Pantoprazole Sodium
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MedKoo CAT#: 318452

CAS#: 138786-67-1

Description: Pantoprazole Sodium is a gastic proton pump inhibitor. It suppresses gastric acid secretion by blocking acid (proton) pump within gastric parietal cells.


Price and Availability

Size Price Shipping out time Quantity
1g USD 150 2 Weeks
2g USD 250 2 Weeks
5g USD 450 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-07-10. Prices are subject to change without notice.

Pantoprazole Sodium, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 318452
Name: Pantoprazole Sodium
CAS#: 138786-67-1
Chemical Formula: C16H14F2N3NaO4S
Exact Mass:
Molecular Weight: 405.35
Elemental Analysis: C, 47.41; H, 3.48; F, 9.37; N, 10.37; Na, 5.67; O, 15.79; S, 7.91


Synonym: Pantoprazole Sodium; Pantoloc; Controloc; Pantecta; Zurcal; Protonix; SK and F 96022; SK and F-96022; SKF-96022;

IUPAC/Chemical Name: sodium;5-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methylsulfinyl]benzimidazol-1-ide

InChi Key: YNWDKZIIWCEDEE-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H14F2N3O4S.Na/c1-23-13-5-6-19-12(14(13)24-2)8-26(22)16-20-10-4-3-9(25-15(17)18)7-11(10)21-16;/h3-7,15H,8H2,1-2H3;/q-1;+1

SMILES Code: COC1=C(C(=NC=C1)CS(=O)C2=NC3=C([N-]2)C=CC(=C3)OC(F)F)OC.[Na+]


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Ragab MT, Abd El-Rahman MK, Ramadan NK, El-Ragehy NA, El-Zeany BA. Novel
potentiometric application for the determination of pantoprazole sodium and
itopride hydrochloride in their pure and combined dosage form. Talanta. 2015 Jun
1;138:28-35. doi: 10.1016/j.talanta.2015.01.045. Epub 2015 Feb 9. PubMed PMID:
25863367.

2: Ramadan NK, El-Ragehy NA, Ragab MT, El-Zeany BA. Simultaneous determination of
a binary mixture of pantoprazole sodium and itopride hydrochloride by four
spectrophotometric methods. Spectrochim Acta A Mol Biomol Spectrosc. 2015 Feb
25;137:463-70. doi: 10.1016/j.saa.2014.09.003. Epub 2014 Sep 10. PubMed PMID:
25238185.

3: Biju PG, Gubrij I, Garg S, Gupta PK, Hauer-Jensen M, Burnett AF. Radiation
lethality potentiation in total body irradiated mice by a commonly prescribed
proton pump inhibitor, Pantoprazole sodium. Int J Radiat Biol. 2014
Jul;90(7):554-9. doi: 10.3109/09553002.2014.905727. PubMed PMID: 24646079; PubMed
Central PMCID: PMC4378842.

4: Naharcý MI, Cintosun U, Ozturk A, Bozoglu E, Doruk H. Pantoprazole
sodium-induced hyponatremia in a frail elderly adult. J Am Geriatr Soc. 2014
Apr;62(4):787-8. doi: 10.1111/jgs.12767. PubMed PMID: 24731036.

5: Bhatt NM, Chavada VD, Sanyal M, Shrivastav PS. Manipulating ratio spectra for
the spectrophotometric analysis of diclofenac sodium and pantoprazole sodium in
laboratory mixtures and tablet formulation. ScientificWorldJournal. 2014 Feb
18;2014:495739. doi: 10.1155/2014/495739. eCollection 2014. PubMed PMID:
24701171; PubMed Central PMCID: PMC3948650.

6: Kamdi SP, Palkar PJ. Bioequivalence Study of Pantoprazole Sodium-HPBCD and
Conventional Pantoprazole Sodium Enteric-Coated Tablet Formulations. ISRN
Pharmacol. 2013;2013:347457. doi: 10.1155/2013/347457. Epub 2013 Feb 7. PubMed
PMID: 23476803; PubMed Central PMCID: PMC3582054.

7: Dhurke R, Kushwaha I, Desai BG. Improvement in photostability of pantoprazole
sodium by microencapsulation. PDA J Pharm Sci Technol. 2013 Jan-Feb;67(1):43-52.
doi: 10.5731/pdajpst.2013.00901. PubMed PMID: 23385563.

8: Donnelly RF. Stability of pantoprazole sodium in glass vials, polyvinyl
chloride minibags, and polypropylene syringes. Can J Hosp Pharm. 2011
May;64(3):192-8. PubMed PMID: 22479054; PubMed Central PMCID: PMC3130754.

9: Mostafa HF, Ibrahim MA, Mahrous GM, Sakr A. Assessment of the pharmaceutical
quality of marketed enteric coated pantoprazole sodium sesquihydrate products.
Saudi Pharm J. 2011 Apr;19(2):123-7. doi: 10.1016/j.jsps.2011.01.001. Epub 2011
Jan 22. PubMed PMID: 23960750; PubMed Central PMCID: PMC3744956.

10: Hein J. Comparison of the efficacy and safety of pantoprazole magnesium and
pantoprazole sodium in the treatment of gastro-oesophageal reflux disease: a
randomized, double-blind, controlled, multicentre trial. Clin Drug Investig.
2011;31(9):655-64. doi: 10.2165/11590270-000000000-00000. PubMed PMID: 21819161.

11: Chen MM, Wang CR, Jin Y. [Preparation of pantoprazole sodium enteric-coated
pellets-type tablets]. Yao Xue Xue Bao. 2011 Jan;46(1):96-101. Chinese. PubMed
PMID: 21465814.

12: Gupta NV, Shivakumar HG. Preparation and characterization of superporous
hydrogels as pH-sensitive drug delivery system for Pantoprazole sodium. Curr Drug
Deliv. 2009 Oct;6(5):505-10. PubMed PMID: 19863492.

13: Shao JG, Jiang W, Li KQ, Lu JR, Sun YY. Blood concentration of pantoprazole
sodium is significantly high in hepatogenic peptic ulcer patients, especially
those with a poor CYP2C19 metabolism. J Dig Dis. 2009 Feb;10(1):55-60. doi:
10.1111/j.1751-2980.2008.00363.x. PubMed PMID: 19236548.

14: Ding G, Tang A, Wang J, Cong R, Bao J. [Direct enantioseparation of
pantoprazole sodium by high performance liquid chromatography on
teicoplanin-bonded chiral stationary phase]. Se Pu. 2006 Jan;24(1):46-8. Chinese.
PubMed PMID: 16827310.

15: Okazaki K, Mori S, Tahashi K. [Recent topics on important drugs for H. pylori
eradication: Pantoprazole sodium]. Nihon Rinsho. 2005 Nov;63 Suppl 11:354-60.
Review. Japanese. PubMed PMID: 16363559.

16: Ding G, Cong R, Wang J. [Direct enantiomeric separation of pantoprazole
sodium by high performance liquid chromatography]. Se Pu. 2004 May;22(3):241-3.
Chinese. PubMed PMID: 15712907.

17: Salama F, El-Abasawy N, Abdel Razeq SA, Ismail MM, Fouad MM. Validation of
the spectrophotometric determination of omeprazole and pantoprazole sodium via
their metal chelates. J Pharm Biomed Anal. 2003 Oct 15;33(3):411-21. PubMed PMID:
14550860.

18: Reddy GM, Bhaskar BV, Reddy PP, Ashok S, Sudhakar P, Babu JM, Vyas K,
Mukkanti K. Structural identification and characterization of potential
impurities of pantoprazole sodium. J Pharm Biomed Anal. 2007 Oct 18;45(2):201-10.
Epub 2007 Jun 2. PubMed PMID: 17629653.

19: El-Sherif ZA, Mohamed AO, El-Bardicy MG, El-Tarras MF. Reversed-phase high
performance liquid chromatographic method for the determination of lansoprazole,
omeprazole and pantoprazole sodium sesquihydrate in presence of their
Acid-induced degradation products. Chem Pharm Bull (Tokyo). 2006 Jun;54(6):814-8.
PubMed PMID: 16755049.

20: Zupancic V, Ograjsek N, Kotar-Jordan B, Vrecer F. Physical characterization
of pantoprazole sodium hydrates. Int J Pharm. 2005 Mar 3;291(1-2):59-68. Epub
2004 Dec 29. PubMed PMID: 15707732.