WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 319821
CAS#: 478941-80-9 (HCl)
Description: Budiodarone, also known as ATI-2042, is an antiarrhythmic agent and chemical analog of amiodarone. Budiodarone has a half life of 7 h. It is electrophysiologically similar to amiodarone, but may not have metabolic and interaction side effects. ATI-2042 effectively reduced AFB over all doses studied by reducing mean episode duration. Budiodarone holds much promise as an antiarrhythmic drug to prevent fibrillation. As a drug that spans over many of antiarrhythmic drug classes, the electrophysiological activity of budiodarone includes.
MedKoo Cat#: 319821
Name: Budiodarone HCl
CAS#: 478941-80-9 (HCl)
Chemical Formula: C27H32ClI2NO5
Exact Mass: 703.0292
Molecular Weight: 739.8139
Elemental Analysis: C, 43.83; H, 4.36; Cl, 4.79; I, 34.31; N, 1.89; O, 10.81
Related CAS #: 478941-80-9 (HCl) 478941-93-4 (tartrate) 335148-45-3 (free base) 478941-90-1 (maleate) 478941-86-5 (fumarate) 478941-98-9 (citrate)
Synonym: Budiodarone HCl; Budiodarone hydrochloride; (S)-ATI 2042; ATI-2042; ATI2042; ATI 2042; Budiodarone;
IUPAC/Chemical Name: (S)-sec-butyl 2-(3-(4-(2-(diethylamino)ethoxy)-3,5-diiodobenzoyl)benzofuran-2-yl)acetate hydrochloride
InChi Key: WDMVNERQUKWYOA-LMOVPXPDSA-N
InChi Code: InChI=1S/C27H31I2NO5.ClH/c1-5-17(4)34-24(31)16-23-25(19-10-8-9-11-22(19)35-23)26(32)18-14-20(28)27(21(29)15-18)33-13-12-30(6-2)7-3;/h8-11,14-15,17H,5-7,12-13,16H2,1-4H3;1H/t17-;/m0./s1
SMILES Code: O=C(O[C@@H](C)CC)CC1=C(C(C2=CC(I)=C(OCCN(CC)CC)C(I)=C2)=O)C3=CC=CC=C3O1.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
| Biological target: | Budiodarone, also known as ATI-2042, is an antiarrhythmic agent and chemical analog of amiodarone. |
| In vitro activity: | TBD |
| In vivo activity: | TBD |
The following data is based on the product molecular weight 739.8139 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | TBD |
| In vitro protocol: | TBD |
| In vivo protocol: | TBD |
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Amiodarone is considered the most effective antiarrhythmic drug available, but its adverse side effects, including hepatic, pulmonary and thyroid toxicity as well as multiple drug interactions,[4] are discouraging its use. Budiodarone only differs in structure from amiodarone through the presence of a sec-butyl acetate side chain at position 2 of the benzofuran moiety. This side chain allows for budiodarone to have a shorter half-life in the body than amiodarone (7 hours versus 35–68 days) which allows it to have a faster onset of action and metabolism while still maintaining similar electrophysiological activity. The faster metabolism of budiodarone allows for fewer adverse side effects than amiodarone principally due to decreased levels of toxicity in the body.
