Danirixin
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MedKoo CAT#: 319712

CAS#: 954126-98-8

Description: Danirixin, also known as GSK1325756, is a potent, high-affinity, selective and reversible CXCR2 antagonist in development for treatment of chronic obstructive pulmonary disease. The dose-dependent inhibition of agonist-induced neutrophil activation following single and repeated once daily oral administration of danirixin suggests that this CXCR2 antagonist may have benefit in neutrophil-predominant inflammatory diseases.


Price and Availability

Size Price Shipping out time Quantity
50mg USD 550 2 Weeks
100mg USD 950 2 Weeks
200mg USD 1350 2 Weeks
500mg USD 2350 2 Weeks
1g USD 3450 2 Weeks
2g USD 5950 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-07-10. Prices are subject to change without notice.

Danirixin, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 319712
Name: Danirixin
CAS#: 954126-98-8
Chemical Formula: C19H21ClFN3O4S
Exact Mass: 441.0925
Molecular Weight: 441.9024
Elemental Analysis: C, 51.64; H, 4.79; Cl, 8.02; F, 4.30; N, 9.51; O, 14.48; S, 7.25


Synonym: GSK1325756; GSK-1325756; GSK 1325756; Danirixin

IUPAC/Chemical Name: (S)-1-(4-chloro-2-hydroxy-3-(piperidin-3-ylsulfonyl)phenyl)-3-(3-fluoro-2-methylphenyl)urea

InChi Key: NGYNBSHYFOFVLS-LBPRGKRZSA-N

InChi Code: InChI=1S/C19H21ClFN3O4S/c1-11-14(21)5-2-6-15(11)23-19(26)24-16-8-7-13(20)18(17(16)25)29(27,28)12-4-3-9-22-10-12/h2,5-8,12,22,25H,3-4,9-10H2,1H3,(H2,23,24,26)/t12-/m0/s1

SMILES Code: ClC(C(S([C@H]1CCCNC1)(=O)=O)=C2O)=CC=C2NC(NC3=CC=CC(F)=C3C)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (SDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Miller BE, Mistry S, Smart K, Connolly P, Carpenter DC, Cooray H, Bloomer JC,
Tal-Singer R, Lazaar AL. The pharmacokinetics and pharmacodynamics of danirixin
(GSK1325756)--a selective CXCR2 antagonist --in healthy adult subjects. BMC
Pharmacol Toxicol. 2015 Jun 20;16:18. doi: 10.1186/s40360-015-0017-x. PubMed
PMID: 26092545; PubMed Central PMCID: PMC4475328.

2: Miller BE, Smart K, Mistry S, Ambery CL, Bloomer JC, Connolly P, Sanderson D,
Shreeves T, Smith R, Lazaar AL. The pharmacokinetics of conventional and
bioenhanced tablet formulations of danirixin (GSK1325756) following oral
administration in healthy, elderly, human volunteers. Eur J Drug Metab
Pharmacokinet. 2014 Sep;39(3):173-81. doi: 10.1007/s13318-014-0179-8. Epub 2014
Feb 7. PubMed PMID: 24504700; PubMed Central PMCID: PMC4142138.

3: Bloomer JC, Nash M, Webb A, Miller BE, Lazaar AL, Beaumont C, Guiney WJ.
Assessment of potential drug interactions by characterization of human drug
metabolism pathways using non-invasive bile sampling. Br J Clin Pharmacol. 2013
Feb;75(2):488-96. doi: 10.1111/j.1365-2125.2012.04352.x. PubMed PMID: 22670830;
PubMed Central PMCID: PMC3579263.