92. Italian. PubMed
PMID: 6013140.

10: Brunelli L, Gardoni L. [Paramethasone acetate and function of the
pituitary-adrenal axis in childhood]. Folia Endocrinol. 1966 Feb;19(1):125-30.
Italian. PubMed PMID: 5953699.

11: SCALABRINO R, CURTARELLI G. [OBSERVATIONS ON THE THERAPEUTIC USE OF
PARAMETHASONE ACETATE (6-ALPHA-FLUORO-16-ALPHA-METHYL-PREDNISOLONE), A NEW
SYNTHETIC CORTICOSTEROID]. Minerva Med. 1965 Jul 14;56:2419-25. Italian. PubMed
PMID: 14337873.

12: SHIATORIASHIRATORI A, NISHITANI M. [TREATMENT OF SKIN DISEASES WITH
PARAMETHASONE ACETATE (PARAMESONE)]. Hifuka Kiyo. 1964 Aug;59:225-30. Japanese.
PubMed PMID: 14211308.

13: POMMEY B, GUILLAUME J, AUFFRET M, ALBAHARY C. [EFFECTS AND HAZARDS OF A NEW
CORTICOID: PARAMETHASONE ACETATE]. Therapie. 1964 May-Jun;19:697-710. French.
PubMed PMID: 14182953.

14: GADRAT J, RIBET A. [TREATMENT OF 25 CASES OF ASCITIC CIRRHOSIS WITH
PARAMETHASONE ACETATE. CLINICAL AND BIOLOGICAL STUDY]. Toulouse Med. 1964
Feb;65:183-9. French. PubMed PMID: 14146591.

15: FURUKAWA W, TAKEUCHI T. [CLINICAL TRIAL OF PARAMETHASONE ACETATE IN
PEDIATRICS]. Chiryo. 1964;46:780-4. Japanese. PubMed PMID: 14148039.

16: FONTANA G, LADELLI G, GRECO V. [Clinical observations on the treatment of
rheumatic diseases with 6-alpha-fluoro-16-alpha-methylprednisolone (paramethasone
acetate)]. Minerva Med. 1963 May 5;54:1298-311. Italian. PubMed PMID: 13958642.

17: CHEN CH. [Paramethasone acetate in the treatment of the nephrotic syndrome in
children]. Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi. 1962 Jul-Sep;3:114-7.
Chinese. PubMed PMID: 14020489.

18: Miranda-Romero A, Bajo-del Pozo C, Sánchez-Sambucety P, Martinez-Fernandez M,
Garcia-Muñoz M. Delayed local allergic reaction to intralesional paramethasone
acetate. Contact Dermatitis. 1998 Jul;39(1):31-2. PubMed PMID: 9686977.

19: Fuentes, Vigaray. [Efficacy of an injectable preparation of paramethasone
acetate and phosphate in seasonal allergic rhinitis]. Allergol Immunopathol
(Madr). 1981 Mar-Apr;9(2):153-4. Spanish. PubMed PMID: 7293877.

20: Cortés-Gallegos V, Alonso-Uriarte ME, Said LE, Cervantes C, Parra A. Effect
of paramethasone acetate on women with secondary amenorrhea: a preliminary
report. Fertil Steril. 1978 Apr;29(4):402-6. PubMed PMID: 77230.