Verosudil
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MedKoo CAT#: 319562

CAS#: 1414854-42-4 (free base)

Description: Verosudil, also known as AR-12286, is a potent and selective Rho kinase inhibitor. AR-12286 was well tolerated and provided statistically significant reduction in IOP (intraocular pressure) in patients with XFS (exfoliation syndrome) and OHT (ocular hypertension) or XFG (exfoliative glaucoma). This drug may represent an additional therapeutic paradigm for the treatment of XFG.


Price and Availability

Size Price Shipping out time Quantity
5mg USD 90 Same day
10mg USD 150 Same day
25mg USD 250 Same day
50mg USD 450 Same day
100mg USD 650 Same day
200mg USD 950 Same day
500mg USD 1850 Same day
1g USD 2950 Same day
2g USD 5250 Same day
Inquire bulk and customized quantity

Pricing updated 2020-09-27. Prices are subject to change without notice.

Verosudil free base, purity > 98%, is in stock. The same day shipping out after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 319562
Name: Verosudil
CAS#: 1414854-42-4 (free base)
Chemical Formula: C17H17N3O2S
Exact Mass: 327.1041
Molecular Weight: 327.4
Elemental Analysis: C, 62.37; H, 5.23; N, 12.83; O, 9.77; S, 9.79


Related CAS #: 1414854-42-4 (free base)   1414854-44-6 (HCl)    

Synonym: AR-12286; AR12286; AR 12286; Verosudil; Verosudil free base.

IUPAC/Chemical Name: 2-(dimethylamino)-N-(1-oxo- 1,2-dihydroisoquinolin-6-yl)-2-(thiophen-3-yl)acetamide

InChi Key: VDYRZXYYQMMFJW-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H17N3O2S/c1-20(2)15(12-6-8-23-10-12)17(22)19-13-3-4-14-11(9-13)5-7-18-16(14)21/h3-10,15H,1-2H3,(H,18,21)(H,19,22)

SMILES Code: O=C(NC1=CC2=C(C(NC=C2)=O)C=C1)C(N(C)C)C3=CSC=C3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (SDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Skaat A, Jasien JV, Ritch R. Efficacy of Topically Administered Rho-Kinase Inhibitor AR-12286 in Patients With Exfoliation Syndrome and Ocular Hypertension or Glaucoma. J Glaucoma. 2016 Sep;25(9):e807-14. doi: 10.1097/IJG.0000000000000508. PMID: 27552517.

2: Kopczynski C, Novack GD, Swearingen D, van Haarlem T. Ocular hypotensive efficacy, safety and systemic absorption of AR-12286 ophthalmic solution in normal volunteers. Br J Ophthalmol. 2013 May;97(5):567-72. doi: 10.1136/bjophthalmol-2012-302466. Epub 2013 Feb 22. PMID: 23435190.

3: Williams RD, Novack GD, van Haarlem T, Kopczynski C; AR-12286 Phase 2A Study Group. Ocular hypotensive effect of the Rho kinase inhibitor AR-12286 in patients with glaucoma and ocular hypertension. Am J Ophthalmol. 2011 Nov;152(5):834-41.e1. doi: 10.1016/j.ajo.2011.04.012. Epub 2011 Jul 27. PMID: 21794845.

4: Hookes L. Association for Research in Vision and Ophthalmology (ARVO)--2010 Annual Meeting. For Sight: The Future of Eye and Vision Research--part 2. IDrugs. 2010 Jul;13(7):430-2. PMID: 20582863.