WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 319688
Description: Vilaprisan, also known as BAY1002670 or BAY10-02670, is a potent and selective oral progesterone receptor modulator that holds the promises of long-term treatment of patients with symptomatic uterine fibroids. BAY1002670 in subnanomolar concentrations exhibits a highly selective binding profile and antagonistic activity for the PR. These properties are also reflected in its action in two progesterone-dependent animal models that assess the termination of pregnancy and endometrial transformation. In a human fibroid xenograft model BAY 1002670 showed a marked dose-dependent reduction of fibroid tumour weight gain of 95% at a dose of 3 mg/kg/day (P < 0.005).
MedKoo Cat#: 319688
Chemical Formula: C27H29F5O4S
Exact Mass: 544.1707
Molecular Weight: 544.577
Elemental Analysis: C, 59.55; H, 5.37; F, 17.44; O, 11.75; S, 5.89
Synonym: BAY1002670; BAY-1002670; BAY 1002670; BAY-10-02670; BAY10-02670; BAY 10-02670; Vilaprisan
IUPAC/Chemical Name: (8S,11R,13S,14S,17R)-17-hydroxy-13-methyl-11-(4-(methylsulfonyl)phenyl)-17-(perfluoroethyl)-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
InChi Key: JUFWQQVHQFDUOD-LJDQNPOQSA-N
InChi Code: InChI=1S/C27H29F5O4S/c1-24-14-21(15-3-7-18(8-4-15)37(2,35)36)23-19-10-6-17(33)13-16(19)5-9-20(23)22(24)11-12-25(24,34)26(28,29)27(30,31)32/h3-4,7-8,13,20-22,34H,5-6,9-12,14H2,1-2H3/t20-,21+,22-,24-,25+/m0/s1
SMILES Code: C[C@@]12[C@](C(F)(F)C(F)(F)F)(O)CC[C@@]1([H])[C@]3([H])CCC4=CC(CCC4=C3[C@@H](C5=CC=C(S(=O)(C)=O)C=C5)C2)=O
1: Wagenfeld A, Bone W, Schwede W, Fritsch M, Fischer OM, Moeller C. BAY 1002670:
a novel, highly potent and selective progesterone receptor modulator for
gynaecological therapies. Hum Reprod. 2013 Aug;28(8):2253-64. doi:
10.1093/humrep/det247. Epub 2013 Jun 5. PubMed PMID: 23739217.