Verdiperstat

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 319590

CAS#: 890655-80-8

Description: Verdiperstat, also known as AZD-3241, is a selective and irreversible inhibitor of myeloperoxidase currently being developed to delay progression in patients with neurodegenerative brain disorders.

Chemical Structure

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Verdiperstat
CAS# 890655-80-8
Instruction

Theoretical Analysis

MedKoo Cat#: 319590
Name: Verdiperstat
CAS#: 890655-80-8
Chemical Formula: C11H15N3O2S
Exact Mass: 253.09
Molecular Weight: 253.320
Elemental Analysis: C, 52.16; H, 5.97; N, 16.59; O, 12.63; S, 12.66

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: AZD-3241; AZD 3241; AZD3241; Verdiperstat; CAS#890655-80-8.

IUPAC/Chemical Name: 1-[2-(propan-2-yloxy)ethyl]-2-sulfanylidene-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-one

InChi Key: FVJCUZCRPIMVLB-UHFFFAOYSA-N

InChi Code: InChI=1S/C11H15N3O2S/c1-7(2)16-6-5-14-8-3-4-12-9(8)10(15)13-11(14)17/h3-4,7,12H,5-6H2,1-2H3,(H,13,15,17)

SMILES Code: O=C(N1)C(NC=C2)=C2N(CCOC(C)C)C1=S

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 253.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Kaindlstorfer C, Sommer P, Georgievska B, Mather RJ, Kugler AR, Poewe W, Wenning GK, Stefanova N. Failure of Neuroprotection Despite Microglial Suppression by Delayed-Start Myeloperoxidase Inhibition in a Model of Advanced Multiple System Atrophy: Clinical Implications. Neurotox Res. 2015 Oct;28(3):185-94. doi: 10.1007/s12640-015-9547-7. Epub 2015 Jul 21. PubMed PMID: 26194617; PubMed Central PMCID: PMC4556742.

2: Jucaite A, Svenningsson P, Rinne JO, Cselényi Z, Varnäs K, Johnström P, Amini N, Kirjavainen A, Helin S, Minkwitz M, Kugler AR, Posener JA, Budd S, Halldin C, Varrone A, Farde L. Effect of the myeloperoxidase inhibitor AZD3241 on microglia: a PET study in Parkinson's disease. Brain. 2015 Sep;138(Pt 9):2687-700. doi: 10.1093/brain/awv184. Epub 2015 Jul 1. PubMed PMID: 26137956.

3: Johnström P, Bergman L, Varnäs K, Malmquist J, Halldin C, Farde L. Development of rapid multistep carbon-11 radiosynthesis of the myeloperoxidase inhibitor AZD3241 to assess brain exposure by PET microdosing. Nucl Med Biol. 2015 Jun;42(6):555-60. doi: 10.1016/j.nucmedbio.2015.02.001. Epub 2015 Feb 8. PubMed PMID: 25726760.