KL001
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MedKoo CAT#: 522570

CAS#: 309928-48-1

Description: KL001 is a Cryptochrome protein (CRY) stabilizer. KL001 prevented ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. In combination with mathematical modeling, our studies using KL001 revealed that CRY1 and CRY2 share a similar functional role in the period regulation. Furthermore, KL001-mediated CRY stabilization inhibited glucagon-induced gluconeogenesis in primary hepatocytes. KL001 thus provides a tool to study the regulation of CRY-dependent physiology and aid development of clock-based therapeutics of diabetes.


Chemical Structure

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KL001
CAS# 309928-48-1

Theoretical Analysis

MedKoo Cat#: 522570
Name: KL001
CAS#: 309928-48-1
Chemical Formula: C21H22N2O4S
Exact Mass: 398.13
Molecular Weight: 398.477
Elemental Analysis: C, 63.30; H, 5.57; N, 7.03; O, 16.06; S, 8.05

Price and Availability

Size Price Availability Quantity
50.0mg USD 450.0 2 Weeks
100.0mg USD 750.0 2 Weeks
200.0mg USD 1250.0 2 Weeks
500.0mg USD 2850.0 2 Weeks
1.0g USD 3850.0 2 Weeks
2.0g USD 6250.0 2 Weeks
Bulk inquiry

Synonym: KL001; KL-001; KL 001.

IUPAC/Chemical Name: N-[3-(9H-Carbazol-9-yl)-2-hydroxypropyl]-N-(2-furanylmethyl)methanesulfonamide

InChi Key: OQAFDLPAPSSOHY-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H22N2O4S/c1-28(25,26)22(15-17-7-6-12-27-17)13-16(24)14-23-20-10-4-2-8-18(20)19-9-3-5-11-21(19)23/h2-12,16,24H,13-15H2,1H3

SMILES Code: CS(=O)(N(CC(O)CN1C2=C(C3=C1C=CC=C3)C=CC=C2)CC4=CC=CO4)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 398.477 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Lee JW, Hirota T, Kumar A, Kim NJ, Irle S, Kay SA. Development of
Small-Molecule Cryptochrome Stabilizer Derivatives as Modulators of the Circadian
Clock. ChemMedChem. 2015 Sep;10(9):1489-97. doi: 10.1002/cmdc.201500260. Epub
2015 Jul 14. PubMed PMID: 26174033; PubMed Central PMCID: PMC4576822.

2: Oshima T, Yamanaka I, Kumar A, Yamaguchi J, Nishiwaki-Ohkawa T, Muto K,
Kawamura R, Hirota T, Yagita K, Irle S, Kay SA, Yoshimura T, Itami K. C-H
activation generates period-shortening molecules that target cryptochrome in the
mammalian circadian clock. Angew Chem Int Ed Engl. 2015 Jun 8;54(24):7193-7. doi:
10.1002/anie.201502942. Epub 2015 May 8. PubMed PMID: 25960183.

3: St John PC, Hirota T, Kay SA, Doyle FJ 3rd. Spatiotemporal separation of PER
and CRY posttranslational regulation in the mammalian circadian clock. Proc Natl
Acad Sci U S A. 2014 Feb 4;111(5):2040-5. doi: 10.1073/pnas.1323618111. Epub 2014
Jan 21. PubMed PMID: 24449901; PubMed Central PMCID: PMC3918757.

4: Kelleher FC, Rao A, Maguire A. Circadian molecular clocks and cancer. Cancer
Lett. 2014 Jan 1;342(1):9-18. doi: 10.1016/j.canlet.2013.09.040. Epub 2013 Oct 4.
Review. PubMed PMID: 24099911.

5: Nangle S, Xing W, Zheng N. Crystal structure of mammalian cryptochrome in
complex with a small molecule competitor of its ubiquitin ligase. Cell Res. 2013
Dec;23(12):1417-9. doi: 10.1038/cr.2013.136. Epub 2013 Oct 1. PubMed PMID:
24080726; PubMed Central PMCID: PMC3847572.

6: Sklan A. Discovery of activator for cryptochrome may shape development of
metabolic drugs. Future Med Chem. 2012 Sep;4(13):1660. PubMed PMID: 23087927.

7: Hirota T, Lee JW, St John PC, Sawa M, Iwaisako K, Noguchi T, Pongsawakul PY,
Sonntag T, Welsh DK, Brenner DA, Doyle FJ 3rd, Schultz PG, Kay SA. Identification
of small molecule activators of cryptochrome. Science. 2012 Aug
31;337(6098):1094-7. doi: 10.1126/science.1223710. Epub 2012 Jul 12. PubMed PMID:
22798407; PubMed Central PMCID: PMC3589997.

KL001

50.0mg / USD 450.0