WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 319880

CAS#: 342577-38-2

Description: Velneperit, also known as S-2367, is potent and selective neuropeptide Y Y5-receptor antagonist under evaluating for treatment of obesity.

Chemical Structure

CAS# 342577-38-2

Theoretical Analysis

MedKoo Cat#: 319880
Name: Velneperit
CAS#: 342577-38-2
Chemical Formula: C17H24F3N3O3S
Exact Mass: 407.15
Molecular Weight: 407.450
Elemental Analysis: C, 50.11; H, 5.94; F, 13.99; N, 10.31; O, 11.78; S, 7.87

Price and Availability

Size Price Availability Quantity
10mg USD 450 2 Weeks
25g USD 750 2 Weeks
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Synonym: S-2367; S 2367; S2367; Velneperit

IUPAC/Chemical Name: (1r,4r)-4-((1,1-dimethylethyl)sulfonamido)-N-(5-(trifluoromethyl)pyridin-2-yl)cyclohexane-1-carboxamide


InChi Code: InChI=1S/C17H24F3N3O3S/c1-16(2,3)27(25,26)23-13-7-4-11(5-8-13)15(24)22-14-9-6-12(10-21-14)17(18,19)20/h6,9-11,13,23H,4-5,7-8H2,1-3H3,(H,21,22,24)/t11-,13-

SMILES Code: O=C([C@H]1CC[C@H](NS(=O)(C(C)(C)C)=O)CC1)NC2=NC=C(C(F)(F)F)C=C2

Appearance: White to off-white solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 407.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Bhat SP, Sharma A. Current Drug Targets in Obesity Pharmacotherapy - A Review. Curr Drug Targets. 2017 Feb 27. doi: 10.2174/1389450118666170227153940. [Epub ahead of print] PubMed PMID: 28245771.

2: George M, Rajaram M, Shanmugam E. New and emerging drug molecules against obesity. J Cardiovasc Pharmacol Ther. 2014 Jan;19(1):65-76. doi: 10.1177/1074248413501017. Epub 2013 Sep 24. Review. PubMed PMID: 24064009.