Edonerpic maleate
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 319579

CAS#: 519187-97-4 (maleate)

Description: Edonerpic, also known as T-817, is a neuroprotectant. Edonerpic is a candidate therapeutic agent for Alzheimer's disease that inhibits oxidative stress and nitric oxide-induced neurotoxicity and acts as a neurotrophic factor. Edonerpic protects against MPTP-induced neurotoxicity by blocking lipid peroxidation in the SNc, and imply that this compound may be useful for treating neurodegenerative disorders related to oxidative stress, such as Parkinson's disease.


Price and Availability

Size
Price

25mg
USD 150
200mg
USD 750
2g
USD 4250
Size
Price

50mg
USD 250
500mg
USD 1650
5g
USD 6950
Size
Price

100mg
USD 450
1g
USD 2950

Edonerpic maleate, purity > 98%, is in stock. The same day shipping out after order is received. Note: the estimated shipping out time for order > 4g may be 2 weeks.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 319579
Name: Edonerpic maleate
CAS#: 519187-97-4 (maleate)
Chemical Formula: C20H25NO6S
Exact Mass: 291.1293
Molecular Weight: 407.481
Elemental Analysis: C, 58.95; H, 6.18; N, 3.44; O, 23.56; S, 7.87


Related CAS #: 519187-23-6 (free base)   519187-97-4 (maleate)    

Synonym: T-817 maleate; T-817; T 817; T817; J2.179.155E; T-817MA; Edonerpic; Edonerpic maleate

IUPAC/Chemical Name: 1-(3-(2-(benzo[b]thiophen-5-yl)ethoxy)propyl)azetidin-3-ol maleate

InChi Key: RLUCYBFCLXANSO-BTJKTKAUSA-N

InChi Code: InChI=1S/C16H21NO2S.C4H4O4/c18-15-11-17(12-15)6-1-7-19-8-4-13-2-3-16-14(10-13)5-9-20-16;5-3(6)1-2-4(7)8/h2-3,5,9-10,15,18H,1,4,6-8,11-12H2;1-2H,(H,5,6)(H,7,8)/b;2-1-

SMILES Code: OC1CN(CCCOCCC2=CC=C3C(C=CS3)=C2)C1.O=C(O)/C=C\C(O)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934990300


Additional Information

Related CAS#
CAS#519187-23-6 (t Edonerpic free base);
CAS#519187-97-4 (t Edonerpic maleate).


References

1: Page SJ, Murray C, Hermann V, Levine P. Retention of motor changes in chronic
stroke survivors who were administered mental practice. Arch Phys Med Rehabil.
2011 Nov;92(11):1741-5. doi: 10.1016/j.apmr.2011.06.009. Epub 2011 Aug 31. PubMed
PMID: 21880300; PubMed Central PMCID: PMC3257856.

2: Moreno H, Choi S, Yu E, Brusco J, Avila J, Moreira JE, Sugimori M, Llinás RR.
Blocking Effects of Human Tau on Squid Giant Synapse Transmission and Its
Prevention by T-817 MA. Front Synaptic Neurosci. 2011 May 17;3:3. doi:
10.3389/fnsyn.2011.00003. eCollection 2011. PubMed PMID: 21629767; PubMed Central
PMCID: PMC3099362.

3: Kawasaki T, Ago Y, Kitao T, Nashida T, Takagi A, Takuma K, Matsuda T. A
neuroprotective agent, T-817MA (1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}
azetidin-3-ol maleate), prevents
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in mice.
Neuropharmacology. 2008 Oct;55(5):654-60. doi: 10.1016/j.neuropharm.2008.05.032.
Epub 2008 Jun 5. PubMed PMID: 18573265.