Faxeladol

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MedKoo CAT#: 319906

CAS#: 433265-65-7

Description: Faxeladol, also known as GCR9905, GRT-TA300, GRTA0009906, EM-906 and GRTA9906, is an opioid analgesic agent. Faxeladol is related to tramadol and ciramadol, and was developed shortly after tramadol in the late 1970s. Similarly to tramadol, it was believed faxeladol would have analgesic, as well as antidepressant effects, due to its action on serotonin and norepinephrine reuptake. In various studies in the 1970s alongside tramadol, faxeladol was seen to be slightly more potent than tramadol, but with a higher rate of sudden seizures than tramadol, which is known to cause seizures without warning in some users.

Chemical Structure

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Faxeladol
CAS# 433265-65-7
Instruction

Theoretical Analysis

MedKoo Cat#: 319906
Name: Faxeladol
CAS#: 433265-65-7
Chemical Formula: C15H23NO
Exact Mass: 233.18
Molecular Weight: 233.355
Elemental Analysis: C, 77.21; H, 9.94; N, 6.00; O, 6.86

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: GCR9905; GCR 9905; GCR-9905; EM-906; EM 906; EM906; GRT-TA300; GRTA9906; GRTA-9906; GRTA 9906; GRTA0009906; GRTA-0009906;GRTA 0009906;Faxeladol

IUPAC/Chemical Name: 3-((1R,2R)-2-((dimethylamino)methyl)cyclohexyl)phenol

InChi Key: JIRYWFYYBBRJAN-ZFWWWQNUSA-N

InChi Code: InChI=1S/C15H23NO/c1-16(2)11-13-6-3-4-9-15(13)12-7-5-8-14(17)10-12/h5,7-8,10,13,15,17H,3-4,6,9,11H2,1-2H3/t13-,15-/m0/s1

SMILES Code: OC1=CC=CC([C@H]2[C@H](CN(C)C)CCCC2)=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 233.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Sindrup SH, Konder R, Lehmann R, Meier T, Winkel M, Ashworth J, Baron R, Jensen TS. Randomized controlled trial of the combined monoaminergic and opioid investigational compound GRT9906 in painful polyneuropathy. Eur J Pain. 2012 Jul;16(6):849-59. doi: 10.1002/j.1532-2149.2011.00069.x. PubMed PMID: 22337471.