Bentamapimod
featured

We are open as normal during COVID-19 pandemic. Order online, same day shipping out from North Carolina, USA

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 319883

CAS#: 848344-36-5

Description: Bentamapimod, also known as AS602801 and PGL5001, is a JNK Inhibitor. AS602801 induces regression of endometriotic lesions in animal models. AS602801 interrupts immune pathways. Bentamapimod induced regression of endometriotic lesions in endometriosis rodent animal models without suppressing ER action. Endometriosis is an estrogen (ER)-dependent gynecological disease caused by the growth of endometrial tissue at extrauterine sites.


Price and Availability

Size Price Shipping out time Quantity
25mg USD 150 Same day
50mg USD 250 Same day
100mg USD 450 Same day
200mg USD 850 Same day
500mg USD 1650 Same day
1g USD 2950 Same day
2g USD 4650 2 weeks
5g USD 6950 2 weeks
Inquire bulk and customized quantity

Pricing updated 2020-08-09. Prices are subject to change without notice.

Bentamapimod, purity > 97%, is in stock.The same day shipping after order is received.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 319883
Name: Bentamapimod
CAS#: 848344-36-5
Chemical Formula: C25H23N5O2S
Exact Mass: 457.1572
Molecular Weight: 457.552
Elemental Analysis: C, 65.63; H, 5.07; N, 15.31; O, 6.99; S, 7.01


Synonym: AS602801; AS-602801; AS 602801; PGL5001; PGL-5001; PGL 5001; Bentamapimod

IUPAC/Chemical Name: 2-(1,3-benzothiazol-2-yl)-2-[2-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)pyrimidin-4-yl]acetonitrile

InChi Key: XCPPIJCBCWUBNT-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H23N5O2S/c26-15-20(24-28-22-3-1-2-4-23(22)33-24)21-9-10-27-25(29-21)32-17-19-7-5-18(6-8-19)16-30-11-13-31-14-12-30/h1-10,20H,11-14,16-17H2

SMILES Code: N#CC(C1=NC2=CC=CC=C2S1)C3=NC(OCC4=CC=C(CN5CCOCC5)C=C4)=NC=C3


Technical Data

Appearance:
Solid powder

Purity:
>97% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (SDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Hussein M, Chai DC, Kyama CM, Mwenda JM, Palmer SS, Gotteland JP, D'Hooghe TM.
c-Jun NH(2)-terminal kinase inhibitor bentamapimod reduces induced endometriosis
in baboons: an assessor-blind placebo-controlled randomized study. Fertil Steril.
2015 Dec 2. pii: S0015-0282(15)02106-8. doi: 10.1016/j.fertnstert.2015.11.022.
[Epub ahead of print] PubMed PMID: 26654972.

2: Palmer SS, Altan M, Denis D, Tos EG, Gotteland JP, Osteen KG, Bruner-Tran KL,
Nataraja SG. Bentamapimod (JNK Inhibitor AS602801) Induces Regression of
Endometriotic Lesions in Animal Models. Reprod Sci. 2016 Jan;23(1):11-23. doi:
10.1177/1933719115600553. Epub 2015 Sep 2. PubMed PMID: 26335175.