GDC-0326
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 206579

CAS#: 1282514-88-8

Description: GDC-0326 is a potent and selective inhibitor of α-Isoform of Phosphoinositide 3-Kinase (PI3Kalpha inhibitor). GDC-0326 achieves a very high level of selectivity over other kinases. GDC-0326 has low plasma CL in human. Within the PI3 kinase family, there are four class I PI3K isoforms (α, β, δ, and γ). Of these isoforms, PI3Kα is the most commonly associated with cancers.


Price and Availability

Size
Price

10mg
USD 250
100mg
USD 1250
1g
USD 3850
Size
Price

25mg
USD 450
200mg
USD 1750
2g
USD 5650
Size
Price

50mg
USD 750
500mg
USD 2450
5g
USD 9850

GDC-0326, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 206579
Name: GDC-0326
CAS#: 1282514-88-8
Chemical Formula: C19H22N6O3
Exact Mass: 382.1753
Molecular Weight: 382.424
Elemental Analysis: C, 59.67; H, 5.80; N, 21.98; O, 12.55


Synonym: GDC-0326; GDC 0326; GDC0326; CAS#1282514-88-8

IUPAC/Chemical Name: (S)-2-((2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide

InChi Key: SIKYDKLGPWRPMZ-LBPRGKRZSA-N

InChi Code: InChI=1S/C19H22N6O3/c1-11(2)25-19(21-10-22-25)15-9-24-6-7-27-16-8-13(28-12(3)17(20)26)4-5-14(16)18(24)23-15/h4-5,8-12H,6-7H2,1-3H3,(H2,20,26)/t12-/m0/s1

SMILES Code: C[C@H](OC1=CC=C2C3=NC(C4=NC=NN4C(C)C)=CN3CCOC2=C1)C(N)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Heffron TP, Heald RA, Ndubaku C, Wei B, Augistin M, Do S, Edgar K, Eigenbrot
C, Friedman L, Gancia E, Jackson PS, Jones G, Kolesnikov A, Lee LB, Lesnick JD,
Lewis C, McLean N, Mörtl M, Nonomiya J, Pang J, Price S, Prior WW, Salphati L,
Sideris S, Staben ST, Steinbacher S, Tsui V, Wallin J, Sampath D, Olivero AG. The
Rational Design of Selective Benzoxazepin Inhibitors of the α-Isoform of
Phosphoinositide 3-Kinase Culminating in the Identification of
(S)-2-((2-(1-Isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1
,4]oxazepin-9-yl)oxy)propanamide (GDC-0326). J Med Chem. 2016 Jan 20. [Epub ahead
of print] PubMed PMID: 26741947.