Acorafloxacin free base
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 319666

CAS#: 878592-87-1 (free base)

Description: Acorafloxacin, also known as Avarofloxacin, JNJ-Q2 and JNJ-32729463, is a broad-spectrum fluoroquinolone antibacterial drug being developed for the treatment of acute bacterial skin and skin-structure infections and community-acquired pneumonia. Specifically, JNJ-Q2 is being actively studied for treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections.


Chemical Structure

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Acorafloxacin free base
CAS# 878592-87-1 (free base)

Theoretical Analysis

MedKoo Cat#: 319666
Name: Acorafloxacin free base
CAS#: 878592-87-1 (free base)
Chemical Formula: C21H23F2N3O4
Exact Mass: 419.1657
Molecular Weight: 419.4288
Elemental Analysis: C, 60.14; H, 5.53; F, 9.06; N, 10.02; O, 15.26

Price and Availability

Size Price Availability Quantity
1.0mg USD 85.0 2 Weeks
5.0mg USD 350.0 2 Weeks
10.0mg USD 550.0 2 Weeks
25.0mg USD 1150.0 2 Weeks
50.0mg USD 1950.0 2 Weeks
100.0mg USD 2950.0 2 Weeks
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Related CAS #: 878592-87-1 (free base)   1001162-01-1 (HCl)   1160946-14-4 (TFA)    

Synonym: JNJ-32729463; JNJ 32729463; JNJ32729463; JNJ-32729463-AAA; JNJ32729463-AAA; JNJ 32729463-AAA; JNJ-Q2; Acorafloxacin; Avarofloxacin

IUPAC/Chemical Name: (E)-7-(3-(2-amino-1-fluoroethylidene)piperidin-1-yl)-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

InChi Key: VMKVDAAFMQKZJS-LFIBNONCSA-N

InChi Code: InChI=1S/C21H23F2N3O4/c1-30-20-17-13(19(27)14(21(28)29)10-26(17)12-4-5-12)7-15(22)18(20)25-6-2-3-11(9-25)16(23)8-24/h7,10,12H,2-6,8-9,24H2,1H3,(H,28,29)/b16-11+

SMILES Code: O=C(C1=CN(C2CC2)C3=C(C=C(F)C(N4C/C(CCC4)=C(F)\CN)=C3OC)C1=O)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 419.4288 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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