Emeramide
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 319633

CAS#: 351994-94-0

Description: Emeramide, also known as NBMI, BDTH2 or N,N'-Bis(2-mercaptoethyl)isophthalamide, is a mercury/heavy metal chelator. Emeramide molecule consists of two thiol groups and linked via a pair of amide groups. NBMI can be used to chelate heavy metals like lead, cadmium, copper, manganese, zinc, iron, and mercury from ground water, coal tailings, gold ore, waste water of battery-recycling plants, and contaminated soil.


Price and Availability

Size Price Shipping out time Quantity
5g USD 150 Same Day
10g USD 250 Same Day
20g USD 450 Same Day
Inquire bulk and customized quantity

Pricing updated 2020-02-27. Prices are subject to change without notice.

Emeramide, purity > 99%, is in stock. The same day shipping out after order is received. Customers may order online through below web page: https://hodoodo.com/products/4353/emeramide


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 319633
Name: Emeramide
CAS#: 351994-94-0
Chemical Formula: C12H16N2O2S2
Exact Mass: 284.0653
Molecular Weight: 284.39
Elemental Analysis: C, 50.68; H, 5.67; N, 9.85; O, 11.25; S, 22.55


Synonym: BDTH2; BDET; BDETH2; NBMI; Emeramide; N,N'-Bis(2-mercaptoethyl)isophthalamide; trade names B9, MetX, OSR and OSR#1.

IUPAC/Chemical Name: N1,N3-bis(2-sulfanylethyl)benzene-1,3-dicarboxamide

InChi Key: JUTBAVRYDAKVGQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H16N2O2S2/c15-11(13-4-6-17)9-2-1-3-10(8-9)12(16)14-5-7-18/h1-3,8,17-18H,4-7H2,(H,13,15)(H,14,16)

SMILES Code: O=C(C1=CC=CC(C(NCCS)=O)=C1)NCCS


Technical Data

Appearance:
White to off-white solid powder with density 0.64 g/mL

Purity:
>99% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (SDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
2 years after customer received if the product is stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


Additional Information

Note:
1. Emeramide, being developed by EmeraMed, is currently under clinical trials. Emeramide has not been approved by FDA for human use as of Jan 2020.
2. Emeramide we are supplying is guaranteed to have excellent quality. However, it is not pharmaceutical grade ( i.e. not made under GMP guideline). Our emeramide is intended for research and development use only, is not intended for use in humans or animals. This means that our product must not – under any circumstance – be purchased for human, drug, food, cosmetic, agricultural or domestic use. It should only be used by trained scientists working under controlled conditions who are familiar with the potential hazards. Moreover, for safety and regulation compliance, we only accept order from business, and we do not ship product to residential address. CUSTOMERS MUST SIGN THE LIMITED USE AGREEMENT BEFORE ORDERING EMERAMIDE. Please email to cchen@medkoo.com to request the "limited use agreement for emeramide".
3. Customer, who does not know how to use this product, should not order it from us since we will not provide "how-to-use instruction".


References

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2: Anuradha R, Munisankar S, Bhootra Y, Kumar NP, Dolla C, Babu S. Malnutrition is associated with diminished baseline and mycobacterial antigen - stimulated chemokine responses in latent tuberculosis infection. J Infect. 2018 May 17. pii: S0163-4453(18)30143-9. doi: 10.1016/j.jinf.2018.05.003. [Epub ahead of print] PubMed PMID: 29777718.

3: Schutzmeier P, Focil Baquerizo A, Castillo-Tandazo W, Focil N, Bose-O'Reilly S. Efficacy of N,N'bis-(2-mercaptoethyl) isophthalamide on mercury intoxication: a randomized controlled trial. Environ Health. 2018 Feb 14;17(1):15. doi: 10.1186/s12940-018-0358-1. PubMed PMID: 29444690; PubMed Central PMCID: PMC5813329.

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9: Uygun M, Şenay RH, Avcıbaşı N, Akgöl S. Poly(HEMA-co-NBMI) monolithic cryogel columns for IgG adsorption. Appl Biochem Biotechnol. 2014 Feb;172(3):1574-84. doi: 10.1007/s12010-013-0624-1. Epub 2013 Nov 14. PubMed PMID: 24233543.

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12: Clarke D, Buchanan R, Gupta N, Haley B. Amelioration of Acute Mercury Toxicity by a Novel, Non-Toxic Lipid Soluble Chelator N,N'bis-(2-mercaptoethyl)isophthalamide: Effect on Animal Survival, Health, Mercury Excretion and Organ Accumulation. Toxicol Environ Chem. 2012;94(3):616-640. PubMed PMID: 22573916; PubMed Central PMCID: PMC3346673.

13: Patel RB, Kotha SR, Sauers LA, Malireddy S, Gurney TO, Gupta NN, Elton TS, Magalang UJ, Marsh CB, Haley BE, Parinandi NL. Thiol-redox antioxidants protect against lung vascular endothelial cytoskeletal alterations caused by pulmonary fibrosis inducer, bleomycin: comparison between classical thiol-protectant, N-acetyl-L-cysteine, and novel thiol antioxidant, N,N'-bis-2-mercaptoethyl isophthalamide. Toxicol Mech Methods. 2012 Jun;22(5):383-96. doi: 10.3109/15376516.2012.673089. PubMed PMID: 22409285; PubMed Central PMCID: PMC3914546.

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