Ibiglustat

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Description: Venglustat, also known as Ibiglustat, GZ402671, GZ-452; Genz-682452 and SAR402671, is a potent and selective Glucosylceramide synthase inhibitor and ceramide glucosyltransferase inhibitor. Ibiglustat blocks the formation of glucosylceramide (GL-1), a key intermediate in the synthesis of GL-3. Ibiglustat is potentially useful for treating Fabry disease. Fabry disease is a rare lysosomal storage disorder, which results in abnormal tissue deposits of a particular fatty substance called globotriaosylceramide (GL-3 or Gb3) throughout the body.

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Chemical Structure

Theoretical Analysis

MedKoo Cat#: 319547
Name: Ibiglustat
CAS#: 1401090-53-6 (free base)
Chemical Formula: C20H24FN3O2S
Exact Mass: 389.1573
Molecular Weight: 389.49
Elemental Analysis: C, 61.68; H, 6.21; F, 4.88; N, 10.79; O, 8.22; S, 8.23

Related CAS #: 1401090-53-6 (free base)   1629063-79-1 (HCl)   1629063-80-4 (succinic acid)   1629063-78-0 (malate)  

Synonym: GZ-402671; GZ402671; GZ 402671; SAR402671; SAR-402671; SAR 402671; Genz-682452-AA; Ibiglustat; GZ-452; Genz-682452; Venglustat;

IUPAC/Chemical Name: (3S)-1-azabicyclo[2.2.2]octan-3-yl N-{2-[2-(4-fluorophenyl)- 1,3-thiazol-4-yl]propan-2-yl}carbamate

InChi Key: YFHRCLAKZBDRHN-MRXNPFEDSA-N

InChi Code: InChI=1S/C20H24FN3O2S/c1-20(2,17-12-27-18(22-17)14-3-5-15(21)6-4-14)23-19(25)26-16-11-24-9-7-13(16)8-10-24/h3-6,12-13,16H,7-11H2,1-2H3,(H,23,25)/t16-/m1/s1

SMILES Code: O=C(O[C@@H]1CN2CCC1CC2)NC(C)(C3=CSC(C4=CC=C(F)C=C4)=N3)C

Technical Data

Additional Information

Related CAS#
1401090-53-6
1629063-78-0 (