Cerlapirdine
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MedKoo CAT#: 319728

CAS#: 925448-93-7 (free base)

Description: Cerlapirdine, also known as SAM-531, WAY-262,531 and PF-05212365, is a selective, potent, full antagonist of the 5-hydroxytryptamine 6 (5-HT6) receptor. Cerlapirdine has been in clinical development for the treatment of cognitive disorders associated with Alzheimer's disease and schizophrenia. As of 2011, it is in phase II clinical trials, and has demonstrated a trend toward efficacy along with a good side effect profile and no incidence of serious adverse events. It exerts its effects by acting as a selective 5-HT6 receptor antagonist.


Price and Availability

Size
Price

5mg
USD 190
Size
Price

10mg
USD 250
Size
Price

25mg
USD 450

Cerlapirdine purity > 98%, is in stock. The same day shipping out after order is received. Note: the estimated shipping out time for order > 200mg may be 2 weeks.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 319728
Name: Cerlapirdine
CAS#: 925448-93-7 (free base)
Chemical Formula: C22H23N3O3S
Exact Mass: 409.146
Molecular Weight: 409.504
Elemental Analysis: C, 64.53; H, 5.66; N, 10.26; O, 11.72; S, 7.83


Synonym: SAM531; SAM-531; SAM 531; PF-05212365; P -05212365; PF05212365; PF-5212365; P -5212365; PF5212365; WAY-262,531; WAY 262,531; WAY262,531; Cerlapirdine

IUPAC/Chemical Name: N,N-dimethyl-3-[(3-naphthalen-1-ylsulfonyl-2H-indazol-5-yl)oxy]propan-1-amine

InChi Key: NXQGEDVQXVTCDA-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H23N3O3S/c1-25(2)13-6-14-28-17-11-12-20-19(15-17)22(24-23-20)29(26,27)21-10-5-8-16-7-3-4-9-18(16)21/h3-5,7-12,15H,6,13-14H2,1-2H3,(H,23,24)

SMILES Code: O=S(C1=C2C=C(OCCCN(C)C)C=CC2=NN1)(C3=C4C=CC=CC4=CC=C3)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

Related:
925448-93-7 (Cerlapirdine free base)
925447-04-7 (Cerlapirdine HCl salt).


References

1: Tse S, Leung L, Raje S, Seymour M, Shishikura Y, Obach RS. Disposition and
metabolic profiling of [(14)C]cerlapirdine using accelerator mass spectrometry.
Drug Metab Dispos. 2014 Dec;42(12):2023-32. doi: 10.1124/dmd.114.059675. Epub
2014 Sep 12. PubMed PMID: 25217486.

2: Ly S, Pishdari B, Lok LL, Hajos M, Kocsis B. Activation of 5-HT6 receptors
modulates sleep-wake activity and hippocampal theta oscillation. ACS Chem
Neurosci. 2013 Jan 16;4(1):191-9. doi: 10.1021/cn300184t. Epub 2012 Dec 10.
PubMed PMID: 23336058; PubMed Central PMCID: PMC3547479.

3: Macauley D. American Chemical Society-239th national meeting--Investigating
new therapeutic candidates: part 1. 21-25 March 2010, San Francisco, CA, USA.
IDrugs. 2010 May;13(5):289-91. PubMed PMID: 20432180.