Emeramide
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 319633

CAS#: 351994-94-0

Description: Emeramide, also known as NBMI or N,N'-Bis(2-mercaptoethyl)isophthalamide, is a mercury/heavy metal chelator. Emeramide molecule consists of two thiol groups and linked via a pair of amide groups. NBMI can be used to chelate heavy metals like lead, cadmium, copper, manganese, zinc, iron, and mercury from ground water, coal tailings, gold ore, waste water of battery-recycling plants, and contaminated soil.


Price and Availability

Size
Price

5g
USD 150
Size
Price

10g
USD 250
Size
Price

20g
USD 450

Emeramide, purity > 98%, is in stock. The same day shipping out after order is received. Shipping fee: from $30.00 (USA); from $45.00 (Canada), or from $70.00 (International). Delivery time: overnight (USA/Canada); 3-5 days (international, depending on customs clearance). NOTE: Emeramide we are supplying is intended for research and development use only, is not intended for use in humans or animals. This means that our product must not – under any circumstance – be purchased for human, drug, food, cosmetic, agricultural or domestic use. It should only be used by trained scientists working under controlled conditions who are familiar with the potential hazards. Moreover, for safety and regulation compliance, we only accept order from business, and we do not ship product to residential address. CUSTOMERS MUST SIGN THE LIMITED USE AGREEMENT BEFORE ORDERING EMERAMIDE. Please email to cchen@medkoo.com to request the "limited use agreement for emeramide".


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 319633
Name: Emeramide
CAS#: 351994-94-0
Chemical Formula: C12H16N2O2S2
Exact Mass: 284.0653
Molecular Weight: 284.39
Elemental Analysis: C, 50.68; H, 5.67; N, 9.85; O, 11.25; S, 22.55


Synonym: BDTH2; OSR; BDET; BDETH2; NBMI; Emeramide; N,N'-Bis(2-mercaptoethyl)isophthalamide

IUPAC/Chemical Name: N1,N3-bis(2-sulfanylethyl)benzene-1,3-dicarboxamide

InChi Key: JUTBAVRYDAKVGQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H16N2O2S2/c15-11(13-4-6-17)9-2-1-3-10(8-9)12(16)14-5-7-18/h1-3,8,17-18H,4-7H2,(H,13,15)(H,14,16)

SMILES Code: O=C(C1=CC=CC(C(NCCS)=O)=C1)NCCS


Technical Data

Appearance:
White to off-white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
2 years after customer received if the product is stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.03.00


Additional Information

Note: Emeramide has not been approved by FDA for human use as of July 2018. This chemical supplied by us, is not pharmaceutical grade, is intended for research use only, is not for human, animal and therapeutic use.


References

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2: Anuradha R, Munisankar S, Bhootra Y, Kumar NP, Dolla C, Babu S. Malnutrition is associated with diminished baseline and mycobacterial antigen - stimulated chemokine responses in latent tuberculosis infection. J Infect. 2018 May 17. pii: S0163-4453(18)30143-9. doi: 10.1016/j.jinf.2018.05.003. [Epub ahead of print] PubMed PMID: 29777718.

3: Schutzmeier P, Focil Baquerizo A, Castillo-Tandazo W, Focil N, Bose-O'Reilly S. Efficacy of N,N'bis-(2-mercaptoethyl) isophthalamide on mercury intoxication: a randomized controlled trial. Environ Health. 2018 Feb 14;17(1):15. doi: 10.1186/s12940-018-0358-1. PubMed PMID: 29444690; PubMed Central PMCID: PMC5813329.

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9: Uygun M, Şenay RH, Avcıbaşı N, Akgöl S. Poly(HEMA-co-NBMI) monolithic cryogel columns for IgG adsorption. Appl Biochem Biotechnol. 2014 Feb;172(3):1574-84. doi: 10.1007/s12010-013-0624-1. Epub 2013 Nov 14. PubMed PMID: 24233543.

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11: Allegra E, Puzzo L, Zuccalà V, Trapasso S, Vasquez E, Garozzo A, Caltabiano R. Nuclear BMI-1 expression in laryngeal carcinoma correlates with lymph node pathological status. World J Surg Oncol. 2012 Oct 2;10:206. doi: 10.1186/1477-7819-10-206. PubMed PMID: 23031716; PubMed Central PMCID: PMC3500717.

12: Clarke D, Buchanan R, Gupta N, Haley B. Amelioration of Acute Mercury Toxicity by a Novel, Non-Toxic Lipid Soluble Chelator N,N'bis-(2-mercaptoethyl)isophthalamide: Effect on Animal Survival, Health, Mercury Excretion and Organ Accumulation. Toxicol Environ Chem. 2012;94(3):616-640. PubMed PMID: 22573916; PubMed Central PMCID: PMC3346673.

13: Patel RB, Kotha SR, Sauers LA, Malireddy S, Gurney TO, Gupta NN, Elton TS, Magalang UJ, Marsh CB, Haley BE, Parinandi NL. Thiol-redox antioxidants protect against lung vascular endothelial cytoskeletal alterations caused by pulmonary fibrosis inducer, bleomycin: comparison between classical thiol-protectant, N-acetyl-L-cysteine, and novel thiol antioxidant, N,N'-bis-2-mercaptoethyl isophthalamide. Toxicol Mech Methods. 2012 Jun;22(5):383-96. doi: 10.3109/15376516.2012.673089. PubMed PMID: 22409285; PubMed Central PMCID: PMC3914546.

14: Secor JD, Kotha SR, Gurney TO, Patel RB, Kefauver NR, Gupta N, Morris AJ, Haley BE, Parinandi NL. Novel lipid-soluble thiol-redox antioxidant and heavy metal chelator, N,N'-bis(2-mercaptoethyl)isophthalamide (NBMI) and phospholipase D-specific inhibitor, 5-fluoro-2-indolyl des-chlorohalopemide (FIPI) attenuate mercury-induced lipid signaling leading to protection against cytotoxicity in aortic endothelial cells. Int J Toxicol. 2011 Dec;30(6):619-38. doi: 10.1177/1091581811422413. Epub 2011 Oct 12. PubMed PMID: 21994240; PubMed Central PMCID: PMC3503146.

15: Gupta R, Knobel D, Gunabushanam V, Agaba E, Ritter G, Marini C, Barrera R. The effect of low body mass index on outcome in critically ill surgical patients. Nutr Clin Pract. 2011 Oct;26(5):593-7. doi: 10.1177/0884533611419666. PubMed PMID: 21947642.

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