WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 319579
CAS#: 519187-97-4 (maleate)
Description: Edonerpic, also known as T-817, is a neuroprotectant. Edonerpic is a candidate therapeutic agent for Alzheimer's disease that inhibits oxidative stress and nitric oxide-induced neurotoxicity and acts as a neurotrophic factor. Edonerpic protects against MPTP-induced neurotoxicity by blocking lipid peroxidation in the SNc, and imply that this compound may be useful for treating neurodegenerative disorders related to oxidative stress, such as Parkinson's disease.
MedKoo Cat#: 319579
Name: Edonerpic maleate
CAS#: 519187-97-4 (maleate)
Chemical Formula: C20H25NO6S
Exact Mass: 291.1293
Molecular Weight: 407.481
Elemental Analysis: C, 58.95; H, 6.18; N, 3.44; O, 23.56; S, 7.87
Related CAS #: 519187-23-6 (free base) 519187-97-4 (maleate)
Synonym: T-817 maleate; T-817; T 817; T817; J2.179.155E; T-817MA; Edonerpic; Edonerpic maleate
IUPAC/Chemical Name: 1-(3-(2-(benzo[b]thiophen-5-yl)ethoxy)propyl)azetidin-3-ol maleate
InChi Key: RLUCYBFCLXANSO-BTJKTKAUSA-N
InChi Code: InChI=1S/C16H21NO2S.C4H4O4/c18-15-11-17(12-15)6-1-7-19-8-4-13-2-3-16-14(10-13)5-9-20-16;5-3(6)1-2-4(7)8/h2-3,5,9-10,15,18H,1,4,6-8,11-12H2;1-2H,(H,5,6)(H,7,8)/b;2-1-
SMILES Code: OC1CN(CCCOCCC2=CC=C3C(C=CS3)=C2)C1.O=C(O)/C=C\C(O)=O
Related CAS#
CAS#519187-23-6 (t Edonerpic free base);
CAS#519187-97-4 (t Edonerpic maleate).
1: Page SJ, Murray C, Hermann V, Levine P. Retention of motor changes in chronic
stroke survivors who were administered mental practice. Arch Phys Med Rehabil.
2011 Nov;92(11):1741-5. doi: 10.1016/j.apmr.2011.06.009. Epub 2011 Aug 31. PubMed
PMID: 21880300; PubMed Central PMCID: PMC3257856.
2: Moreno H, Choi S, Yu E, Brusco J, Avila J, Moreira JE, Sugimori M, Llinás RR.
Blocking Effects of Human Tau on Squid Giant Synapse Transmission and Its
Prevention by T-817 MA. Front Synaptic Neurosci. 2011 May 17;3:3. doi:
10.3389/fnsyn.2011.00003. eCollection 2011. PubMed PMID: 21629767; PubMed Central
PMCID: PMC3099362.
3: Kawasaki T, Ago Y, Kitao T, Nashida T, Takagi A, Takuma K, Matsuda T. A
neuroprotective agent, T-817MA (1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}
azetidin-3-ol maleate), prevents
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in mice.
Neuropharmacology. 2008 Oct;55(5):654-60. doi: 10.1016/j.neuropharm.2008.05.032.
Epub 2008 Jun 5. PubMed PMID: 18573265.